Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex
The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homog...
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| Veröffentlicht in: | Journal of the American Chemical Society 2015-07, Vol.137 (28), p.8888-8891 |
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| container_end_page | 8891 |
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| container_issue | 28 |
| container_start_page | 8888 |
| container_title | Journal of the American Chemical Society |
| container_volume | 137 |
| creator | Mukherjee, Arup Srimani, Dipankar Chakraborty, Subrata Ben-David, Yehoshoa Milstein, David |
| description | The catalytic hydrogenation of nitriles to primary amines represents an atom-efficient and environmentally benign reduction methodology in organic chemistry. This has been accomplished in recent years mainly with precious-metal-based catalysts, with a single exception. Here we report the first homogeneous Co-catalyzed hydrogenation of nitriles to primary amines. Several (hetero)aromatic, benzylic, and aliphatic nitriles undergo hydrogenation to the corresponding primary amines in good to excellent yields under the reaction conditions. |
| doi_str_mv | 10.1021/jacs.5b04879 |
| format | Article |
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| issn | 0002-7863 1520-5126 |
| language | eng |
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| source | ACS Publications |
| title | Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Cobalt Pincer Complex |
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