A 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering

Small protein ligands can provide superior physiological distribution compared with antibodies, and improved stability, production, and specific conjugation. Systematic evaluation of the PDB identified a scaffold to push the limits of small size and robust evolution of stable, high-affinity ligands:...

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Veröffentlicht in:	Chemistry & biology 2015-07, Vol.22 (7), p.946-956
Hauptverfasser:	Kruziki, Max A., Bhatnagar, Sumit, Woldring, Daniel R., Duong, Vandon T., Hackel, Benjamin J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Amino Acids - metabolism Databases, Protein Humans Ligands Models, Molecular Mutation Protein Binding Protein Engineering - methods Protein Structure, Tertiary Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Substrate Specificity
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