Functional analyses of the human metallothionein-IG gene. In vitro and in vivo studies

We have analyzed the human (h) metallothionein (MT)-IG proximal promoter region (-174 to +5) using a TATA box mutation (TATCA) and four trinucleotide mutants of the proximal MREa. Transient transfection of HepG2 cells was complemented by in vitro transcription with rat liver nuclear extracts. In bot...

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Veröffentlicht in:	The Journal of biological chemistry 1995-10, Vol.270 (42), p.25194-25199
Hauptverfasser:	Samson, S L, Paramchuk, W J, Shworak, N W, Gedamu, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Deoxyribonuclease I - pharmacology DNA-Binding Proteins - physiology Genes, Regulator Humans Male Metallothionein - genetics Molecular Sequence Data Mutation Promoter Regions, Genetic Rats Rats, Sprague-Dawley TATA Box TATA-Box Binding Protein Transcription Factors - physiology Transcription, Genetic - drug effects Tumor Cells, Cultured Zinc - pharmacology
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