Nuclear accumulation of p53 in response to treatment with DNA-damaging agents

A number of agents which damage DNA also trigger the nuclear accumulation of the tumor suppressor protein p53. Here we show the correlation with different p53 detection methods. As an example we investigated the effects of the cancer therapy drug mitomycin C on different mammalian cell lines. Our fi...

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Veröffentlicht in:	Toxicology letters 1994-06, Vol.72 (1), p.43-52
Hauptverfasser:	Hess, Ralf, Plaumann, Bettina, Lutum, Annegret Schulze, Haessler, Christel, Heinz, Barbara, Fritsche, Michael, Brandner, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cell Nucleus - metabolism Cells, Cultured Cercopithecus aethiops Chemical agents DNA Damage DNA Nucleotidylexotransferase - metabolism Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Immunoblotting Immunochemistry Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C3H Mitomycin - toxicity p53 p53 nuclear accumulation Tumor Suppressor Protein p53 - analysis Tumor Suppressor Protein p53 - metabolism Tumors
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