Anti-inflammatory Activity of Saxifragin via Inhibition of NF-κB Involves Caspase‑1 Activation

Saxifragin, the 5-glucoside of the flavonoid quercetin, is found in plants and insects. It has been reported that saxifragin has peroxynitrite-scavenging effects. However, the mechanism of anti-inflammatory effects of saxifragin has not yet been clearly identified. In this study, we investigated the...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2015-07, Vol.78 (7), p.1579-1585
Hauptverfasser:	Cheon, Se-Yun, Chung, Kyung-Sook, Jeon, Eunjin, Nugroho, Agung, Park, Hee-Jun, An, Hyo-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Caspase 1 - drug effects Caspase 1 - metabolism Cyclooxygenase 2 - metabolism Dinoprostone - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Flavonoids - chemistry Flavonoids - pharmacology I-kappa B Proteins - metabolism Inflammation - drug therapy Interleukin-6 - metabolism Lipopolysaccharides - pharmacology Macrophages - drug effects Mice Mitogen-Activated Protein Kinases - metabolism Molecular Structure NF-kappa B - antagonists & inhibitors Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - antagonists & inhibitors Signal Transduction - drug effects
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