Enhanced astroglial Ca2+ signaling increases excitatory synaptic strength in the epileptic brain

The fine‐tuning of synaptic transmission by astrocyte signaling is crucial to CNS physiology. However, how exactly astroglial excitability and gliotransmission are affected in several neuropathologies, including epilepsy, remains unclear. Here, using a chronic model of temporal lobe epilepsy (TLE) i...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Glia 2015-09, Vol.63 (9), p.1507-1521
Hauptverfasser:	Álvarez-Ferradas, Carla, Morales, Juan Carlos, Wellmann, Mario, Nualart, Francisco, Roncagliolo, Manuel, Fuenzalida, Marco, Bonansco, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocyte Astrocytes - drug effects Astrocytes - pathology Astrocytes - physiology Brain - drug effects Brain - pathology Brain - physiopathology Calcium - metabolism Cations, Divalent - metabolism Chronic Disease Disease Models, Animal Epilepsy Epilepsy, Temporal Lobe - drug therapy Epilepsy, Temporal Lobe - pathology Epilepsy, Temporal Lobe - physiopathology gliotransmission hippocampus Immunohistochemistry kindling Kindling, Neurologic Male neurotransmission Patch-Clamp Techniques Rats, Sprague-Dawley Receptor, Metabotropic Glutamate 5 - metabolism Receptors, Purinergic P2Y1 - metabolism Synapses - drug effects Synapses - pathology Synapses - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology Tissue Culture Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!