Total Synthesis of 4,5-Didehydroguadiscine: A Potent Melanogenesis Inhibitor from the Brazilian Medicinal Herb, Hornschuchia obliqua

The first total synthesis of the 7,7-dimethylaporphinoid, 4,5-didehydroguadiscine (6), originally isolated from the stems and roots of Hornschuchia oblique (Annonaceae), was achieved by the condensation of homopiperonylamine (7) with an α,α-dimethylphenylacetic acid derivative (8) and subsequent Psc...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2015-07, Vol.78 (7), p.1536-1542
Hauptverfasser:	Tanabe, Genzoh, Sugano, Youta, Shirato, Miki, Sonoda, Naoki, Tsutsui, Nozomi, Morikawa, Toshio, Ninomiya, Kiyofumi, Yoshikawa, Masayuki, Muraoka, Osamu
Format:	Artikel
Sprache:	eng
Schlagworte:	Annonaceae - chemistry Aporphines - chemical synthesis Aporphines - chemistry Aporphines - pharmacology Arbutin - pharmacology Brazil Esters Melanins - antagonists & inhibitors Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots - chemistry Plants, Medicinal - chemistry
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