Activation of recombinant murine cytotoxic cell proteinase-1 requires deletion of an amino-terminal dipeptide

Murine cytotoxic cell proteinase-1 (granzyme B) is a member of a family of novel serine proteinases that have been implicated to participate in destruction of target cells by cytotoxic T lymphocytes. Comparison of the sequence of the cDNA with the sequence of the protein isolated from cytoplasmic gr...

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Veröffentlicht in:	The Journal of biological chemistry 1993-08, Vol.268 (24), p.17672-17675
Hauptverfasser:	Caputo, A., Garner, R.S., Winkler, U., Hudig, D., Bleackley, R.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Antibodies Base Sequence Biological and medical sciences Biotechnology Blotting, Western Dipeptides DNA Electrophoresis, Polyacrylamide Gel Enzyme Activation Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Granzymes Hydrolases Mice Molecular Sequence Data Molecular Weight Mutagenesis, Site-Directed Oligodeoxyribonucleotides Recombinant Proteins - biosynthesis Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Sequence Deletion Serine Endopeptidases - biosynthesis Serine Endopeptidases - isolation & purification Serine Endopeptidases - metabolism T-Lymphocytes, Cytotoxic - enzymology Transfection
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