Conformationally Defined 6-s-trans-Retinoic Acid Analogs. 2. Selective Agonists for Nuclear Receptor Binding and Transcriptional Activity

We recently demonstrated in animal models that a new conformationally defined RA isomer (Vaezi et al. J. Med. Chem. 1994, 37, 4499-4507) was as effective as RA in the prevention of skin papillomas but was less toxic. In order to provide more details concerning this improved action, we report here th...

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Veröffentlicht in:Journal of medicinal chemistry 1995-06, Vol.38 (13), p.2302-2310
Hauptverfasser: Alam, Muzaffar, Zhestkov, Valdimir, Sani, Brahma P, Venepally, Pratap, Levin, Arthur A, Kazmer, Sonja, Li, Ellen, Norris, Andrew W, Zhang, Xiao-kun
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Sprache:eng
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