Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5‑HT Receptor Mechanisms and Concerted Effects of 5‑HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine

It has been known for several decades that serotonergic neurotransmission is a key regulator of cognitive function, mood, and sleep. Yet with the relatively recent discoveries of novel serotonin (5-HT) receptor subtypes, as well as an expanding knowledge of their expression level in certain brain re...

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Veröffentlicht in:	ACS chemical neuroscience 2015-07, Vol.6 (7), p.970-986
Hauptverfasser:	Leiser, Steven C, Li, Yan, Pehrson, Alan L, Dale, Elena, Smagin, Gennady, Sanchez, Connie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - pharmacology Cognition - drug effects Cognition - physiology Humans Neural Pathways - drug effects Neural Pathways - metabolism Piperazines - pharmacology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Receptors, Serotonin - metabolism Serotonin Uptake Inhibitors - pharmacology Sulfides - pharmacology
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