Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia

Sickling of red cells in patients with sickle cell anemia is caused by the polymerization of molecules of deoxygenated hemoglobin S (α 2 β 2 s) into rigid, rod-like polymers. Fetal hemoglobin (α 2 γ 2 ), which lacks β-globin chains, inhibits sickling in vitro by interfering with the polymerization o...

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