Non‐16/18 high‐risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL
BACKGROUND The current management strategy for women with low‐grade squamous intraepithelial lesions (LSILs) is inefficient and expensive because of the inability to identify patients at high risk for disease progression. The current study was designed to determine the genotypic patterns of human pa...
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| Veröffentlicht in: | Cancer cytopathology 2015-07, Vol.123 (7), p.435-442 |
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| creator | Lyons, Yasmin A. Kamat, Aparna A. Zhou, Haijun Mody, Dina R. Schwartz, Mary R. Hobday, Christopher Ge, Yimin |
| description | BACKGROUND
The current management strategy for women with low‐grade squamous intraepithelial lesions (LSILs) is inefficient and expensive because of the inability to identify patients at high risk for disease progression. The current study was designed to determine the genotypic patterns of human papillomavirus (HPV) associated with the persistence and progression of cervical lesions in women with an initial interpretation of LSIL.
METHODS
One hundred sixty‐seven women with LSIL on Papanicolaou tests collected between December 1, 2009 and March 30, 2011 were studied. HPV DNA was extracted from residual SurePath specimens, genotypes were determined with a DNA microarray containing 40 HPV genotype probes, and microarray data were confirmed by sequencing. Follow‐up Papanicolaou tests and/or biopsies were performed within a 20‐ to 46‐month period after the initial diagnosis.
RESULTS
Ninety‐seven of the 167 cases with follow‐up results were included in the study. Compared with the women with a regressed cervical lesion, those with a persistent cervical lesion (PCL) were significantly more commonly infected with high‐risk human papillomavirus (HR‐HPV) genotypes (P |
| doi_str_mv | 10.1002/cncy.21549 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1697212551</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1697212551</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3939-8f4d44ee92da43397894ff8ef4a2f76152d2dc09a253eca6942695323cb9251f3</originalsourceid><addsrcrecordid>eNp9kctKAzEUhoMotl42PoAE3IhQm-t0spTiDYoKXtDVEDMnNnWaqcmU0p34BD6jT2Jq1YULNzk5ycfH4fwI7VBySAlhXePN_JBRKdQKalPFRSfLeL76e2f3LbQR44gQmvcYXUctJhXhhMo2eruo_cfrO826NMdD9zRMTXDxGZ9d3WHnLZjG1R5PApTONBGXLoKOgCcQoosNeANY-zIB9VOAGBew83hWjyGdrhmm3_TgGqerVBsISdXoL2lt8eD6fLCF1qyuImx_1010e3J80z_rDC5Pz_tHg47hiqtObkUpBIBipRacq16uhLU5WKGZ7WVUspKVhijNJAejMyVYpiRn3DwqJqnlm2h_6U2zvkwhNsXYRQNVpT3U01jQTKXtMClpQvf-oKN6GnyabkFlhHMpe4k6WFIm1DEGsMUkuLEO84KSYpFMsUim-EomwbvfyunjGMpf9CeKBNAlMHMVzP9RFf2L_sNS-gnHrZqe</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1696033557</pqid></control><display><type>article</type><title>Non‐16/18 high‐risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><creator>Lyons, Yasmin A. ; Kamat, Aparna A. ; Zhou, Haijun ; Mody, Dina R. ; Schwartz, Mary R. ; Hobday, Christopher ; Ge, Yimin</creator><creatorcontrib>Lyons, Yasmin A. ; Kamat, Aparna A. ; Zhou, Haijun ; Mody, Dina R. ; Schwartz, Mary R. ; Hobday, Christopher ; Ge, Yimin</creatorcontrib><description>BACKGROUND
The current management strategy for women with low‐grade squamous intraepithelial lesions (LSILs) is inefficient and expensive because of the inability to identify patients at high risk for disease progression. The current study was designed to determine the genotypic patterns of human papillomavirus (HPV) associated with the persistence and progression of cervical lesions in women with an initial interpretation of LSIL.
METHODS
One hundred sixty‐seven women with LSIL on Papanicolaou tests collected between December 1, 2009 and March 30, 2011 were studied. HPV DNA was extracted from residual SurePath specimens, genotypes were determined with a DNA microarray containing 40 HPV genotype probes, and microarray data were confirmed by sequencing. Follow‐up Papanicolaou tests and/or biopsies were performed within a 20‐ to 46‐month period after the initial diagnosis.
RESULTS
Ninety‐seven of the 167 cases with follow‐up results were included in the study. Compared with the women with a regressed cervical lesion, those with a persistent cervical lesion (PCL) were significantly more commonly infected with high‐risk human papillomavirus (HR‐HPV) genotypes (P < .01) and particularly with non‐16/18 HR‐HPV genotypes (P < .05). The PCL group also had a significantly higher average number of HR‐HPV genotypes and non‐16/18 HPV genotypes per specimen (P < .01). Infection with HPV‐16/18 genotypes was not significantly associated with the persistence or progression of cervical lesions.
CONCLUSIONS
Infection with non‐16/18 HR‐HPV genotypes but not with HPV‐16/18 genotypes was a strong predictor of the persistence and progression of cervical disease upon follow‐up. Genotyping solely for HPV‐16/18 would miss the majority of patients with LSIL who progress to high‐grade squamous intraepithelial lesions. Pooled HR‐HPV tests provide a better predictive value than HPV‐16/18 genotyping alone in guiding the clinical management of patients with LSIL. Cancer (Cancer Cytopathol) 2015;123:435‐42. © 2015 American Cancer Society.
Non‐16/18 high‐risk human papillomavirus genotypes strongly predict persistent cervical lesions and progression to high‐grade lesions in women with an initial cytology interpretation of a low‐grade squamous intraepithelial lesion.</description><identifier>ISSN: 1934-662X</identifier><identifier>EISSN: 1934-6638</identifier><identifier>DOI: 10.1002/cncy.21549</identifier><identifier>PMID: 25903015</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age Factors ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Cervical Intraepithelial Neoplasia - genetics ; Cervical Intraepithelial Neoplasia - pathology ; Cervical Intraepithelial Neoplasia - physiopathology ; China - epidemiology ; Chronic Disease ; Cohort Studies ; Disease Progression ; DNA, Viral - genetics ; Female ; Genotype ; human papillomavirus (HPV) ; Human papillomavirus 16 - genetics ; Human papillomavirus 18 - genetics ; human papillomavirus genotyping ; Humans ; low‐grade squamous intraepithelial lesion ; Middle Aged ; Neoplasm Invasiveness - pathology ; non‐16/18 high‐risk human papillomavirus genotypes ; Papanicolaou Test ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - genetics ; Papillomavirus Infections - pathology ; persistent cervical dysplasia ; Predictive Value of Tests ; Prevalence ; progression of cervical disease ; Retrospective Studies ; Risk Assessment ; Vaginal Smears ; Young Adult</subject><ispartof>Cancer cytopathology, 2015-07, Vol.123 (7), p.435-442</ispartof><rights>2015 American Cancer Society</rights><rights>2015 American Cancer Society.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3939-8f4d44ee92da43397894ff8ef4a2f76152d2dc09a253eca6942695323cb9251f3</citedby><cites>FETCH-LOGICAL-c3939-8f4d44ee92da43397894ff8ef4a2f76152d2dc09a253eca6942695323cb9251f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncy.21549$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncy.21549$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25903015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lyons, Yasmin A.</creatorcontrib><creatorcontrib>Kamat, Aparna A.</creatorcontrib><creatorcontrib>Zhou, Haijun</creatorcontrib><creatorcontrib>Mody, Dina R.</creatorcontrib><creatorcontrib>Schwartz, Mary R.</creatorcontrib><creatorcontrib>Hobday, Christopher</creatorcontrib><creatorcontrib>Ge, Yimin</creatorcontrib><title>Non‐16/18 high‐risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL</title><title>Cancer cytopathology</title><addtitle>Cancer Cytopathol</addtitle><description>BACKGROUND
The current management strategy for women with low‐grade squamous intraepithelial lesions (LSILs) is inefficient and expensive because of the inability to identify patients at high risk for disease progression. The current study was designed to determine the genotypic patterns of human papillomavirus (HPV) associated with the persistence and progression of cervical lesions in women with an initial interpretation of LSIL.
METHODS
One hundred sixty‐seven women with LSIL on Papanicolaou tests collected between December 1, 2009 and March 30, 2011 were studied. HPV DNA was extracted from residual SurePath specimens, genotypes were determined with a DNA microarray containing 40 HPV genotype probes, and microarray data were confirmed by sequencing. Follow‐up Papanicolaou tests and/or biopsies were performed within a 20‐ to 46‐month period after the initial diagnosis.
RESULTS
Ninety‐seven of the 167 cases with follow‐up results were included in the study. Compared with the women with a regressed cervical lesion, those with a persistent cervical lesion (PCL) were significantly more commonly infected with high‐risk human papillomavirus (HR‐HPV) genotypes (P < .01) and particularly with non‐16/18 HR‐HPV genotypes (P < .05). The PCL group also had a significantly higher average number of HR‐HPV genotypes and non‐16/18 HPV genotypes per specimen (P < .01). Infection with HPV‐16/18 genotypes was not significantly associated with the persistence or progression of cervical lesions.
CONCLUSIONS
Infection with non‐16/18 HR‐HPV genotypes but not with HPV‐16/18 genotypes was a strong predictor of the persistence and progression of cervical disease upon follow‐up. Genotyping solely for HPV‐16/18 would miss the majority of patients with LSIL who progress to high‐grade squamous intraepithelial lesions. Pooled HR‐HPV tests provide a better predictive value than HPV‐16/18 genotyping alone in guiding the clinical management of patients with LSIL. Cancer (Cancer Cytopathol) 2015;123:435‐42. © 2015 American Cancer Society.
Non‐16/18 high‐risk human papillomavirus genotypes strongly predict persistent cervical lesions and progression to high‐grade lesions in women with an initial cytology interpretation of a low‐grade squamous intraepithelial lesion.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cervical Intraepithelial Neoplasia - genetics</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervical Intraepithelial Neoplasia - physiopathology</subject><subject>China - epidemiology</subject><subject>Chronic Disease</subject><subject>Cohort Studies</subject><subject>Disease Progression</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>human papillomavirus (HPV)</subject><subject>Human papillomavirus 16 - genetics</subject><subject>Human papillomavirus 18 - genetics</subject><subject>human papillomavirus genotyping</subject><subject>Humans</subject><subject>low‐grade squamous intraepithelial lesion</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>non‐16/18 high‐risk human papillomavirus genotypes</subject><subject>Papanicolaou Test</subject><subject>Papillomavirus Infections - epidemiology</subject><subject>Papillomavirus Infections - genetics</subject><subject>Papillomavirus Infections - pathology</subject><subject>persistent cervical dysplasia</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>progression of cervical disease</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Vaginal Smears</subject><subject>Young Adult</subject><issn>1934-662X</issn><issn>1934-6638</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctKAzEUhoMotl42PoAE3IhQm-t0spTiDYoKXtDVEDMnNnWaqcmU0p34BD6jT2Jq1YULNzk5ycfH4fwI7VBySAlhXePN_JBRKdQKalPFRSfLeL76e2f3LbQR44gQmvcYXUctJhXhhMo2eruo_cfrO826NMdD9zRMTXDxGZ9d3WHnLZjG1R5PApTONBGXLoKOgCcQoosNeANY-zIB9VOAGBew83hWjyGdrhmm3_TgGqerVBsISdXoL2lt8eD6fLCF1qyuImx_1010e3J80z_rDC5Pz_tHg47hiqtObkUpBIBipRacq16uhLU5WKGZ7WVUspKVhijNJAejMyVYpiRn3DwqJqnlm2h_6U2zvkwhNsXYRQNVpT3U01jQTKXtMClpQvf-oKN6GnyabkFlhHMpe4k6WFIm1DEGsMUkuLEO84KSYpFMsUim-EomwbvfyunjGMpf9CeKBNAlMHMVzP9RFf2L_sNS-gnHrZqe</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Lyons, Yasmin A.</creator><creator>Kamat, Aparna A.</creator><creator>Zhou, Haijun</creator><creator>Mody, Dina R.</creator><creator>Schwartz, Mary R.</creator><creator>Hobday, Christopher</creator><creator>Ge, Yimin</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201507</creationdate><title>Non‐16/18 high‐risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL</title><author>Lyons, Yasmin A. ; Kamat, Aparna A. ; Zhou, Haijun ; Mody, Dina R. ; Schwartz, Mary R. ; Hobday, Christopher ; Ge, Yimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3939-8f4d44ee92da43397894ff8ef4a2f76152d2dc09a253eca6942695323cb9251f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cervical Intraepithelial Neoplasia - genetics</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervical Intraepithelial Neoplasia - physiopathology</topic><topic>China - epidemiology</topic><topic>Chronic Disease</topic><topic>Cohort Studies</topic><topic>Disease Progression</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>human papillomavirus (HPV)</topic><topic>Human papillomavirus 16 - genetics</topic><topic>Human papillomavirus 18 - genetics</topic><topic>human papillomavirus genotyping</topic><topic>Humans</topic><topic>low‐grade squamous intraepithelial lesion</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>non‐16/18 high‐risk human papillomavirus genotypes</topic><topic>Papanicolaou Test</topic><topic>Papillomavirus Infections - epidemiology</topic><topic>Papillomavirus Infections - genetics</topic><topic>Papillomavirus Infections - pathology</topic><topic>persistent cervical dysplasia</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>progression of cervical disease</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Vaginal Smears</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Lyons, Yasmin A.</creatorcontrib><creatorcontrib>Kamat, Aparna A.</creatorcontrib><creatorcontrib>Zhou, Haijun</creatorcontrib><creatorcontrib>Mody, Dina R.</creatorcontrib><creatorcontrib>Schwartz, Mary R.</creatorcontrib><creatorcontrib>Hobday, Christopher</creatorcontrib><creatorcontrib>Ge, Yimin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer cytopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lyons, Yasmin A.</au><au>Kamat, Aparna A.</au><au>Zhou, Haijun</au><au>Mody, Dina R.</au><au>Schwartz, Mary R.</au><au>Hobday, Christopher</au><au>Ge, Yimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non‐16/18 high‐risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL</atitle><jtitle>Cancer cytopathology</jtitle><addtitle>Cancer Cytopathol</addtitle><date>2015-07</date><risdate>2015</risdate><volume>123</volume><issue>7</issue><spage>435</spage><epage>442</epage><pages>435-442</pages><issn>1934-662X</issn><eissn>1934-6638</eissn><coden>CANCAR</coden><abstract>BACKGROUND
The current management strategy for women with low‐grade squamous intraepithelial lesions (LSILs) is inefficient and expensive because of the inability to identify patients at high risk for disease progression. The current study was designed to determine the genotypic patterns of human papillomavirus (HPV) associated with the persistence and progression of cervical lesions in women with an initial interpretation of LSIL.
METHODS
One hundred sixty‐seven women with LSIL on Papanicolaou tests collected between December 1, 2009 and March 30, 2011 were studied. HPV DNA was extracted from residual SurePath specimens, genotypes were determined with a DNA microarray containing 40 HPV genotype probes, and microarray data were confirmed by sequencing. Follow‐up Papanicolaou tests and/or biopsies were performed within a 20‐ to 46‐month period after the initial diagnosis.
RESULTS
Ninety‐seven of the 167 cases with follow‐up results were included in the study. Compared with the women with a regressed cervical lesion, those with a persistent cervical lesion (PCL) were significantly more commonly infected with high‐risk human papillomavirus (HR‐HPV) genotypes (P < .01) and particularly with non‐16/18 HR‐HPV genotypes (P < .05). The PCL group also had a significantly higher average number of HR‐HPV genotypes and non‐16/18 HPV genotypes per specimen (P < .01). Infection with HPV‐16/18 genotypes was not significantly associated with the persistence or progression of cervical lesions.
CONCLUSIONS
Infection with non‐16/18 HR‐HPV genotypes but not with HPV‐16/18 genotypes was a strong predictor of the persistence and progression of cervical disease upon follow‐up. Genotyping solely for HPV‐16/18 would miss the majority of patients with LSIL who progress to high‐grade squamous intraepithelial lesions. Pooled HR‐HPV tests provide a better predictive value than HPV‐16/18 genotyping alone in guiding the clinical management of patients with LSIL. Cancer (Cancer Cytopathol) 2015;123:435‐42. © 2015 American Cancer Society.
Non‐16/18 high‐risk human papillomavirus genotypes strongly predict persistent cervical lesions and progression to high‐grade lesions in women with an initial cytology interpretation of a low‐grade squamous intraepithelial lesion.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>25903015</pmid><doi>10.1002/cncy.21549</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - physiopathology China - epidemiology Chronic Disease Cohort Studies Disease Progression DNA, Viral - genetics Female Genotype human papillomavirus (HPV) Human papillomavirus 16 - genetics Human papillomavirus 18 - genetics human papillomavirus genotyping Humans low‐grade squamous intraepithelial lesion Middle Aged Neoplasm Invasiveness - pathology non‐16/18 high‐risk human papillomavirus genotypes Papanicolaou Test Papillomavirus Infections - epidemiology Papillomavirus Infections - genetics Papillomavirus Infections - pathology persistent cervical dysplasia Predictive Value of Tests Prevalence progression of cervical disease Retrospective Studies Risk Assessment Vaginal Smears Young Adult |
| title | Non‐16/18 high‐risk HPV infection predicts disease persistence and progression in women with an initial interpretation of LSIL |
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