The conformational states of talin autoinhibition complex and its activation under forces

Talin is an integrin-binding protein located at focal adhesion site and serves as both an adapter and a force transmitter. Its in- tegrin binding activity is regulated by the intramolecular autoinhibition interaction between its F3 and RS domains. Here, we used atomic force microscopy to measure the...

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Veröffentlicht in:	Science China. Life sciences 2015-07, Vol.58 (7), p.694-703
Hauptverfasser:	Zeng, Yan, Zhang, Yong, Song, XianQiang, Ji, QingHua, Ye, Sheng, Zhang, RongGuang, Lou, JiZhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical and Life Sciences Life Sciences Molecular Dynamics Simulation Protein Conformation Research Paper Talin - antagonists & inhibitors Talin - chemistry 分子动力学 力传感器 原子力显微镜 塔 复杂受力 活化 稳定构象 结合蛋白
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