Ayahuasca Alters Structural Parameters of the Rat Aorta
Ayahuasca is a hallucinogenic brew traditionally used by Northwestern Amazonian indigenous groups for therapeutic purposes. It is prepared by the decoction of Banisteriopsis caapi with the leaves of Psychotria viridis. Banisteriopsis caapi contains β-carbolines that are inhibitors of monoamine oxida...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 2015-07, Vol.66 (1), p.58-62 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Pitol, Dimitrius L Siéssere, Selma dos Santos, Rafael G Rosa, Maria L. N M Hallak, Jaime E C Scalize, Priscilla H Pereira, Bruno F Iyomasa, Melina M Semprini, Marisa Riba, Jordi Regalo, Simone C H |
| description | Ayahuasca is a hallucinogenic brew traditionally used by Northwestern Amazonian indigenous groups for therapeutic purposes. It is prepared by the decoction of Banisteriopsis caapi with the leaves of Psychotria viridis. Banisteriopsis caapi contains β-carbolines that are inhibitors of monoamine oxidase and P. viris is rich in dimethyltryptamine, a 5-HT1A/2A/2C agonist. Acute ayahuasca administration produces moderate cardiovascular effects in healthy volunteers, but information regarding long-term use is lacking. This study investigated the effects of ayahuasca (2–4 mL/kg) in the rat aorta after acute and chronic (14 days) administration. Ayahuasca caused flattening and stretching of vascular smooth muscle cells and changes in the arrangement and distribution of collagen and elastic fibers. Chronic treatment with the higher dose significantly increased media thickness and the ratio of media thickness to lumen diameter. More research is needed on the cardiovascular function of long-term ayahuasca consumers. |
| doi_str_mv | 10.1097/FJC.0000000000000243 |
| format | Article |
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This study investigated the effects of ayahuasca (2–4 mL/kg) in the rat aorta after acute and chronic (14 days) administration. Ayahuasca caused flattening and stretching of vascular smooth muscle cells and changes in the arrangement and distribution of collagen and elastic fibers. Chronic treatment with the higher dose significantly increased media thickness and the ratio of media thickness to lumen diameter. More research is needed on the cardiovascular function of long-term ayahuasca consumers.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/FJC.0000000000000243</identifier><identifier>PMID: 25714595</identifier><language>eng</language><publisher>United States: Copyright Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Animals ; Aorta - cytology ; Aorta - drug effects ; Banisteriopsis ; Male ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Leaves ; Rats ; Rats, Wistar</subject><ispartof>Journal of cardiovascular pharmacology, 2015-07, Vol.66 (1), p.58-62</ispartof><rights>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3563-bf060541991fa0533b92335e438eb2d8069fc265ee3ce19b8dd2897d28ffe9ee3</citedby><cites>FETCH-LOGICAL-c3563-bf060541991fa0533b92335e438eb2d8069fc265ee3ce19b8dd2897d28ffe9ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27915,27916</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25714595$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pitol, Dimitrius L</creatorcontrib><creatorcontrib>Siéssere, Selma</creatorcontrib><creatorcontrib>dos Santos, Rafael G</creatorcontrib><creatorcontrib>Rosa, Maria L. N M</creatorcontrib><creatorcontrib>Hallak, Jaime E C</creatorcontrib><creatorcontrib>Scalize, Priscilla H</creatorcontrib><creatorcontrib>Pereira, Bruno F</creatorcontrib><creatorcontrib>Iyomasa, Melina M</creatorcontrib><creatorcontrib>Semprini, Marisa</creatorcontrib><creatorcontrib>Riba, Jordi</creatorcontrib><creatorcontrib>Regalo, Simone C H</creatorcontrib><title>Ayahuasca Alters Structural Parameters of the Rat Aorta</title><title>Journal of cardiovascular pharmacology</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>Ayahuasca is a hallucinogenic brew traditionally used by Northwestern Amazonian indigenous groups for therapeutic purposes. It is prepared by the decoction of Banisteriopsis caapi with the leaves of Psychotria viridis. Banisteriopsis caapi contains β-carbolines that are inhibitors of monoamine oxidase and P. viris is rich in dimethyltryptamine, a 5-HT1A/2A/2C agonist. Acute ayahuasca administration produces moderate cardiovascular effects in healthy volunteers, but information regarding long-term use is lacking. This study investigated the effects of ayahuasca (2–4 mL/kg) in the rat aorta after acute and chronic (14 days) administration. Ayahuasca caused flattening and stretching of vascular smooth muscle cells and changes in the arrangement and distribution of collagen and elastic fibers. Chronic treatment with the higher dose significantly increased media thickness and the ratio of media thickness to lumen diameter. More research is needed on the cardiovascular function of long-term ayahuasca consumers.</description><subject>Animals</subject><subject>Aorta - cytology</subject><subject>Aorta - drug effects</subject><subject>Banisteriopsis</subject><subject>Male</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3-A5EcvaTud7LHUKwfFBQ_zssmmSXVxNTdDaX_3rVVEQ_OYWYY3nlneBA6JXhKsMou5rezKf4dlLM9NCaCsZRjyvbRGBOJU8q5HKEj718wJlxk8hCNqMhiq8QYZcXGNIPxlUmKNoDzyWNwQxUGZ9rk3jjTwXba2yQ0kDyYkBS9C-YYHVjTejj5qhP0PL98ml2ni7urm1mxSCsmJEtLiyUWnChFrMHxtVJRxgRwlkNJ6xxLZSsqBQCrgKgyr2uaqywma0HF6QSd73xXrn8fwAfdLX0FbWveoB-8JlJJkiuRsyjlO2nleu8dWL1yy864jSZYfyLTEZn-iyyunX1dGMoO6p-lb0ZRkO8E635L6LUd1uB0A6YNzf_eH4gJdg8</recordid><startdate>201507</startdate><enddate>201507</enddate><creator>Pitol, Dimitrius L</creator><creator>Siéssere, Selma</creator><creator>dos Santos, Rafael G</creator><creator>Rosa, Maria L. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload |
| subjects | Animals Aorta - cytology Aorta - drug effects Banisteriopsis Male Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Leaves Rats Rats, Wistar |
| title | Ayahuasca Alters Structural Parameters of the Rat Aorta |
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