The tumour necrosis factor-α 308G>A genetic polymorphism may contribute to the pathogenesis of acne: a meta-analysis
Summary Background Tumour necrosis factor (TNF)‐α is considered to play a central role in the pathogenesis of acne. Aim To estimate the association between the TNF‐α 308G>A polymorphism and the pathogenesis of acne. Methods A literature search of the PubMed and CNKI databases from inception to De...
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| Veröffentlicht in: | Clinical and experimental dermatology 2015-08, Vol.40 (6), p.682-687 |
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| container_title | Clinical and experimental dermatology |
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| creator | Li, L. Wu, Y. Cai, Y. F. Geng, L. Gao, X. H. Chen, H. D. |
| description | Summary
Background
Tumour necrosis factor (TNF)‐α is considered to play a central role in the pathogenesis of acne.
Aim
To estimate the association between the TNF‐α 308G>A polymorphism and the pathogenesis of acne.
Methods
A literature search of the PubMed and CNKI databases from inception to December 2013 was conducted. Meta‐analyses were performed, and the OR and 95% CI calculated. The strength of association was assessed under five genetic models: allele (A vs. G), dominant (AA+AG vs. GG), recessive (AA vs. GG+AG), homozygous (AA vs. GG), and heterozygous (AA vs. AG).
Results
Seven case–control studies were included, with a total of 987 patients with acne and 1078 healthy controls. The meta‐analysis result showed a significant association between TNF‐α 308G>A and the pathogenesis of acne under the recessive (OR = 3.13, 95% CI 1.67–5.86, P |
| doi_str_mv | 10.1111/ced.12660 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1697220518</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1697220518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3480-ecfd96fbf47d3c52074ebe7fb8a3bf9da04cc5235c1feb03db836708e18d91743</originalsourceid><addsrcrecordid>eNp1kMFO3DAQhq2qVdkCh74A8rEcwtpxEiccKq2W3aXSCpAA7dFynHE3kMTBdtTmsfoifaZ6WbY3fBlr5ptPmh-hr5Rc0PCmCqoLGmcZ-YAmlGVpFMeMfEQTwgiPsoLlR-iLc0-EUEZ5-hkdxWkRPjyeoOFhC9gPrRks7kBZ42qHtVTe2OjvH8xIvvo-wz-hA18r3JtmbI3tt7VrcStHrEznbV0OPkgM9sHVS781O34nMhpL1cEllrgFLyPZyWYMgxP0ScvGwelbPUaPy8XD_Dpa365-zGfrSLEkJxEoXRWZLnXCK6bSmPAESuC6zCUrdVFJkqjQZqmiGkrCqjJnGSc50LwKBybsGH3be3trXgZwXrS1U9A0sgMzOEGzgscxSWke0PM9usvAWdCit3Ur7SgoEbuURUhZvKYc2LM37VC2oXsgD7EGYLoHftUNjO-bxHxxdVBG-43aefj9f0PaZ5FxxlOxuVkJxjfL-_XyTszZPwyvl2o</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1697220518</pqid></control><display><type>article</type><title>The tumour necrosis factor-α 308G>A genetic polymorphism may contribute to the pathogenesis of acne: a meta-analysis</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Li, L. ; Wu, Y. ; Cai, Y. F. ; Geng, L. ; Gao, X. H. ; Chen, H. D.</creator><creatorcontrib>Li, L. ; Wu, Y. ; Cai, Y. F. ; Geng, L. ; Gao, X. H. ; Chen, H. D.</creatorcontrib><description>Summary
Background
Tumour necrosis factor (TNF)‐α is considered to play a central role in the pathogenesis of acne.
Aim
To estimate the association between the TNF‐α 308G>A polymorphism and the pathogenesis of acne.
Methods
A literature search of the PubMed and CNKI databases from inception to December 2013 was conducted. Meta‐analyses were performed, and the OR and 95% CI calculated. The strength of association was assessed under five genetic models: allele (A vs. G), dominant (AA+AG vs. GG), recessive (AA vs. GG+AG), homozygous (AA vs. GG), and heterozygous (AA vs. AG).
Results
Seven case–control studies were included, with a total of 987 patients with acne and 1078 healthy controls. The meta‐analysis result showed a significant association between TNF‐α 308G>A and the pathogenesis of acne under the recessive (OR = 3.13, 95% CI 1.67–5.86, P < 0.001), homozygous (OR = 3.03, 95% CI 1.63–5.63, P < 0.001) and heterozygous (OR = 3.16, 95% CI 1.61–6.20, P < 0.001) models. The subgroup analysis showed a significant association with male sex (recessive: OR = 3.77, 95% CI 1.26–11.25, P = 0.02, homozygous: OR = 3.25, 95% CI 1.03–10.22, P = 0.04) and severe acne (recessive: OR = 4.62, 95% CI 1.73–12.34, P < 0.01; homozygous: OR = 3.41, 95% CI 1.18–9.89, P = 0.02).
Conclusion
Our findings indicate that genotype AA of TNF‐α 308G>A may contribute to the pathogenesis of acne. Thus, detection of the TNF‐α 308G>A polymorphism may be a promising biomarker for the early detection of acne.
Click here for the corresponding questions to this CME article.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/ced.12660</identifier><identifier>PMID: 25917572</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Acne Vulgaris - genetics ; Alleles ; Case-Control Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Risk Factors ; Tumor Necrosis Factor-alpha - genetics</subject><ispartof>Clinical and experimental dermatology, 2015-08, Vol.40 (6), p.682-687</ispartof><rights>2015 British Association of Dermatologists</rights><rights>2015 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3480-ecfd96fbf47d3c52074ebe7fb8a3bf9da04cc5235c1feb03db836708e18d91743</citedby><cites>FETCH-LOGICAL-c3480-ecfd96fbf47d3c52074ebe7fb8a3bf9da04cc5235c1feb03db836708e18d91743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25917572$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, L.</creatorcontrib><creatorcontrib>Wu, Y.</creatorcontrib><creatorcontrib>Cai, Y. F.</creatorcontrib><creatorcontrib>Geng, L.</creatorcontrib><creatorcontrib>Gao, X. H.</creatorcontrib><creatorcontrib>Chen, H. D.</creatorcontrib><title>The tumour necrosis factor-α 308G>A genetic polymorphism may contribute to the pathogenesis of acne: a meta-analysis</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Background
Tumour necrosis factor (TNF)‐α is considered to play a central role in the pathogenesis of acne.
Aim
To estimate the association between the TNF‐α 308G>A polymorphism and the pathogenesis of acne.
Methods
A literature search of the PubMed and CNKI databases from inception to December 2013 was conducted. Meta‐analyses were performed, and the OR and 95% CI calculated. The strength of association was assessed under five genetic models: allele (A vs. G), dominant (AA+AG vs. GG), recessive (AA vs. GG+AG), homozygous (AA vs. GG), and heterozygous (AA vs. AG).
Results
Seven case–control studies were included, with a total of 987 patients with acne and 1078 healthy controls. The meta‐analysis result showed a significant association between TNF‐α 308G>A and the pathogenesis of acne under the recessive (OR = 3.13, 95% CI 1.67–5.86, P < 0.001), homozygous (OR = 3.03, 95% CI 1.63–5.63, P < 0.001) and heterozygous (OR = 3.16, 95% CI 1.61–6.20, P < 0.001) models. The subgroup analysis showed a significant association with male sex (recessive: OR = 3.77, 95% CI 1.26–11.25, P = 0.02, homozygous: OR = 3.25, 95% CI 1.03–10.22, P = 0.04) and severe acne (recessive: OR = 4.62, 95% CI 1.73–12.34, P < 0.01; homozygous: OR = 3.41, 95% CI 1.18–9.89, P = 0.02).
Conclusion
Our findings indicate that genotype AA of TNF‐α 308G>A may contribute to the pathogenesis of acne. Thus, detection of the TNF‐α 308G>A polymorphism may be a promising biomarker for the early detection of acne.
Click here for the corresponding questions to this CME article.</description><subject>Acne Vulgaris - genetics</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFO3DAQhq2qVdkCh74A8rEcwtpxEiccKq2W3aXSCpAA7dFynHE3kMTBdtTmsfoifaZ6WbY3fBlr5ptPmh-hr5Rc0PCmCqoLGmcZ-YAmlGVpFMeMfEQTwgiPsoLlR-iLc0-EUEZ5-hkdxWkRPjyeoOFhC9gPrRks7kBZ42qHtVTe2OjvH8xIvvo-wz-hA18r3JtmbI3tt7VrcStHrEznbV0OPkgM9sHVS781O34nMhpL1cEllrgFLyPZyWYMgxP0ScvGwelbPUaPy8XD_Dpa365-zGfrSLEkJxEoXRWZLnXCK6bSmPAESuC6zCUrdVFJkqjQZqmiGkrCqjJnGSc50LwKBybsGH3be3trXgZwXrS1U9A0sgMzOEGzgscxSWke0PM9usvAWdCit3Ur7SgoEbuURUhZvKYc2LM37VC2oXsgD7EGYLoHftUNjO-bxHxxdVBG-43aefj9f0PaZ5FxxlOxuVkJxjfL-_XyTszZPwyvl2o</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Li, L.</creator><creator>Wu, Y.</creator><creator>Cai, Y. F.</creator><creator>Geng, L.</creator><creator>Gao, X. H.</creator><creator>Chen, H. D.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>The tumour necrosis factor-α 308G>A genetic polymorphism may contribute to the pathogenesis of acne: a meta-analysis</title><author>Li, L. ; Wu, Y. ; Cai, Y. F. ; Geng, L. ; Gao, X. H. ; Chen, H. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3480-ecfd96fbf47d3c52074ebe7fb8a3bf9da04cc5235c1feb03db836708e18d91743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acne Vulgaris - genetics</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, L.</creatorcontrib><creatorcontrib>Wu, Y.</creatorcontrib><creatorcontrib>Cai, Y. F.</creatorcontrib><creatorcontrib>Geng, L.</creatorcontrib><creatorcontrib>Gao, X. H.</creatorcontrib><creatorcontrib>Chen, H. D.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, L.</au><au>Wu, Y.</au><au>Cai, Y. F.</au><au>Geng, L.</au><au>Gao, X. H.</au><au>Chen, H. D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The tumour necrosis factor-α 308G>A genetic polymorphism may contribute to the pathogenesis of acne: a meta-analysis</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2015-08</date><risdate>2015</risdate><volume>40</volume><issue>6</issue><spage>682</spage><epage>687</epage><pages>682-687</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><abstract>Summary
Background
Tumour necrosis factor (TNF)‐α is considered to play a central role in the pathogenesis of acne.
Aim
To estimate the association between the TNF‐α 308G>A polymorphism and the pathogenesis of acne.
Methods
A literature search of the PubMed and CNKI databases from inception to December 2013 was conducted. Meta‐analyses were performed, and the OR and 95% CI calculated. The strength of association was assessed under five genetic models: allele (A vs. G), dominant (AA+AG vs. GG), recessive (AA vs. GG+AG), homozygous (AA vs. GG), and heterozygous (AA vs. AG).
Results
Seven case–control studies were included, with a total of 987 patients with acne and 1078 healthy controls. The meta‐analysis result showed a significant association between TNF‐α 308G>A and the pathogenesis of acne under the recessive (OR = 3.13, 95% CI 1.67–5.86, P < 0.001), homozygous (OR = 3.03, 95% CI 1.63–5.63, P < 0.001) and heterozygous (OR = 3.16, 95% CI 1.61–6.20, P < 0.001) models. The subgroup analysis showed a significant association with male sex (recessive: OR = 3.77, 95% CI 1.26–11.25, P = 0.02, homozygous: OR = 3.25, 95% CI 1.03–10.22, P = 0.04) and severe acne (recessive: OR = 4.62, 95% CI 1.73–12.34, P < 0.01; homozygous: OR = 3.41, 95% CI 1.18–9.89, P = 0.02).
Conclusion
Our findings indicate that genotype AA of TNF‐α 308G>A may contribute to the pathogenesis of acne. Thus, detection of the TNF‐α 308G>A polymorphism may be a promising biomarker for the early detection of acne.
Click here for the corresponding questions to this CME article.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>25917572</pmid><doi>10.1111/ced.12660</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical and experimental dermatology, 2015-08, Vol.40 (6), p.682-687 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Acne Vulgaris - genetics Alleles Case-Control Studies Genetic Predisposition to Disease Genotype Humans Polymorphism, Single Nucleotide Risk Factors Tumor Necrosis Factor-alpha - genetics |
| title | The tumour necrosis factor-α 308G>A genetic polymorphism may contribute to the pathogenesis of acne: a meta-analysis |
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