Novel action of retinoic acid: stabilization of newly synthesized alkaline phosphatase transcripts

Several observations led us to investigate the possibility that retinoic acid achieved its marked induction of alkaline phosphatase gene expression through a posttranscriptional effect in the nuclei of clonal rat pre-osteoblastic UMR 201 cells. The steady-state level of alkaline phosphatase mRNA was...

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Veröffentlicht in:	The Journal of biological chemistry 1994-09, Vol.269 (35), p.22433-22439
Hauptverfasser:	Zhou, H. (The University of Melbourne, Fitzroy, Victoria, Australia.), Manji, S.S, Findlay, D.M, Martin, T.J, Heath, J.K, Ng, K.W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - genetics Alkaline Phosphatase - metabolism Animals ARN MENSAJERO ARN MESSAGER Base Sequence Cell Nucleus - drug effects Cell Nucleus - enzymology Cells, Cultured CULTIVO DE CELULAS CULTURE DE CELLULE DNA Primers EXPRESION GENICA EXPRESSION DES GENES FOSFATASA ALCALINA Molecular Sequence Data PHOSPHATASE ALCALINE Rats RETINOL RNA Precursors - metabolism RNA Processing, Post-Transcriptional - drug effects RNA, Messenger - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Subcellular Fractions - enzymology Transcription, Genetic - drug effects Transforming Growth Factor beta - pharmacology Tretinoin - pharmacology
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