The association between antiphospholipid antibodies and pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature
In a previous systematic literature search, we demonstrated that the frequencies of antiphospholipid antibodies (aPL) in general-population patients with pregnancy morbidity (PM), deep vein thrombosis (DVT), myocardial infarction (MI), and stroke (ST) are 6%, 10%, 11%, and 14%. To determine the asso...
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| Veröffentlicht in: | Lupus 2015-08, Vol.24 (9), p.980-984 |
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| creator | Chighizola, C B Andreoli, L de Jesus, G Ramires Banzato, A Pons-Estel, G J Erkan, D |
| description | In a previous systematic literature search, we demonstrated that the frequencies of antiphospholipid antibodies (aPL) in general-population patients with pregnancy morbidity (PM), deep vein thrombosis (DVT), myocardial infarction (MI), and stroke (ST) are 6%, 10%, 11%, and 14%. To determine the association between aPL and clinical outcomes, we conducted a follow-up analysis of the 120 studies included in the original paper. Based on the analysis of 81 studies, a significant difference in the frequency of aPL criteria tests between patients and controls emerged considering all the outcomes together (10% versus 3%). In particular, a significant difference was reported for overall PM, pregnancy loss (PrL), late PrL, severe preeclampsia (PEC), ST, MI, and DVT. No difference emerged for early PrL, intrauterine growth restriction (IUGR), PEC, eclampsia (EC), and HELLP. A positive association was found in more than half of the studies for overall PrL, severe PEC, HELLP, ST, MI, and DVT and in less than half for early and late PrL, PEC, EC, and IUGR. The positive association between aPL and clinical outcomes included in the antiphospholipid syndrome classification criteria is not supported by every study, being particularly inconsistent for early PL, IUGR, PEC, EC, and HELLP. |
| doi_str_mv | 10.1177/0961203315572714 |
| format | Article |
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To determine the association between aPL and clinical outcomes, we conducted a follow-up analysis of the 120 studies included in the original paper. Based on the analysis of 81 studies, a significant difference in the frequency of aPL criteria tests between patients and controls emerged considering all the outcomes together (10% versus 3%). In particular, a significant difference was reported for overall PM, pregnancy loss (PrL), late PrL, severe preeclampsia (PEC), ST, MI, and DVT. No difference emerged for early PrL, intrauterine growth restriction (IUGR), PEC, eclampsia (EC), and HELLP. A positive association was found in more than half of the studies for overall PrL, severe PEC, HELLP, ST, MI, and DVT and in less than half for early and late PrL, PEC, EC, and IUGR. The positive association between aPL and clinical outcomes included in the antiphospholipid syndrome classification criteria is not supported by every study, being particularly inconsistent for early PL, IUGR, PEC, EC, and HELLP.</description><identifier>ISSN: 0961-2033</identifier><identifier>EISSN: 1477-0962</identifier><identifier>DOI: 10.1177/0961203315572714</identifier><identifier>PMID: 25697769</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Abortion, Spontaneous - immunology ; Antibodies ; Antibodies, Antiphospholipid - immunology ; Antiphospholipid Syndrome - immunology ; Chi-square test ; Clinical outcomes ; Eclampsia ; Female ; Fetal Growth Retardation - immunology ; Heart attacks ; Humans ; Literature reviews ; Lupus ; Lupus Coagulation Inhibitor ; Morbidity ; Myocardial Infarction - immunology ; Pre-Eclampsia - immunology ; Preeclampsia ; Pregnancy ; Pregnancy Complications - immunology ; Pregnancy Outcome ; Stroke ; Stroke - immunology ; Thrombosis ; Venous Thrombosis - immunology ; Womens health</subject><ispartof>Lupus, 2015-08, Vol.24 (9), p.980-984</ispartof><rights>The Author(s) 2015</rights><rights>The Author(s) 2015.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-3f6f51e77d14d07882886b75b3f3ab6d5254058306d87318d168db1023d8c8263</citedby><cites>FETCH-LOGICAL-c365t-3f6f51e77d14d07882886b75b3f3ab6d5254058306d87318d168db1023d8c8263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/0961203315572714$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/0961203315572714$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25697769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chighizola, C B</creatorcontrib><creatorcontrib>Andreoli, L</creatorcontrib><creatorcontrib>de Jesus, G Ramires</creatorcontrib><creatorcontrib>Banzato, A</creatorcontrib><creatorcontrib>Pons-Estel, G J</creatorcontrib><creatorcontrib>Erkan, D</creatorcontrib><creatorcontrib>APS ACTION</creatorcontrib><title>The association between antiphospholipid antibodies and pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature</title><title>Lupus</title><addtitle>Lupus</addtitle><description>In a previous systematic literature search, we demonstrated that the frequencies of antiphospholipid antibodies (aPL) in general-population patients with pregnancy morbidity (PM), deep vein thrombosis (DVT), myocardial infarction (MI), and stroke (ST) are 6%, 10%, 11%, and 14%. To determine the association between aPL and clinical outcomes, we conducted a follow-up analysis of the 120 studies included in the original paper. Based on the analysis of 81 studies, a significant difference in the frequency of aPL criteria tests between patients and controls emerged considering all the outcomes together (10% versus 3%). In particular, a significant difference was reported for overall PM, pregnancy loss (PrL), late PrL, severe preeclampsia (PEC), ST, MI, and DVT. No difference emerged for early PrL, intrauterine growth restriction (IUGR), PEC, eclampsia (EC), and HELLP. A positive association was found in more than half of the studies for overall PrL, severe PEC, HELLP, ST, MI, and DVT and in less than half for early and late PrL, PEC, EC, and IUGR. The positive association between aPL and clinical outcomes included in the antiphospholipid syndrome classification criteria is not supported by every study, being particularly inconsistent for early PL, IUGR, PEC, EC, and HELLP.</description><subject>Abortion, Spontaneous - immunology</subject><subject>Antibodies</subject><subject>Antibodies, Antiphospholipid - immunology</subject><subject>Antiphospholipid Syndrome - immunology</subject><subject>Chi-square test</subject><subject>Clinical outcomes</subject><subject>Eclampsia</subject><subject>Female</subject><subject>Fetal Growth Retardation - immunology</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Literature reviews</subject><subject>Lupus</subject><subject>Lupus Coagulation Inhibitor</subject><subject>Morbidity</subject><subject>Myocardial Infarction - immunology</subject><subject>Pre-Eclampsia - immunology</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - immunology</subject><subject>Pregnancy Outcome</subject><subject>Stroke</subject><subject>Stroke - immunology</subject><subject>Thrombosis</subject><subject>Venous Thrombosis - immunology</subject><subject>Womens health</subject><issn>0961-2033</issn><issn>1477-0962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtv1DAUhS0EosPAnhWyxIbFhPqR2A47VPGoVKmbso78uOm4JHGwnVbzk_iXOJ2CUKUuLFv3fudc6x6E3lLykVIpT0krKCOc06aRTNL6GdrQWsqq1NlztFnb1do_Qa9SuiGEcNqKl-iENaKVUrQb9PtqD1inFKzX2YcJG8h3ABPWU_bzPqRyBj97d18wwXlI5enwHOF60pM94DFE453Phx1OOYafsMPjIVgdndcD9lOvo12td_c6BzDjW_ATzvsYRhOST5-wxjb67G0RRLj1cIdDXwDAg88QdV4ivEYvej0kePNwb9GPr1-uzr5XF5ffzs8-X1SWiyZXvBd9Q0FKR2tHpFJMKWFkY3jPtRGuYU1NGsWJcEpyqhwVyhlKGHfKKib4Fn04-s4x_Fog5W70ycIw6AnCkjoqWkWYKvsv6PtH6E1Y4lR-t1Ito6wu298icqRsDClF6Ls5-lHHQ0dJt8bYPY6xSN49GC9mBPdP8De3AlRHIOlr-G_qU4Z_AEuXprA</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Chighizola, C B</creator><creator>Andreoli, L</creator><creator>de Jesus, G Ramires</creator><creator>Banzato, A</creator><creator>Pons-Estel, G J</creator><creator>Erkan, D</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>The association between antiphospholipid antibodies and pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature</title><author>Chighizola, C B ; Andreoli, L ; de Jesus, G Ramires ; Banzato, A ; Pons-Estel, G J ; Erkan, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-3f6f51e77d14d07882886b75b3f3ab6d5254058306d87318d168db1023d8c8263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abortion, Spontaneous - immunology</topic><topic>Antibodies</topic><topic>Antibodies, Antiphospholipid - immunology</topic><topic>Antiphospholipid Syndrome - immunology</topic><topic>Chi-square test</topic><topic>Clinical outcomes</topic><topic>Eclampsia</topic><topic>Female</topic><topic>Fetal Growth Retardation - immunology</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Literature reviews</topic><topic>Lupus</topic><topic>Lupus Coagulation Inhibitor</topic><topic>Morbidity</topic><topic>Myocardial Infarction - immunology</topic><topic>Pre-Eclampsia - immunology</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - immunology</topic><topic>Pregnancy Outcome</topic><topic>Stroke</topic><topic>Stroke - immunology</topic><topic>Thrombosis</topic><topic>Venous Thrombosis - immunology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chighizola, C B</creatorcontrib><creatorcontrib>Andreoli, L</creatorcontrib><creatorcontrib>de Jesus, G Ramires</creatorcontrib><creatorcontrib>Banzato, A</creatorcontrib><creatorcontrib>Pons-Estel, G J</creatorcontrib><creatorcontrib>Erkan, D</creatorcontrib><creatorcontrib>APS ACTION</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Lupus</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chighizola, C B</au><au>Andreoli, L</au><au>de Jesus, G Ramires</au><au>Banzato, A</au><au>Pons-Estel, G J</au><au>Erkan, D</au><aucorp>APS ACTION</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association between antiphospholipid antibodies and pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature</atitle><jtitle>Lupus</jtitle><addtitle>Lupus</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>24</volume><issue>9</issue><spage>980</spage><epage>984</epage><pages>980-984</pages><issn>0961-2033</issn><eissn>1477-0962</eissn><abstract>In a previous systematic literature search, we demonstrated that the frequencies of antiphospholipid antibodies (aPL) in general-population patients with pregnancy morbidity (PM), deep vein thrombosis (DVT), myocardial infarction (MI), and stroke (ST) are 6%, 10%, 11%, and 14%. To determine the association between aPL and clinical outcomes, we conducted a follow-up analysis of the 120 studies included in the original paper. Based on the analysis of 81 studies, a significant difference in the frequency of aPL criteria tests between patients and controls emerged considering all the outcomes together (10% versus 3%). In particular, a significant difference was reported for overall PM, pregnancy loss (PrL), late PrL, severe preeclampsia (PEC), ST, MI, and DVT. No difference emerged for early PrL, intrauterine growth restriction (IUGR), PEC, eclampsia (EC), and HELLP. A positive association was found in more than half of the studies for overall PrL, severe PEC, HELLP, ST, MI, and DVT and in less than half for early and late PrL, PEC, EC, and IUGR. The positive association between aPL and clinical outcomes included in the antiphospholipid syndrome classification criteria is not supported by every study, being particularly inconsistent for early PL, IUGR, PEC, EC, and HELLP.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>25697769</pmid><doi>10.1177/0961203315572714</doi><tpages>5</tpages></addata></record> |
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| subjects | Abortion, Spontaneous - immunology Antibodies Antibodies, Antiphospholipid - immunology Antiphospholipid Syndrome - immunology Chi-square test Clinical outcomes Eclampsia Female Fetal Growth Retardation - immunology Heart attacks Humans Literature reviews Lupus Lupus Coagulation Inhibitor Morbidity Myocardial Infarction - immunology Pre-Eclampsia - immunology Preeclampsia Pregnancy Pregnancy Complications - immunology Pregnancy Outcome Stroke Stroke - immunology Thrombosis Venous Thrombosis - immunology Womens health |
| title | The association between antiphospholipid antibodies and pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature |
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