Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation
Intraductal tubulopapillary neoplasm (ITPN) is a rare pancreatic tumor belonging to a newly recognized entity that is coined in the 2010 WHO classification. We present a case of ITPN-associated microinvasive adenocarcinoma that developed in an asymptomatic 78-year-old patient. The tumor demonstrated...
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| Veröffentlicht in: | Clinical journal of gastroenterology 2012-12, Vol.5 (6), p.413-420 |
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| creator | Urata, Takahiro Naito, Yoshiki Nagamine, Michiko Izumi, Yoshihiro Tonaki, Ginga Iwasaki, Hajime Sasaki, Akiko Yamasaki, Akira Minami, Nobuhiro Yoshioka, Rituko Kitada, Hideki Takekuma, Yoshi Yokomizo, Hiroshi Fukuda, Seiji Yamaguchi, Hiroshi Kuboki, Yuko Furukawa, Toru Hifumi, Michio |
| description | Intraductal tubulopapillary neoplasm (ITPN) is a rare pancreatic tumor belonging to a newly recognized entity that is coined in the 2010 WHO classification. We present a case of ITPN-associated microinvasive adenocarcinoma that developed in an asymptomatic 78-year-old patient. The tumor demonstrated all the clinical, radiological, and pathological characteristics of ITPN, but it differs from other reported cases of ITPN in molecular analysis, which revealed a somatic mutation in
BRAF
(c.1799T>A; p.V600E) but no mutation in
PIK3CA
. Post-operative recurrence was discovered 34 months after tumor resection with negative margins and a 6-month course of adjuvant chemotherapy. To the best of our knowledge, this is the first case of ITPN with
BRAF
mutation. This case suggests that an activation of RAS-mitogen-activated protein kinase signaling pathway may play a role in development of some of ITPNs. A possible mechanism of tumor recurrence in ITPN is also discussed. Further case series with molecular study are awaited to delineate the clinicopathological and molecular characteristics of ITPN. |
| doi_str_mv | 10.1007/s12328-012-0342-1 |
| format | Article |
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BRAF
(c.1799T>A; p.V600E) but no mutation in
PIK3CA
. Post-operative recurrence was discovered 34 months after tumor resection with negative margins and a 6-month course of adjuvant chemotherapy. To the best of our knowledge, this is the first case of ITPN with
BRAF
mutation. This case suggests that an activation of RAS-mitogen-activated protein kinase signaling pathway may play a role in development of some of ITPNs. A possible mechanism of tumor recurrence in ITPN is also discussed. Further case series with molecular study are awaited to delineate the clinicopathological and molecular characteristics of ITPN.</description><identifier>ISSN: 1865-7257</identifier><identifier>EISSN: 1865-7265</identifier><identifier>DOI: 10.1007/s12328-012-0342-1</identifier><identifier>PMID: 26181322</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Abdominal Surgery ; Case Report ; Colorectal Surgery ; Gastroenterology ; Hepatology ; Medicine ; Medicine & Public Health ; Surgical Oncology</subject><ispartof>Clinical journal of gastroenterology, 2012-12, Vol.5 (6), p.413-420</ispartof><rights>Springer Japan 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-74e1c1535aec98fd8bf4d96a10f07638f8daa41735d44d6978a6769f2415862a3</citedby><cites>FETCH-LOGICAL-c344t-74e1c1535aec98fd8bf4d96a10f07638f8daa41735d44d6978a6769f2415862a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12328-012-0342-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12328-012-0342-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26181322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Urata, Takahiro</creatorcontrib><creatorcontrib>Naito, Yoshiki</creatorcontrib><creatorcontrib>Nagamine, Michiko</creatorcontrib><creatorcontrib>Izumi, Yoshihiro</creatorcontrib><creatorcontrib>Tonaki, Ginga</creatorcontrib><creatorcontrib>Iwasaki, Hajime</creatorcontrib><creatorcontrib>Sasaki, Akiko</creatorcontrib><creatorcontrib>Yamasaki, Akira</creatorcontrib><creatorcontrib>Minami, Nobuhiro</creatorcontrib><creatorcontrib>Yoshioka, Rituko</creatorcontrib><creatorcontrib>Kitada, Hideki</creatorcontrib><creatorcontrib>Takekuma, Yoshi</creatorcontrib><creatorcontrib>Yokomizo, Hiroshi</creatorcontrib><creatorcontrib>Fukuda, Seiji</creatorcontrib><creatorcontrib>Yamaguchi, Hiroshi</creatorcontrib><creatorcontrib>Kuboki, Yuko</creatorcontrib><creatorcontrib>Furukawa, Toru</creatorcontrib><creatorcontrib>Hifumi, Michio</creatorcontrib><title>Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation</title><title>Clinical journal of gastroenterology</title><addtitle>Clin J Gastroenterol</addtitle><addtitle>Clin J Gastroenterol</addtitle><description>Intraductal tubulopapillary neoplasm (ITPN) is a rare pancreatic tumor belonging to a newly recognized entity that is coined in the 2010 WHO classification. We present a case of ITPN-associated microinvasive adenocarcinoma that developed in an asymptomatic 78-year-old patient. The tumor demonstrated all the clinical, radiological, and pathological characteristics of ITPN, but it differs from other reported cases of ITPN in molecular analysis, which revealed a somatic mutation in
BRAF
(c.1799T>A; p.V600E) but no mutation in
PIK3CA
. Post-operative recurrence was discovered 34 months after tumor resection with negative margins and a 6-month course of adjuvant chemotherapy. To the best of our knowledge, this is the first case of ITPN with
BRAF
mutation. This case suggests that an activation of RAS-mitogen-activated protein kinase signaling pathway may play a role in development of some of ITPNs. A possible mechanism of tumor recurrence in ITPN is also discussed. Further case series with molecular study are awaited to delineate the clinicopathological and molecular characteristics of ITPN.</description><subject>Abdominal Surgery</subject><subject>Case Report</subject><subject>Colorectal Surgery</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Surgical Oncology</subject><issn>1865-7257</issn><issn>1865-7265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp9kM1KAzEUhYMotlYfwI1k6WY0N8kkmWUtVguFgug6pDMZO2X-TDKIb2_K1C5d3VxyzuGeD6FbIA9AiHz0QBlVCQGaEMZpAmdoCkqkiaQiPT-9UzlBV97vCRGUSHaJJlSAAkbpFG1WbXCmGPJgahyG7VB3vemrujbuB7e262vjG9yVOOws7k2bO2s8_q7CDvuuMaHK8dPbfImbIcSla6_RRWlqb2-Oc4Y-ls_vi9dkvXlZLebrJGech0RyCzmkLDU2z1RZqG3Ji0wYICWRgqlSFcZwkCwtOC9EJpURUmQl5ZAqQQ2bofsxt3fd12B90E3lcxvvjkcPXkP0yDTW5VEKozR3nffOlrp3VRP7aSD6wFGPHHXkqA8cNUTP3TF-2Da2ODn-wEUBHQU-frWf1ul9N7g2Vv4n9RdjFn1K</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>Urata, Takahiro</creator><creator>Naito, Yoshiki</creator><creator>Nagamine, Michiko</creator><creator>Izumi, Yoshihiro</creator><creator>Tonaki, Ginga</creator><creator>Iwasaki, Hajime</creator><creator>Sasaki, Akiko</creator><creator>Yamasaki, Akira</creator><creator>Minami, Nobuhiro</creator><creator>Yoshioka, Rituko</creator><creator>Kitada, Hideki</creator><creator>Takekuma, Yoshi</creator><creator>Yokomizo, Hiroshi</creator><creator>Fukuda, Seiji</creator><creator>Yamaguchi, Hiroshi</creator><creator>Kuboki, Yuko</creator><creator>Furukawa, Toru</creator><creator>Hifumi, Michio</creator><general>Springer Japan</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation</title><author>Urata, Takahiro ; 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We present a case of ITPN-associated microinvasive adenocarcinoma that developed in an asymptomatic 78-year-old patient. The tumor demonstrated all the clinical, radiological, and pathological characteristics of ITPN, but it differs from other reported cases of ITPN in molecular analysis, which revealed a somatic mutation in
BRAF
(c.1799T>A; p.V600E) but no mutation in
PIK3CA
. Post-operative recurrence was discovered 34 months after tumor resection with negative margins and a 6-month course of adjuvant chemotherapy. To the best of our knowledge, this is the first case of ITPN with
BRAF
mutation. This case suggests that an activation of RAS-mitogen-activated protein kinase signaling pathway may play a role in development of some of ITPNs. A possible mechanism of tumor recurrence in ITPN is also discussed. Further case series with molecular study are awaited to delineate the clinicopathological and molecular characteristics of ITPN.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>26181322</pmid><doi>10.1007/s12328-012-0342-1</doi><tpages>8</tpages></addata></record> |
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| subjects | Abdominal Surgery Case Report Colorectal Surgery Gastroenterology Hepatology Medicine Medicine & Public Health Surgical Oncology |
| title | Intraductal tubulopapillary neoplasm of the pancreas with somatic BRAF mutation |
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