By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer

Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediate...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncotarget 2015-06, Vol.6 (18), p.16461-16470
Hauptverfasser:	Zhang, Qing, Song, Yanyan, Chen, Wei, Wang, Xiaohui, Miao, Zhifeng, Cao, Liu, Li, Feng, Wang, Guiling
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Proliferation - genetics Cyclin-Dependent Kinase Inhibitor p21 - antagonists & inhibitors Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis DNA-Binding Proteins - metabolism Down-Regulation Histone Deacetylase 1 - metabolism Humans Promoter Regions, Genetic - genetics RNA Interference RNA, Messenger - genetics RNA, Small Interfering Stomach Neoplasms - pathology Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic - genetics Tumor Cells, Cultured Tumor Suppressor Protein p53 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.
ISSN:	1949-2553