Transcriptional Regulation of the Human GLUT4 Gene Promoter in Diabetic Transgenic Mice (∗)

We previously reported that 2400 base pairs (bp) of 5′-flanking DNA is sufficient for tissue-specific and hormonal/metabolic regulation of the human GLUT4 gene in transgenic mice (Liu, M.-L., Olson, A. L., Moye-Rowley, W. S., Buse, J. B., Bell, G. I., and Pessin, J. E.(1992) J. Biol. Chem. 267, 1167...

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Veröffentlicht in:	The Journal of biological chemistry 1995-10, Vol.270 (40), p.23491-23495
Hauptverfasser:	Olson, Ann Louise, Pessin, Jeffery E.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACILTRANSFERASA ACYLTRANSFERASE ACYLTRANSFERASES Adipose Tissue - metabolism ADIPOSE TISSUES ADN RECOMBINADO ADN RECOMBINE ANIMAL TRANSGENIQUE ANIMALES TRANSGENICOS Animals ARN MENSAJERO ARN MESSAGER BRAIN BROWN FAT CEREBRO CHLORAMPHENICOL ACETYLTRANSFERASE Chloramphenicol O-Acetyltransferase - genetics DELETIONS DIABETE DIABETES Diabetes Mellitus, Experimental - genetics DNA, Recombinant - genetics ENCEPHALE EXPERIMENTACION EXPERIMENTATION EXPRESION GENICA EXPRESSION DES GENES FOIE GENE GENE EXPRESSION Gene Expression Regulation gene regulation GENERO HUMANO GENES GENETIC REGULATION GENETICA GENETICS GENETIQUE GENRE HUMAIN GLUCOSE TRANSPORTER Glucose Transporter Type 4 GLUT4 gene HIGADO Humans INSULIN INSULINA INSULINE LIVER MANKIND MESSENGER RNA MICE Mice, Transgenic Monosaccharide Transport Proteins - genetics MUSCLE Muscle Proteins Muscle, Skeletal - metabolism MUSCLES MUSCULOS Myocardium - metabolism Promoter Regions, Genetic PROTEINAS PROTEINE PROTEINS RATON RECOMBINANT DNA REPORTER GENES RNA RNA, Messenger - genetics RNA, Messenger - metabolism SKELETAL MUSCLE SOURIS STREPTOZOTOCIN INDUCED DIABETES SURFACE PROTEINS TEJIDO ADIPOSO TISSU ADIPEUX Tissue Distribution TRANSCRIPCION TRANSCRIPTION TRANSGENIC ANIMALS transgenic mice
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