Case-Control Study of Squamous Cell Cancer of the Oral Cavity in Denmark
A population-based case-control study was designed to examine if the risk of developing intra-oral squamous-cell carcinoma in Denmark was associated with occupation, marital status, residence, dental status, and exposure to coffee, tea, tobacco, and alcohol. Cases consisted of 161 consecutively-admi...
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| Veröffentlicht in: | Cancer causes & control 1995-01, Vol.6 (1), p.57-67 |
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| creator | Bundgaard, Troels Wildt, John Frydenberg, Morten Elbrønd, Ole Nielsen, Jens Erik |
| description | A population-based case-control study was designed to examine if the risk of developing intra-oral squamous-cell carcinoma in Denmark was associated with occupation, marital status, residence, dental status, and exposure to coffee, tea, tobacco, and alcohol. Cases consisted of 161 consecutively-admitted incident patients with histologically verified, primary, intra-oral squamous-cell carcinoma treated at the Aarhus University Hospital from January 1986 to November 1990. For each case, three controls of the same gender and age were selected randomly from among nonhospitalized residents in the hospital's catchment area (some 1.4 m inhabitants). Four hundred of the selected 483 controls participated in the study. Risk was associated significantly with marital status, residence, dental status, alcohol consumption, and exposure to tobacco. When correcting for tobacco and alcohol consumption, only marital status and dental status remained significant. The association between risk and marital status was particularly prominent among divorced compared with married persons (odds ratio [OR] = 2.3, 95 percent confidence interval [CI] = 1.1-4.6). Persons with less than five teeth had an OR of 2.4 (CI 1.3-4.1) compared with persons with 15 or more teeth. Tobacco and alcohol exposure were the strongest individual risk-indicators in both lifetime and current consumption estimates, and their composite effect was particularly strong. Compared with nonusers, OR for tobacco (> 20 g/d) adjusted for alcohol = 5.8 (CI = 3.1-10.9); OR for alcohol (> 5 drinks/d) adjusted for tobacco = 8.4 (CI = 4.0-17.6). The OR for heavy users of tobacco and alcohol (> 20 g tobacco/d and > 5 drinks/d) was 80.7 (CI = 21.8-298.8). These results confirm that tobacco and alcohol contribute significantly to the risk of developing oral cancer. There were no significant differences between the risk estimates for the two genders or young and old persons. Two simulation studies indicate that the observed risk associated with tobacco and alcohol consumption cannot be explained reasonably by a high consumption among the 83 nonrespondents. |
| doi_str_mv | 10.1007/BF00051681 |
| format | Article |
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Cases consisted of 161 consecutively-admitted incident patients with histologically verified, primary, intra-oral squamous-cell carcinoma treated at the Aarhus University Hospital from January 1986 to November 1990. For each case, three controls of the same gender and age were selected randomly from among nonhospitalized residents in the hospital's catchment area (some 1.4 m inhabitants). Four hundred of the selected 483 controls participated in the study. Risk was associated significantly with marital status, residence, dental status, alcohol consumption, and exposure to tobacco. When correcting for tobacco and alcohol consumption, only marital status and dental status remained significant. The association between risk and marital status was particularly prominent among divorced compared with married persons (odds ratio [OR] = 2.3, 95 percent confidence interval [CI] = 1.1-4.6). Persons with less than five teeth had an OR of 2.4 (CI 1.3-4.1) compared with persons with 15 or more teeth. Tobacco and alcohol exposure were the strongest individual risk-indicators in both lifetime and current consumption estimates, and their composite effect was particularly strong. Compared with nonusers, OR for tobacco (> 20 g/d) adjusted for alcohol = 5.8 (CI = 3.1-10.9); OR for alcohol (> 5 drinks/d) adjusted for tobacco = 8.4 (CI = 4.0-17.6). The OR for heavy users of tobacco and alcohol (> 20 g tobacco/d and > 5 drinks/d) was 80.7 (CI = 21.8-298.8). These results confirm that tobacco and alcohol contribute significantly to the risk of developing oral cancer. There were no significant differences between the risk estimates for the two genders or young and old persons. Two simulation studies indicate that the observed risk associated with tobacco and alcohol consumption cannot be explained reasonably by a high consumption among the 83 nonrespondents.</description><identifier>ISSN: 0957-5243</identifier><identifier>EISSN: 1573-7225</identifier><identifier>DOI: 10.1007/BF00051681</identifier><identifier>PMID: 7718736</identifier><language>eng</language><publisher>Netherlands: Rapid Communications Oxford-New York</publisher><subject>Adult ; Aged ; Alcohol Drinking ; Alcoholic beverages ; Alcohols ; Cancer ; Carcinoma, Squamous Cell - epidemiology ; Case-Control Studies ; Catchment Area (Health) ; Cigarettes ; Coffee ; Denmark - epidemiology ; Female ; Humans ; Incidence ; Logistic Models ; Male ; Marital Status ; Middle Aged ; Mouth ; Mouth neoplasms ; Mouth Neoplasms - epidemiology ; Multivariate Analysis ; Occupations ; Oral Health ; Research Papers ; Risk Factors ; Smoking ; Squamous cell carcinoma ; Tea ; Teeth</subject><ispartof>Cancer causes & control, 1995-01, Vol.6 (1), p.57-67</ispartof><rights>Copyright 1995 Rapid Communications of Oxford Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3552892$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3552892$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27928,27929,58021,58254</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7718736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bundgaard, Troels</creatorcontrib><creatorcontrib>Wildt, John</creatorcontrib><creatorcontrib>Frydenberg, Morten</creatorcontrib><creatorcontrib>Elbrønd, Ole</creatorcontrib><creatorcontrib>Nielsen, Jens Erik</creatorcontrib><title>Case-Control Study of Squamous Cell Cancer of the Oral Cavity in Denmark</title><title>Cancer causes & control</title><addtitle>Cancer Causes Control</addtitle><description>A population-based case-control study was designed to examine if the risk of developing intra-oral squamous-cell carcinoma in Denmark was associated with occupation, marital status, residence, dental status, and exposure to coffee, tea, tobacco, and alcohol. Cases consisted of 161 consecutively-admitted incident patients with histologically verified, primary, intra-oral squamous-cell carcinoma treated at the Aarhus University Hospital from January 1986 to November 1990. For each case, three controls of the same gender and age were selected randomly from among nonhospitalized residents in the hospital's catchment area (some 1.4 m inhabitants). Four hundred of the selected 483 controls participated in the study. Risk was associated significantly with marital status, residence, dental status, alcohol consumption, and exposure to tobacco. When correcting for tobacco and alcohol consumption, only marital status and dental status remained significant. The association between risk and marital status was particularly prominent among divorced compared with married persons (odds ratio [OR] = 2.3, 95 percent confidence interval [CI] = 1.1-4.6). Persons with less than five teeth had an OR of 2.4 (CI 1.3-4.1) compared with persons with 15 or more teeth. Tobacco and alcohol exposure were the strongest individual risk-indicators in both lifetime and current consumption estimates, and their composite effect was particularly strong. Compared with nonusers, OR for tobacco (> 20 g/d) adjusted for alcohol = 5.8 (CI = 3.1-10.9); OR for alcohol (> 5 drinks/d) adjusted for tobacco = 8.4 (CI = 4.0-17.6). The OR for heavy users of tobacco and alcohol (> 20 g tobacco/d and > 5 drinks/d) was 80.7 (CI = 21.8-298.8). These results confirm that tobacco and alcohol contribute significantly to the risk of developing oral cancer. There were no significant differences between the risk estimates for the two genders or young and old persons. Two simulation studies indicate that the observed risk associated with tobacco and alcohol consumption cannot be explained reasonably by a high consumption among the 83 nonrespondents.</description><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Case-Control Studies</subject><subject>Catchment Area (Health)</subject><subject>Cigarettes</subject><subject>Coffee</subject><subject>Denmark - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Marital Status</subject><subject>Middle Aged</subject><subject>Mouth</subject><subject>Mouth neoplasms</subject><subject>Mouth Neoplasms - epidemiology</subject><subject>Multivariate Analysis</subject><subject>Occupations</subject><subject>Oral Health</subject><subject>Research Papers</subject><subject>Risk Factors</subject><subject>Smoking</subject><subject>Squamous cell carcinoma</subject><subject>Tea</subject><subject>Teeth</subject><issn>0957-5243</issn><issn>1573-7225</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9jztPwzAUhS0EKqWwMIPkiS3gR67tjBAoRarUoTBHjmuLlDxa20HqvydRK6YrnfPp6LsI3VLySAmRTy9zQghQoegZmlKQPJGMwTmakgxkAizll-gqhO1ICUYmaCIlVZKLKVrkOtgk79rouxqvY7854M7h9b7XTdcHnNu6xrlujfVjHr8tXnk9Rr9VPOCqxa-2bbT_uUYXTtfB3pzuDH3N3z7zRbJcvX_kz8tkSyGLiSqlE4NiKrgz2UYLTRWF0jmlSAlWGWZASm4cEdJYCtYY5bI0NZwoAobyGXo47u58t-9tiEVTBTNY6tYOwgUVmVQc0gG8P4F92dhNsfPV4HkoTq8P_d2x34bY-f-aAzCVMf4H88Vh1w</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>Bundgaard, Troels</creator><creator>Wildt, John</creator><creator>Frydenberg, Morten</creator><creator>Elbrønd, Ole</creator><creator>Nielsen, Jens Erik</creator><general>Rapid Communications Oxford-New York</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19950101</creationdate><title>Case-Control Study of Squamous Cell Cancer of the Oral Cavity in Denmark</title><author>Bundgaard, Troels ; Wildt, John ; Frydenberg, Morten ; Elbrønd, Ole ; Nielsen, Jens Erik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j159t-8b7f6157463fc9da6a1815bff880b5e8c2c5773cf067ce15ecc8f944c30805c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking</topic><topic>Alcoholic beverages</topic><topic>Alcohols</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Case-Control Studies</topic><topic>Catchment Area (Health)</topic><topic>Cigarettes</topic><topic>Coffee</topic><topic>Denmark - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Marital Status</topic><topic>Middle Aged</topic><topic>Mouth</topic><topic>Mouth neoplasms</topic><topic>Mouth Neoplasms - epidemiology</topic><topic>Multivariate Analysis</topic><topic>Occupations</topic><topic>Oral Health</topic><topic>Research Papers</topic><topic>Risk Factors</topic><topic>Smoking</topic><topic>Squamous cell carcinoma</topic><topic>Tea</topic><topic>Teeth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bundgaard, Troels</creatorcontrib><creatorcontrib>Wildt, John</creatorcontrib><creatorcontrib>Frydenberg, Morten</creatorcontrib><creatorcontrib>Elbrønd, Ole</creatorcontrib><creatorcontrib>Nielsen, Jens Erik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer causes & control</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bundgaard, Troels</au><au>Wildt, John</au><au>Frydenberg, Morten</au><au>Elbrønd, Ole</au><au>Nielsen, Jens Erik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Case-Control Study of Squamous Cell Cancer of the Oral Cavity in Denmark</atitle><jtitle>Cancer causes & control</jtitle><addtitle>Cancer Causes Control</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>6</volume><issue>1</issue><spage>57</spage><epage>67</epage><pages>57-67</pages><issn>0957-5243</issn><eissn>1573-7225</eissn><abstract>A population-based case-control study was designed to examine if the risk of developing intra-oral squamous-cell carcinoma in Denmark was associated with occupation, marital status, residence, dental status, and exposure to coffee, tea, tobacco, and alcohol. Cases consisted of 161 consecutively-admitted incident patients with histologically verified, primary, intra-oral squamous-cell carcinoma treated at the Aarhus University Hospital from January 1986 to November 1990. For each case, three controls of the same gender and age were selected randomly from among nonhospitalized residents in the hospital's catchment area (some 1.4 m inhabitants). Four hundred of the selected 483 controls participated in the study. Risk was associated significantly with marital status, residence, dental status, alcohol consumption, and exposure to tobacco. When correcting for tobacco and alcohol consumption, only marital status and dental status remained significant. The association between risk and marital status was particularly prominent among divorced compared with married persons (odds ratio [OR] = 2.3, 95 percent confidence interval [CI] = 1.1-4.6). Persons with less than five teeth had an OR of 2.4 (CI 1.3-4.1) compared with persons with 15 or more teeth. Tobacco and alcohol exposure were the strongest individual risk-indicators in both lifetime and current consumption estimates, and their composite effect was particularly strong. Compared with nonusers, OR for tobacco (> 20 g/d) adjusted for alcohol = 5.8 (CI = 3.1-10.9); OR for alcohol (> 5 drinks/d) adjusted for tobacco = 8.4 (CI = 4.0-17.6). The OR for heavy users of tobacco and alcohol (> 20 g tobacco/d and > 5 drinks/d) was 80.7 (CI = 21.8-298.8). These results confirm that tobacco and alcohol contribute significantly to the risk of developing oral cancer. There were no significant differences between the risk estimates for the two genders or young and old persons. Two simulation studies indicate that the observed risk associated with tobacco and alcohol consumption cannot be explained reasonably by a high consumption among the 83 nonrespondents.</abstract><cop>Netherlands</cop><pub>Rapid Communications Oxford-New York</pub><pmid>7718736</pmid><doi>10.1007/BF00051681</doi><tpages>11</tpages></addata></record> |
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| subjects | Adult Aged Alcohol Drinking Alcoholic beverages Alcohols Cancer Carcinoma, Squamous Cell - epidemiology Case-Control Studies Catchment Area (Health) Cigarettes Coffee Denmark - epidemiology Female Humans Incidence Logistic Models Male Marital Status Middle Aged Mouth Mouth neoplasms Mouth Neoplasms - epidemiology Multivariate Analysis Occupations Oral Health Research Papers Risk Factors Smoking Squamous cell carcinoma Tea Teeth |
| title | Case-Control Study of Squamous Cell Cancer of the Oral Cavity in Denmark |
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