A PBPK model describing a xenobiotic with a short PK event scale

Physiologically-based pharmacokinetic (PBPK) modeling has been widely used in human risk assessment and in early drug development to predict human PK from in vitro and/or in vivo animal data. Recently, the application of PBPK modeling has been extended to the evaluation of drug–drug interactions. Fo...

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Veröffentlicht in:	Journal of pharmacokinetics and pharmacodynamics 2015-08, Vol.42 (4), p.409-416
Hauptverfasser:	Wang, Xiaofeng, Davies, Brian E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biotransformation Coronary Circulation - physiology Humans Lung - metabolism Lung - physiology Metabolic Clearance Rate Models, Biological Original Paper Pharmacology/Toxicology Pharmacy Pulmonary Circulation - physiology Time Factors Veterinary Medicine/Veterinary Science Xenobiotics - blood Xenobiotics - pharmacokinetics
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