The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment
Abstract MicroRNAs (miRNAs) are tiny non-coding RNA molecules that regulate gene expression predominantly at the post-transcriptional level. Far from being simple intracellular regulators, miRNAs have recently been involved in intercellular communication and have been shown to circulate in the blood...
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| Veröffentlicht in: | Atherosclerosis 2015-08, Vol.241 (2), p.624-633 |
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| creator | Economou, Evangelos K Oikonomou, Evangelos Siasos, Gerasimos Papageorgiou, Nikolaos Tsalamandris, Sotiris Mourouzis, Konsantinos Papaioanou, Spyridon Tousoulis, Dimitris |
| description | Abstract MicroRNAs (miRNAs) are tiny non-coding RNA molecules that regulate gene expression predominantly at the post-transcriptional level. Far from being simple intracellular regulators, miRNAs have recently been involved in intercellular communication and have been shown to circulate in the bloodstream in stable forms. In the past years specific miRNA expression patterns have been linked to the development of atherosclerosis and coronary artery disease, two closely related conditions. The study of miRNAs has promoted our understanding of the processes involved in the pathogenesis of atherosclerosis and innovative diagnostic and therapeutic approaches have emerged. In this review, we present the role of miRNAs in the development of atherosclerosis, on coronary artery disease progression and we assess their role as diagnostic biomarkers. Finally we evaluate the therapeutic and preventive opportunities that arise from the study of miRNAs in coronary artery disease and especially in myocardial infarction. |
| doi_str_mv | 10.1016/j.atherosclerosis.2015.06.037 |
| format | Article |
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Far from being simple intracellular regulators, miRNAs have recently been involved in intercellular communication and have been shown to circulate in the bloodstream in stable forms. In the past years specific miRNA expression patterns have been linked to the development of atherosclerosis and coronary artery disease, two closely related conditions. The study of miRNAs has promoted our understanding of the processes involved in the pathogenesis of atherosclerosis and innovative diagnostic and therapeutic approaches have emerged. In this review, we present the role of miRNAs in the development of atherosclerosis, on coronary artery disease progression and we assess their role as diagnostic biomarkers. Finally we evaluate the therapeutic and preventive opportunities that arise from the study of miRNAs in coronary artery disease and especially in myocardial infarction.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2015.06.037</identifier><identifier>PMID: 26117399</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Animals ; Apoptosis ; Atherosclerosis ; Atherosclerosis - diagnosis ; Atherosclerosis - genetics ; Atherosclerosis - physiopathology ; Atherosclerosis - therapy ; Biomarkers - metabolism ; Blood Platelets - cytology ; Cardiovascular ; Cell Movement ; Coronary artery disease ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - genetics ; Coronary Artery Disease - physiopathology ; Coronary Artery Disease - therapy ; Disease Progression ; Endothelium, Vascular - pathology ; Gene Expression Regulation ; Humans ; Lipoproteins, HDL - metabolism ; Lipoproteins, LDL - metabolism ; Mice ; MicroRNAs ; MicroRNAs - metabolism ; Monocytes - cytology ; Muscle, Smooth, Vascular - cytology ; Myocardial infarction ; Myocardial Infarction - metabolism ; Neovascularization, Pathologic ; Oligonucleotides - chemistry ; Reperfusion Injury - pathology ; Stem Cells - cytology</subject><ispartof>Atherosclerosis, 2015-08, Vol.241 (2), p.624-633</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2015 Elsevier Ireland Ltd</rights><rights>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-8dcba917ffdcf6de38d11705d0833640d0511ca456a4f38bdbb73549f80165463</citedby><cites>FETCH-LOGICAL-c510t-8dcba917ffdcf6de38d11705d0833640d0511ca456a4f38bdbb73549f80165463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2015.06.037$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26117399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Economou, Evangelos K</creatorcontrib><creatorcontrib>Oikonomou, Evangelos</creatorcontrib><creatorcontrib>Siasos, Gerasimos</creatorcontrib><creatorcontrib>Papageorgiou, Nikolaos</creatorcontrib><creatorcontrib>Tsalamandris, Sotiris</creatorcontrib><creatorcontrib>Mourouzis, Konsantinos</creatorcontrib><creatorcontrib>Papaioanou, Spyridon</creatorcontrib><creatorcontrib>Tousoulis, Dimitris</creatorcontrib><title>The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract MicroRNAs (miRNAs) are tiny non-coding RNA molecules that regulate gene expression predominantly at the post-transcriptional level. Far from being simple intracellular regulators, miRNAs have recently been involved in intercellular communication and have been shown to circulate in the bloodstream in stable forms. In the past years specific miRNA expression patterns have been linked to the development of atherosclerosis and coronary artery disease, two closely related conditions. The study of miRNAs has promoted our understanding of the processes involved in the pathogenesis of atherosclerosis and innovative diagnostic and therapeutic approaches have emerged. In this review, we present the role of miRNAs in the development of atherosclerosis, on coronary artery disease progression and we assess their role as diagnostic biomarkers. Finally we evaluate the therapeutic and preventive opportunities that arise from the study of miRNAs in coronary artery disease and especially in myocardial infarction.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - diagnosis</subject><subject>Atherosclerosis - genetics</subject><subject>Atherosclerosis - physiopathology</subject><subject>Atherosclerosis - therapy</subject><subject>Biomarkers - metabolism</subject><subject>Blood Platelets - cytology</subject><subject>Cardiovascular</subject><subject>Cell Movement</subject><subject>Coronary artery disease</subject><subject>Coronary Artery Disease - diagnosis</subject><subject>Coronary Artery Disease - genetics</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Coronary Artery Disease - therapy</subject><subject>Disease Progression</subject><subject>Endothelium, Vascular - pathology</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Lipoproteins, HDL - metabolism</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Mice</subject><subject>MicroRNAs</subject><subject>MicroRNAs - metabolism</subject><subject>Monocytes - cytology</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - metabolism</subject><subject>Neovascularization, Pathologic</subject><subject>Oligonucleotides - chemistry</subject><subject>Reperfusion Injury - pathology</subject><subject>Stem Cells - cytology</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-LFDEQxYMo7rj6FSQXwUu3VZ3-kxYUlsVdhUVBV_AW0kn1TsbuZEx6hPn2ppnVw56EkLq8qnrvV4y9QigRsH2zK_WypRiSmdbfpbICbEpoSxDdI7ZB2fUF1rJ-zDYAFRY9NnDGnqW0A4C6Q_mUnVUtYif6fsP07ZZ4DBPxMPLZmRi-fr5I3HluQgxexyPXcaFcrEukE73lVzHMfJ9dhP32mFyYwt2RLyEL9J1fHXHtLV8i6WUmvzxnT0Y9JXpxX8_Z96sPt5cfi5sv158uL24K0yAshbRm0D1242jN2FoS0maP0FiQQrQ1WGgQja6bVtejkIMdhk40dT_KTKWpW3HOXp_m7mP4daC0qNklQ9OkPYVDUtj2EgRUss7SdydpjptSpFHto5tzVoWgVspqpx5QVitlBa3KlHP_y_tVh2Em-6_7L9YsuD4JKAf-7SiqZBx5Q9ZFMouywf33qvcPJpnJeWf09JOOlHbhEH2mqlClSoH6tp58vfj6RI8_xB_wp63s</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Economou, Evangelos K</creator><creator>Oikonomou, Evangelos</creator><creator>Siasos, Gerasimos</creator><creator>Papageorgiou, Nikolaos</creator><creator>Tsalamandris, Sotiris</creator><creator>Mourouzis, Konsantinos</creator><creator>Papaioanou, Spyridon</creator><creator>Tousoulis, Dimitris</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment</title><author>Economou, Evangelos K ; Oikonomou, Evangelos ; Siasos, Gerasimos ; Papageorgiou, Nikolaos ; Tsalamandris, Sotiris ; Mourouzis, Konsantinos ; Papaioanou, Spyridon ; Tousoulis, Dimitris</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-8dcba917ffdcf6de38d11705d0833640d0511ca456a4f38bdbb73549f80165463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis - diagnosis</topic><topic>Atherosclerosis - genetics</topic><topic>Atherosclerosis - physiopathology</topic><topic>Atherosclerosis - therapy</topic><topic>Biomarkers - metabolism</topic><topic>Blood Platelets - cytology</topic><topic>Cardiovascular</topic><topic>Cell Movement</topic><topic>Coronary artery disease</topic><topic>Coronary Artery Disease - diagnosis</topic><topic>Coronary Artery Disease - genetics</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Coronary Artery Disease - therapy</topic><topic>Disease Progression</topic><topic>Endothelium, Vascular - pathology</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Lipoproteins, HDL - metabolism</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>Mice</topic><topic>MicroRNAs</topic><topic>MicroRNAs - metabolism</topic><topic>Monocytes - cytology</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - metabolism</topic><topic>Neovascularization, Pathologic</topic><topic>Oligonucleotides - chemistry</topic><topic>Reperfusion Injury - pathology</topic><topic>Stem Cells - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Economou, Evangelos K</creatorcontrib><creatorcontrib>Oikonomou, Evangelos</creatorcontrib><creatorcontrib>Siasos, Gerasimos</creatorcontrib><creatorcontrib>Papageorgiou, Nikolaos</creatorcontrib><creatorcontrib>Tsalamandris, Sotiris</creatorcontrib><creatorcontrib>Mourouzis, Konsantinos</creatorcontrib><creatorcontrib>Papaioanou, Spyridon</creatorcontrib><creatorcontrib>Tousoulis, Dimitris</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Economou, Evangelos K</au><au>Oikonomou, Evangelos</au><au>Siasos, Gerasimos</au><au>Papageorgiou, Nikolaos</au><au>Tsalamandris, Sotiris</au><au>Mourouzis, Konsantinos</au><au>Papaioanou, Spyridon</au><au>Tousoulis, Dimitris</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>241</volume><issue>2</issue><spage>624</spage><epage>633</epage><pages>624-633</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract MicroRNAs (miRNAs) are tiny non-coding RNA molecules that regulate gene expression predominantly at the post-transcriptional level. 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| subjects | Animals Apoptosis Atherosclerosis Atherosclerosis - diagnosis Atherosclerosis - genetics Atherosclerosis - physiopathology Atherosclerosis - therapy Biomarkers - metabolism Blood Platelets - cytology Cardiovascular Cell Movement Coronary artery disease Coronary Artery Disease - diagnosis Coronary Artery Disease - genetics Coronary Artery Disease - physiopathology Coronary Artery Disease - therapy Disease Progression Endothelium, Vascular - pathology Gene Expression Regulation Humans Lipoproteins, HDL - metabolism Lipoproteins, LDL - metabolism Mice MicroRNAs MicroRNAs - metabolism Monocytes - cytology Muscle, Smooth, Vascular - cytology Myocardial infarction Myocardial Infarction - metabolism Neovascularization, Pathologic Oligonucleotides - chemistry Reperfusion Injury - pathology Stem Cells - cytology |
| title | The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment |
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