A Single Amino Acid Exchange, Arg-45 to Ala, Generates an Epidermal Growth Factor (EGF) Mutant with High Affinity for the Chicken EGF Receptor (∗)

The finding that human epidermal growth factor (hEGF) and human transforming growth factor (hTGF) α bind with similar affinity to the human EGF receptor but differ in their affinity for the chicken EGF receptor was used as a model system to study ligand-receptor interaction of EGF receptor agonists....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 1995-09, Vol.270 (38), p.22337-22343
Hauptverfasser:	van de Poll, Monique L.M., Lenferink, Anne E.G., van Vugt, Marianne J.H., Jacobs, Jacqueline J.L., Janssen, Jannie W.H., Joldersma, Manon, van Zoelen, Everardus J.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding, Competitive Cell Division - drug effects Chickens Epidermal Growth Factor - chemistry Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology ErbB Receptors - metabolism Humans Mice Molecular Sequence Data Point Mutation Recombinant Proteins Sequence Alignment Sequence Homology, Amino Acid Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!