Effect of Sex Differences on Brain Mitochondrial Function and Its Suppression by Ovariectomy and in Aged Mice

Sex steroids regulate brain function in both normal and pathological states. Mitochondria are an essential target of steroids, as demonstrated by the experimental administration of 17β-estradiol or progesterone (PROG) to ovariectomized female rodents, but the influence of endogenous sex steroids rem...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2015-08, Vol.156 (8), p.2893-2904
Hauptverfasser:	Gaignard, Pauline, Savouroux, Stéphane, Liere, Philippe, Pianos, Antoine, Thérond, Patrice, Schumacher, Michael, Slama, Abdelhamid, Guennoun, Rachida
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Adenine Aging - physiology Animals Brain Brain - drug effects Brain - metabolism Brain - ultrastructure Cell Respiration - drug effects Estradiol - pharmacology Estrus cycle Female Females Flavin-Adenine Dinucleotide - analogs & derivatives Flavin-Adenine Dinucleotide - metabolism Gender differences Gonadectomy Male Males Mice Mice, Inbred C57BL Mitochondria Mitochondria - drug effects Mitochondria - physiology NAD NAD - metabolism Nicotinamide Nicotinamide adenine dinucleotide Oophorectomy Orchidectomy Ovariectomy Oxidative phosphorylation Oxidative stress Oxidative Stress - physiology Phosphorylation Pregnenolone Progesterone Pyruvate dehydrogenase (lipoamide) Pyruvic acid Sex Characteristics Sex differences Sex hormones Steroids Young adults
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