Protective role of γ/δ T cells and α/β T cells in tuberculosis
Tuberculosis is a chronic infectious disease which causes major health problems globally. Although acquired resistance crucially depends on α/β lymphocytes, circumstantial evidence suggests that, in addition, γ/δ T lymphocytes contribute to protection against tuberculosis. We have studied Mycobacter...
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| Veröffentlicht in: | European journal of immunology 1995-10, Vol.25 (10), p.2877-2881 |
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| creator | Ladel, Christoph H. Blum, Carmen Dreher, Anja Reifenberg, Kurt Kaufmann, Stefan H. E. |
| description | Tuberculosis is a chronic infectious disease which causes major health problems globally. Although acquired resistance crucially depends on α/β lymphocytes, circumstantial evidence suggests that, in addition, γ/δ T lymphocytes contribute to protection against tuberculosis. We have studied Mycobacterium tuberculosis infection in TcR‐δ‐/‐ or TcR‐β‐/‐ gene deletion mutants which completely lack γ/δ T cells or α/β T cells, respectively. Low inocula of M. tuberculosis led to death of TcR‐β‐/‐ mice and transient disease exacerbation in TcR‐δ‐/‐ mutants. Infection with higher inocula caused rapid death of TcR‐δ‐/‐ mice. The development of and bacterial containment in granulomatous lesions was markedly impaired in TcR‐β‐/‐, and less severly affected in TcR‐δ‐/‐ mutants. Mycobacteria‐induced IFN‐γ production by spleen cells in vitro was almost abolished in TcR‐β‐/‐ and virtually unaffected in TcR‐δ‐/‐ mice. Our data confirm the crucial role of α/β T cells in protection against established tuberculosis and formally prove a protective role of γ/δ T cells in early tuberculosis. |
| doi_str_mv | 10.1002/eji.1830251025 |
| format | Article |
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E.</creator><creatorcontrib>Ladel, Christoph H. ; Blum, Carmen ; Dreher, Anja ; Reifenberg, Kurt ; Kaufmann, Stefan H. E.</creatorcontrib><description>Tuberculosis is a chronic infectious disease which causes major health problems globally. Although acquired resistance crucially depends on α/β lymphocytes, circumstantial evidence suggests that, in addition, γ/δ T lymphocytes contribute to protection against tuberculosis. We have studied Mycobacterium tuberculosis infection in TcR‐δ‐/‐ or TcR‐β‐/‐ gene deletion mutants which completely lack γ/δ T cells or α/β T cells, respectively. Low inocula of M. tuberculosis led to death of TcR‐β‐/‐ mice and transient disease exacerbation in TcR‐δ‐/‐ mutants. Infection with higher inocula caused rapid death of TcR‐δ‐/‐ mice. The development of and bacterial containment in granulomatous lesions was markedly impaired in TcR‐β‐/‐, and less severly affected in TcR‐δ‐/‐ mutants. Mycobacteria‐induced IFN‐γ production by spleen cells in vitro was almost abolished in TcR‐β‐/‐ and virtually unaffected in TcR‐δ‐/‐ mice. Our data confirm the crucial role of α/β T cells in protection against established tuberculosis and formally prove a protective role of γ/δ T cells in early tuberculosis.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830251025</identifier><identifier>PMID: 7589086</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Animals ; Cytokine production ; Granuloma formation ; Immunologic Deficiency Syndromes - complications ; Immunologic Deficiency Syndromes - genetics ; Interferon-gamma - biosynthesis ; Lethal Dose 50 ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mycobacterium tuberculosis ; Receptors, Antigen, T-Cell, alpha-beta - genetics ; Receptors, Antigen, T-Cell, gamma-delta - genetics ; Specific Pathogen-Free Organisms ; Spleen - immunology ; Spleen - pathology ; T cell receptor‐deficient mice ; T-Lymphocyte Subsets - chemistry ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - metabolism ; Tuberculoma - immunology ; Tuberculoma - pathology ; Tuberculosis ; Tuberculosis - complications ; Tuberculosis - immunology</subject><ispartof>European journal of immunology, 1995-10, Vol.25 (10), p.2877-2881</ispartof><rights>Copyright © 1995 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3715-6cf1d65c4df0b16b1080ec9abbbf4c5070468b3e0e8fa5519a659aee01f592a43</citedby><cites>FETCH-LOGICAL-c3715-6cf1d65c4df0b16b1080ec9abbbf4c5070468b3e0e8fa5519a659aee01f592a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830251025$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830251025$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7589086$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ladel, Christoph H.</creatorcontrib><creatorcontrib>Blum, Carmen</creatorcontrib><creatorcontrib>Dreher, Anja</creatorcontrib><creatorcontrib>Reifenberg, Kurt</creatorcontrib><creatorcontrib>Kaufmann, Stefan H. E.</creatorcontrib><title>Protective role of γ/δ T cells and α/β T cells in tuberculosis</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>Tuberculosis is a chronic infectious disease which causes major health problems globally. Although acquired resistance crucially depends on α/β lymphocytes, circumstantial evidence suggests that, in addition, γ/δ T lymphocytes contribute to protection against tuberculosis. We have studied Mycobacterium tuberculosis infection in TcR‐δ‐/‐ or TcR‐β‐/‐ gene deletion mutants which completely lack γ/δ T cells or α/β T cells, respectively. Low inocula of M. tuberculosis led to death of TcR‐β‐/‐ mice and transient disease exacerbation in TcR‐δ‐/‐ mutants. Infection with higher inocula caused rapid death of TcR‐δ‐/‐ mice. The development of and bacterial containment in granulomatous lesions was markedly impaired in TcR‐β‐/‐, and less severly affected in TcR‐δ‐/‐ mutants. Mycobacteria‐induced IFN‐γ production by spleen cells in vitro was almost abolished in TcR‐β‐/‐ and virtually unaffected in TcR‐δ‐/‐ mice. Our data confirm the crucial role of α/β T cells in protection against established tuberculosis and formally prove a protective role of γ/δ T cells in early tuberculosis.</description><subject>Animals</subject><subject>Cytokine production</subject><subject>Granuloma formation</subject><subject>Immunologic Deficiency Syndromes - complications</subject><subject>Immunologic Deficiency Syndromes - genetics</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Lethal Dose 50</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Mycobacterium tuberculosis</subject><subject>Receptors, Antigen, T-Cell, alpha-beta - genetics</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - genetics</subject><subject>Specific Pathogen-Free Organisms</subject><subject>Spleen - immunology</subject><subject>Spleen - pathology</subject><subject>T cell receptor‐deficient mice</subject><subject>T-Lymphocyte Subsets - chemistry</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - metabolism</subject><subject>Tuberculoma - immunology</subject><subject>Tuberculoma - pathology</subject><subject>Tuberculosis</subject><subject>Tuberculosis - complications</subject><subject>Tuberculosis - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9Lw0AQxRdRaq1evQk5eUs7k2ST7FFL1UpBD_W87G5mISVtajZR-rH88znymUxpqd48DAPz3vx4PMYuEYYIEIxokQ8xDSHg2M0R6yMP0I8wwmPWB8DID0QKp-zMuQUAiJiLHuslPBWQxn12-1yVNZk6fyOvKgvySuu1X6P225t7horCeWqVee3HqP08XPKVVzeaKtMUpcvdOTuxqnB0sd8D9nI3mY8f_NnT_XR8M_NNmCD3Y2Mxi7mJMgsaY42QAhmhtNY2MhwSiOJUhwSUWsU5CtVFVUSAlotAReGAXe-466p8bcjVcpm7bSK1orJxEmORBFGYdsbhzmiq0rmKrFxX-VJVG4kgt6XJrjT5W1r3cLUnN3pJ2cG-b6nTxU5_zwva_EOTk8fpH_YPybd51Q</recordid><startdate>199510</startdate><enddate>199510</enddate><creator>Ladel, Christoph H.</creator><creator>Blum, Carmen</creator><creator>Dreher, Anja</creator><creator>Reifenberg, Kurt</creator><creator>Kaufmann, Stefan H. E.</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>199510</creationdate><title>Protective role of γ/δ T cells and α/β T cells in tuberculosis</title><author>Ladel, Christoph H. ; Blum, Carmen ; Dreher, Anja ; Reifenberg, Kurt ; Kaufmann, Stefan H. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3715-6cf1d65c4df0b16b1080ec9abbbf4c5070468b3e0e8fa5519a659aee01f592a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Cytokine production</topic><topic>Granuloma formation</topic><topic>Immunologic Deficiency Syndromes - complications</topic><topic>Immunologic Deficiency Syndromes - genetics</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Lethal Dose 50</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Mycobacterium tuberculosis</topic><topic>Receptors, Antigen, T-Cell, alpha-beta - genetics</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - genetics</topic><topic>Specific Pathogen-Free Organisms</topic><topic>Spleen - immunology</topic><topic>Spleen - pathology</topic><topic>T cell receptor‐deficient mice</topic><topic>T-Lymphocyte Subsets - chemistry</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - metabolism</topic><topic>Tuberculoma - immunology</topic><topic>Tuberculoma - pathology</topic><topic>Tuberculosis</topic><topic>Tuberculosis - complications</topic><topic>Tuberculosis - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ladel, Christoph H.</creatorcontrib><creatorcontrib>Blum, Carmen</creatorcontrib><creatorcontrib>Dreher, Anja</creatorcontrib><creatorcontrib>Reifenberg, Kurt</creatorcontrib><creatorcontrib>Kaufmann, Stefan H. 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E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective role of γ/δ T cells and α/β T cells in tuberculosis</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1995-10</date><risdate>1995</risdate><volume>25</volume><issue>10</issue><spage>2877</spage><epage>2881</epage><pages>2877-2881</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>Tuberculosis is a chronic infectious disease which causes major health problems globally. Although acquired resistance crucially depends on α/β lymphocytes, circumstantial evidence suggests that, in addition, γ/δ T lymphocytes contribute to protection against tuberculosis. We have studied Mycobacterium tuberculosis infection in TcR‐δ‐/‐ or TcR‐β‐/‐ gene deletion mutants which completely lack γ/δ T cells or α/β T cells, respectively. Low inocula of M. tuberculosis led to death of TcR‐β‐/‐ mice and transient disease exacerbation in TcR‐δ‐/‐ mutants. Infection with higher inocula caused rapid death of TcR‐δ‐/‐ mice. The development of and bacterial containment in granulomatous lesions was markedly impaired in TcR‐β‐/‐, and less severly affected in TcR‐δ‐/‐ mutants. Mycobacteria‐induced IFN‐γ production by spleen cells in vitro was almost abolished in TcR‐β‐/‐ and virtually unaffected in TcR‐δ‐/‐ mice. Our data confirm the crucial role of α/β T cells in protection against established tuberculosis and formally prove a protective role of γ/δ T cells in early tuberculosis.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>7589086</pmid><doi>10.1002/eji.1830251025</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Cytokine production Granuloma formation Immunologic Deficiency Syndromes - complications Immunologic Deficiency Syndromes - genetics Interferon-gamma - biosynthesis Lethal Dose 50 Mice Mice, Inbred C57BL Mice, Knockout Mycobacterium tuberculosis Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, gamma-delta - genetics Specific Pathogen-Free Organisms Spleen - immunology Spleen - pathology T cell receptor‐deficient mice T-Lymphocyte Subsets - chemistry T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tuberculoma - immunology Tuberculoma - pathology Tuberculosis Tuberculosis - complications Tuberculosis - immunology |
| title | Protective role of γ/δ T cells and α/β T cells in tuberculosis |
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