Convergent Synthesis of the Polyene Macrolide (-)-Roxaticin

(-)-Roxaticin has been synthesized from polyol tetraacetonide 5, which was prepared by a threefold convergent route. Each of the optically pure building blocks (2, 3, and 4) was prepared using a Noyori asymmetric hydrogenation. Sequential alkylation of dibromide 3 with cyanohydrin acetonides 2 and 4...

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Veröffentlicht in:	Journal of the American Chemical Society 1994-03, Vol.116 (5), p.1753-1765
Hauptverfasser:	Rychnovsky, Scott D, Hoye, Rebecca C
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Organic chemistry Preparations and properties Streptomyces
Online-Zugang:	Volltext
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