Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’
R. J. Andersen, H. A. Luu, D. Z. X. Chen, C. F. B. Holmes, M. L. Kent, M. Le Blanc, F. J. R. Taylor and D. E. Williams. Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’. Toxicon 31, 1315–1323, 1993.—Evidence is presented that links microcystins to a severe liver d...
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| Veröffentlicht in: | Toxicon (Oxford) 1993-10, Vol.31 (10), p.1315-1323 |
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| container_title | Toxicon (Oxford) |
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| creator | Andersen, Raymond J. Luu, Hue A. Chen, Dawn Z.X. Holmes, Charles F.B. Kent, Michael L. Le Blanc, Mike Taylor, F.J.R.‘Max’ Williams, David E. |
| description | R. J. Andersen, H. A. Luu, D. Z. X. Chen, C. F. B. Holmes, M. L. Kent, M. Le Blanc, F. J. R. Taylor and
D. E. Williams. Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’.
Toxicon
31, 1315–1323, 1993.—Evidence is presented that links microcystins to a severe liver disease that occurs in Atlantic salmon that are netpen-reared in coastal British Columbia. Liquid chromatography-linked protein phosphatase bioassay analysis of extracts of liver tissue taken from Atlantic salmon afflicted with netpen liver disease showed the presence of an inhibitor of protein phosphatase that was chromatographically indistinguishable from microcystin-LR. Analysis of liver tissue from healthy control fish showed a complete absence of microcystin-LR. Intraperitoneal injection of microcystin-LR into healthy Atlantic salmon re-created the pathologic changes of netpen liver disease, including diffuse necrosis and hepatic megalocytosis. |
| doi_str_mv | 10.1016/0041-0101(93)90404-7 |
| format | Article |
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D. E. Williams. Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’.
Toxicon
31, 1315–1323, 1993.—Evidence is presented that links microcystins to a severe liver disease that occurs in Atlantic salmon that are netpen-reared in coastal British Columbia. Liquid chromatography-linked protein phosphatase bioassay analysis of extracts of liver tissue taken from Atlantic salmon afflicted with netpen liver disease showed the presence of an inhibitor of protein phosphatase that was chromatographically indistinguishable from microcystin-LR. Analysis of liver tissue from healthy control fish showed a complete absence of microcystin-LR. Intraperitoneal injection of microcystin-LR into healthy Atlantic salmon re-created the pathologic changes of netpen liver disease, including diffuse necrosis and hepatic megalocytosis.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/0041-0101(93)90404-7</identifier><identifier>PMID: 8303725</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Aquaculture ; bacteria ; Bacteriology ; Biological and medical sciences ; Chromatography, Liquid ; enzyme activity ; fish culture ; Fish Diseases - etiology ; Fish Diseases - pathology ; Fundamental and applied biological sciences. Psychology ; hepatotoxins ; histopathology ; inhibition ; liver ; liver diseases ; Liver Diseases - etiology ; Liver Diseases - pathology ; Liver Diseases - veterinary ; Marine ; Marine Toxins - analysis ; Microbiology ; Microcystins ; pathogenesis ; Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains ; Peptides, Cyclic - analysis ; Phosphoprotein Phosphatases - antagonists & inhibitors ; phosphoric monoester hydrolases ; Salmo salar ; Salmon - growth & development</subject><ispartof>Toxicon (Oxford), 1993-10, Vol.31 (10), p.1315-1323</ispartof><rights>1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-c69c8c8965c5dec09b8f4c79913ea4c1f95fdd046873d4d563677ed56ed917033</citedby><cites>FETCH-LOGICAL-c441t-c69c8c8965c5dec09b8f4c79913ea4c1f95fdd046873d4d563677ed56ed917033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-0101(93)90404-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3815266$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8303725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersen, Raymond J.</creatorcontrib><creatorcontrib>Luu, Hue A.</creatorcontrib><creatorcontrib>Chen, Dawn Z.X.</creatorcontrib><creatorcontrib>Holmes, Charles F.B.</creatorcontrib><creatorcontrib>Kent, Michael L.</creatorcontrib><creatorcontrib>Le Blanc, Mike</creatorcontrib><creatorcontrib>Taylor, F.J.R.‘Max’</creatorcontrib><creatorcontrib>Williams, David E.</creatorcontrib><title>Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>R. J. Andersen, H. A. Luu, D. Z. X. Chen, C. F. B. Holmes, M. L. Kent, M. Le Blanc, F. J. R. Taylor and
D. E. Williams. Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’.
Toxicon
31, 1315–1323, 1993.—Evidence is presented that links microcystins to a severe liver disease that occurs in Atlantic salmon that are netpen-reared in coastal British Columbia. Liquid chromatography-linked protein phosphatase bioassay analysis of extracts of liver tissue taken from Atlantic salmon afflicted with netpen liver disease showed the presence of an inhibitor of protein phosphatase that was chromatographically indistinguishable from microcystin-LR. Analysis of liver tissue from healthy control fish showed a complete absence of microcystin-LR. Intraperitoneal injection of microcystin-LR into healthy Atlantic salmon re-created the pathologic changes of netpen liver disease, including diffuse necrosis and hepatic megalocytosis.</description><subject>Animals</subject><subject>Aquaculture</subject><subject>bacteria</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid</subject><subject>enzyme activity</subject><subject>fish culture</subject><subject>Fish Diseases - etiology</subject><subject>Fish Diseases - pathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hepatotoxins</subject><subject>histopathology</subject><subject>inhibition</subject><subject>liver</subject><subject>liver diseases</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - pathology</subject><subject>Liver Diseases - veterinary</subject><subject>Marine</subject><subject>Marine Toxins - analysis</subject><subject>Microbiology</subject><subject>Microcystins</subject><subject>pathogenesis</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Peptides, Cyclic - analysis</subject><subject>Phosphoprotein Phosphatases - antagonists & inhibitors</subject><subject>phosphoric monoester hydrolases</subject><subject>Salmo salar</subject><subject>Salmon - growth & development</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uEzEQxy0EKmnhDUDsASE4LIxjrz8uSCgqH1IlDlCJm-XYs8Wwa6f2JlJvfQx4vT4J3ibKkdPYmt_8Nf6ZkGcU3lKg4h0Apy3U42vN3mjgwFv5gCyokrpltIOHZHFEHpPTUn4BAFNanJATxYDJZbcgP1Y_cQzODo2NvlmHNKSr-yvugsfosBlC_F2ayuTkbsoUYmmm1BQ7jCk2d7d_Ik4bjBXbYW58KGgL3t3-fUIe9XYo-PRQz8jlx_Pvq8_txddPX1YfLlrHOZ1aJ7RTri7Vuc6jA71WPXdSa8rQckd73fXeAxdKMs99J5iQEmtFr6kExs7Iq33uJqfrLZbJjKE4HAYbMW2LoUJLIZmqIN-D9SGlZOzNJofR5htDwcxCzWzLzLaMZuZeqJF17Pkhf7se0R-HDgZr_-Whb0v11mcbXShHjCnaLYWo2Is91ttk7FWuyOW3JVAGlCvOxRz0fk9gtbULmE1xYf4BHzK6yfgU_r_pPwmpnHo</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>Andersen, Raymond J.</creator><creator>Luu, Hue A.</creator><creator>Chen, Dawn Z.X.</creator><creator>Holmes, Charles F.B.</creator><creator>Kent, Michael L.</creator><creator>Le Blanc, Mike</creator><creator>Taylor, F.J.R.‘Max’</creator><creator>Williams, David E.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H97</scope><scope>H98</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>19931001</creationdate><title>Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’</title><author>Andersen, Raymond J. ; Luu, Hue A. ; Chen, Dawn Z.X. ; Holmes, Charles F.B. ; Kent, Michael L. ; Le Blanc, Mike ; Taylor, F.J.R.‘Max’ ; Williams, David E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-c69c8c8965c5dec09b8f4c79913ea4c1f95fdd046873d4d563677ed56ed917033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Animals</topic><topic>Aquaculture</topic><topic>bacteria</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Liquid</topic><topic>enzyme activity</topic><topic>fish culture</topic><topic>Fish Diseases - etiology</topic><topic>Fish Diseases - pathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hepatotoxins</topic><topic>histopathology</topic><topic>inhibition</topic><topic>liver</topic><topic>liver diseases</topic><topic>Liver Diseases - etiology</topic><topic>Liver Diseases - pathology</topic><topic>Liver Diseases - veterinary</topic><topic>Marine</topic><topic>Marine Toxins - analysis</topic><topic>Microbiology</topic><topic>Microcystins</topic><topic>pathogenesis</topic><topic>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</topic><topic>Peptides, Cyclic - analysis</topic><topic>Phosphoprotein Phosphatases - antagonists & inhibitors</topic><topic>phosphoric monoester hydrolases</topic><topic>Salmo salar</topic><topic>Salmon - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andersen, Raymond J.</creatorcontrib><creatorcontrib>Luu, Hue A.</creatorcontrib><creatorcontrib>Chen, Dawn Z.X.</creatorcontrib><creatorcontrib>Holmes, Charles F.B.</creatorcontrib><creatorcontrib>Kent, Michael L.</creatorcontrib><creatorcontrib>Le Blanc, Mike</creatorcontrib><creatorcontrib>Taylor, F.J.R.‘Max’</creatorcontrib><creatorcontrib>Williams, David E.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Aquaculture Abstracts</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersen, Raymond J.</au><au>Luu, Hue A.</au><au>Chen, Dawn Z.X.</au><au>Holmes, Charles F.B.</au><au>Kent, Michael L.</au><au>Le Blanc, Mike</au><au>Taylor, F.J.R.‘Max’</au><au>Williams, David E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>31</volume><issue>10</issue><spage>1315</spage><epage>1323</epage><pages>1315-1323</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>R. J. Andersen, H. A. Luu, D. Z. X. Chen, C. F. B. Holmes, M. L. Kent, M. Le Blanc, F. J. R. Taylor and
D. E. Williams. Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’.
Toxicon
31, 1315–1323, 1993.—Evidence is presented that links microcystins to a severe liver disease that occurs in Atlantic salmon that are netpen-reared in coastal British Columbia. Liquid chromatography-linked protein phosphatase bioassay analysis of extracts of liver tissue taken from Atlantic salmon afflicted with netpen liver disease showed the presence of an inhibitor of protein phosphatase that was chromatographically indistinguishable from microcystin-LR. Analysis of liver tissue from healthy control fish showed a complete absence of microcystin-LR. Intraperitoneal injection of microcystin-LR into healthy Atlantic salmon re-created the pathologic changes of netpen liver disease, including diffuse necrosis and hepatic megalocytosis.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>8303725</pmid><doi>10.1016/0041-0101(93)90404-7</doi><tpages>9</tpages></addata></record> |
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| ispartof | Toxicon (Oxford), 1993-10, Vol.31 (10), p.1315-1323 |
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| subjects | Animals Aquaculture bacteria Bacteriology Biological and medical sciences Chromatography, Liquid enzyme activity fish culture Fish Diseases - etiology Fish Diseases - pathology Fundamental and applied biological sciences. Psychology hepatotoxins histopathology inhibition liver liver diseases Liver Diseases - etiology Liver Diseases - pathology Liver Diseases - veterinary Marine Marine Toxins - analysis Microbiology Microcystins pathogenesis Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Peptides, Cyclic - analysis Phosphoprotein Phosphatases - antagonists & inhibitors phosphoric monoester hydrolases Salmo salar Salmon - growth & development |
| title | Chemical and biological evidence links microcystins to salmon ‘netpen liver disease’ |
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