An Orally Active Phenylaminotetralin-Chemotype Serotonin 5‑HT7 and 5‑HT1A Receptor Partial Agonist That Corrects Motor Stereotypy in Mouse Models

Stereotypy (e.g., repetitive hand waving) is a key phenotype of autism spectrum disorder, Fragile X and Rett syndromes, and other neuropsychiatric disorders, and its severity correlates with cognitive and attention deficits. There are no effective treatments, however, for stereotypy. Perturbation of...

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Veröffentlicht in:	ACS chemical neuroscience 2015-07, Vol.6 (7), p.1259-1270
Hauptverfasser:	Canal, Clinton E, Felsing, Daniel E, Liu, Yue, Zhu, Wanying, Wood, JodiAnne T, Perry, Charles K, Vemula, Rajender, Booth, Raymond G
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Naphthylamine - analogs & derivatives 2-Naphthylamine - pharmacokinetics 2-Naphthylamine - pharmacology Administration, Oral Amphetamines Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain - drug effects Brain - metabolism Disease Models, Animal Dizocilpine Maleate Dose-Response Relationship, Drug HEK293 Cells Humans Locomotion - drug effects Locomotion - physiology Male Mice, Inbred C57BL Molecular Structure Receptor, Serotonin, 5-HT1A - metabolism Receptors, Serotonin - metabolism Serotonin Receptor Agonists - pharmacokinetics Serotonin Receptor Agonists - pharmacology Social Behavior Stereotyped Behavior - drug effects Stereotyped Behavior - physiology Tetrahydronaphthalenes - pharmacokinetics Tetrahydronaphthalenes - pharmacology
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