The BCL2 Major Breakpoint Region is a Sequence- and Cell-Cycle-Specific Binding Site of the Ku Antigen

The majority of translocations involving BCL2 are very narrowly targeted to three breakpoint clusters evenly spaced over a 100-bp region of the gene's terminal exon. We have recently shown that the immediate upstream boundary of this major breakpoint region (mbr) is a specific recognition site...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-10, Vol.92 (22), p.10137-10141
Hauptverfasser:	DiCroce, Patricia A., Krontiris, Theodore G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Antigens, Nuclear Base Sequence Bcl-2 gene Binding Sites Carrier proteins Cell Cycle Cell Line Cell lines Consensus Sequence Deoxyribonucleic acid DNA DNA helicase DNA Helicases DNA Primers DNA, Neoplasm - chemistry DNA, Neoplasm - metabolism DNA-binding protein DNA-Binding Proteins - metabolism Elution Exons Genetics HL-60 Cells Humans Ku antigen Ku Autoantigen Leukemia, T-Cell man Mice Molecular Sequence Data Nuclear Proteins - metabolism Polymerase Chain Reaction Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcl-2 Proto-Oncogenes T lymphocytes Transcription Factors - metabolism Translocation, Genetic Tumor Cells, Cultured
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