The role of autophagy in bacterial infections
Autophagy is a highly conserved catabolic process for the degradation of cytosolic components including damaged organelles, protein aggregates, and intracellular bacteria through a lysosome-dependent pathway. Autophagy can be induced in response to stress conditions. Furthermore, autophagy has been...
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| Veröffentlicht in: | BioScience Trends 2015, Vol.9(3), pp.149-159 |
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| container_title | BioScience Trends |
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| creator | Castrejón-Jiménez, Nayeli Shantal Leyva-Paredes, Kahiry Hernández-González, Juan Carlos Luna-Herrera, Julieta García-Pérez, Blanca Estela |
| description | Autophagy is a highly conserved catabolic process for the degradation of cytosolic components including damaged organelles, protein aggregates, and intracellular bacteria through a lysosome-dependent pathway. Autophagy can be induced in response to stress conditions. Furthermore, autophagy has been described as involved in both innate and adaptive immune responses, and several studies have shown that certain microorganisms can be eliminated by the autophagic route in a process known as xenophagy. However, several pathogens have developed different strategies to evade or exploit autophagy to ensure their survival. Here, we review the role of autophagy in response to bacterial pathogens. |
| doi_str_mv | 10.5582/bst.2015.01035 |
| format | Article |
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| ispartof | BioScience Trends, 2015, Vol.9(3), pp.149-159 |
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| language | eng |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adaptive Immunity - physiology Animals Autophagy Autophagy - physiology Bacterial Infections - microbiology Bacterial Infections - physiopathology Coxiella burnetii Cytosol - metabolism Humans Legionella pneumophila Listeria monocytogenes Lysosomes - metabolism Mycobacterium tuberculosis pathogens Porphyromonas gingivalis Salmonella typhimurium selective autophagy Shigella flexneri Streptococcus pyogenes xenophagy |
| title | The role of autophagy in bacterial infections |
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