By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer
Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediate...
Gespeichert in:
| Veröffentlicht in: | Oncotarget 2015-06, Vol.6 (18), p.16461-16470 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 16470 |
|---|---|
| container_issue | 18 |
| container_start_page | 16461 |
| container_title | Oncotarget |
| container_volume | 6 |
| creator | Zhang, Qing Song, Yanyan Chen, Wei Wang, Xiaohui Miao, Zhifeng Cao, Liu Li, Feng Wang, Guiling |
| description | Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1698961252</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1698961252</sourcerecordid><originalsourceid>FETCH-LOGICAL-p564-63d9cb3b4d11eb8c91057f9cde6f7ead9a3244efae30dcf076260d0ef3b733393</originalsourceid><addsrcrecordid>eNo1j09LwzAchoMgbsx9BcnRg8X8a9IcZ52bMBnIwGNJk19GpO1i0h727R0438t7eXh43xs0p1rogpUln6Flzt_kklKoiuk7NGOS6EopMUfrlzNOYNMUxjAc8fZ1VdMn_LH_rBnOU4wJcoaMI6P4y3j6XIdIcRjw0eQxBYutGSyke3TrTZdhee0FOrytD_W22O037_VqV8RSikJyp23LW-EohbaympJSeW0dSK_AOG04EwK8AU6c9UTJy05HwPNWcc41X6DHP21Mp58J8tj0IVvoOjPAacoNlbrSkrKSXdCHKzq1PbgmptCbdG7-n_Nfc9RSCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1698961252</pqid></control><display><type>article</type><title>By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free E- Journals</source><creator>Zhang, Qing ; Song, Yanyan ; Chen, Wei ; Wang, Xiaohui ; Miao, Zhifeng ; Cao, Liu ; Li, Feng ; Wang, Guiling</creator><creatorcontrib>Zhang, Qing ; Song, Yanyan ; Chen, Wei ; Wang, Xiaohui ; Miao, Zhifeng ; Cao, Liu ; Li, Feng ; Wang, Guiling</creatorcontrib><description>Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.</description><identifier>EISSN: 1949-2553</identifier><identifier>PMID: 26098774</identifier><language>eng</language><publisher>United States</publisher><subject>Cell Proliferation - genetics ; Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors ; Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis ; DNA-Binding Proteins - metabolism ; Down-Regulation ; Histone Deacetylase 1 - metabolism ; Humans ; Promoter Regions, Genetic - genetics ; RNA Interference ; RNA, Messenger - genetics ; RNA, Small Interfering ; Stomach Neoplasms - pathology ; Transcription Factors - genetics ; Transcription Factors - metabolism ; Transcription, Genetic - genetics ; Tumor Cells, Cultured ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Oncotarget, 2015-06, Vol.6 (18), p.16461-16470</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26098774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Song, Yanyan</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Wang, Xiaohui</creatorcontrib><creatorcontrib>Miao, Zhifeng</creatorcontrib><creatorcontrib>Cao, Liu</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><creatorcontrib>Wang, Guiling</creatorcontrib><title>By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.</description><subject>Cell Proliferation - genetics</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Down-Regulation</subject><subject>Histone Deacetylase 1 - metabolism</subject><subject>Humans</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>RNA Interference</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Small Interfering</subject><subject>Stomach Neoplasms - pathology</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic - genetics</subject><subject>Tumor Cells, Cultured</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j09LwzAchoMgbsx9BcnRg8X8a9IcZ52bMBnIwGNJk19GpO1i0h727R0438t7eXh43xs0p1rogpUln6Flzt_kklKoiuk7NGOS6EopMUfrlzNOYNMUxjAc8fZ1VdMn_LH_rBnOU4wJcoaMI6P4y3j6XIdIcRjw0eQxBYutGSyke3TrTZdhee0FOrytD_W22O037_VqV8RSikJyp23LW-EohbaympJSeW0dSK_AOG04EwK8AU6c9UTJy05HwPNWcc41X6DHP21Mp58J8tj0IVvoOjPAacoNlbrSkrKSXdCHKzq1PbgmptCbdG7-n_Nfc9RSCw</recordid><startdate>20150630</startdate><enddate>20150630</enddate><creator>Zhang, Qing</creator><creator>Song, Yanyan</creator><creator>Chen, Wei</creator><creator>Wang, Xiaohui</creator><creator>Miao, Zhifeng</creator><creator>Cao, Liu</creator><creator>Li, Feng</creator><creator>Wang, Guiling</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20150630</creationdate><title>By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer</title><author>Zhang, Qing ; Song, Yanyan ; Chen, Wei ; Wang, Xiaohui ; Miao, Zhifeng ; Cao, Liu ; Li, Feng ; Wang, Guiling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p564-63d9cb3b4d11eb8c91057f9cde6f7ead9a3244efae30dcf076260d0ef3b733393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Cell Proliferation - genetics</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Down-Regulation</topic><topic>Histone Deacetylase 1 - metabolism</topic><topic>Humans</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>RNA Interference</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Small Interfering</topic><topic>Stomach Neoplasms - pathology</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic - genetics</topic><topic>Tumor Cells, Cultured</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Qing</creatorcontrib><creatorcontrib>Song, Yanyan</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Wang, Xiaohui</creatorcontrib><creatorcontrib>Miao, Zhifeng</creatorcontrib><creatorcontrib>Cao, Liu</creatorcontrib><creatorcontrib>Li, Feng</creatorcontrib><creatorcontrib>Wang, Guiling</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Qing</au><au>Song, Yanyan</au><au>Chen, Wei</au><au>Wang, Xiaohui</au><au>Miao, Zhifeng</au><au>Cao, Liu</au><au>Li, Feng</au><au>Wang, Guiling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2015-06-30</date><risdate>2015</risdate><volume>6</volume><issue>18</issue><spage>16461</spage><epage>16470</epage><pages>16461-16470</pages><eissn>1949-2553</eissn><abstract>Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.</abstract><cop>United States</cop><pmid>26098774</pmid><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1949-2553 |
| ispartof | Oncotarget, 2015-06, Vol.6 (18), p.16461-16470 |
| issn | 1949-2553 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1698961252 |
| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free E- Journals |
| subjects | Cell Proliferation - genetics Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis DNA-Binding Proteins - metabolism Down-Regulation Histone Deacetylase 1 - metabolism Humans Promoter Regions, Genetic - genetics RNA Interference RNA, Messenger - genetics RNA, Small Interfering Stomach Neoplasms - pathology Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - genetics Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism |
| title | By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T22%3A24%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=By%20recruiting%20HDAC1,%20MORC2%20suppresses%20p21%20Waf1/Cip1%20in%20gastric%20cancer&rft.jtitle=Oncotarget&rft.au=Zhang,%20Qing&rft.date=2015-06-30&rft.volume=6&rft.issue=18&rft.spage=16461&rft.epage=16470&rft.pages=16461-16470&rft.eissn=1949-2553&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1698961252%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1698961252&rft_id=info:pmid/26098774&rfr_iscdi=true |