Cation Diffusion Facilitator family: Structure and function
The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal...
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| Veröffentlicht in: | FEBS letters 2015-05, Vol.589 (12), p.1283-1295 |
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| creator | Kolaj-Robin, Olga Russell, David Hayes, Kevin A. Pembroke, J. Tony Soulimane, Tewfik |
| description | The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn2+ and Cd2+ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings. |
| doi_str_mv | 10.1016/j.febslet.2015.04.007 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6138-3ba333dc872bd936104fce4d8e77a10028b06f48469b9f7c5103983496ae78d53</citedby><cites>FETCH-LOGICAL-c6138-3ba333dc872bd936104fce4d8e77a10028b06f48469b9f7c5103983496ae78d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2015.04.007$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2015.04.007$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,1432,3548,27923,27924,45573,45574,45994,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25896018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolaj-Robin, Olga</creatorcontrib><creatorcontrib>Russell, David</creatorcontrib><creatorcontrib>Hayes, Kevin A.</creatorcontrib><creatorcontrib>Pembroke, J. Tony</creatorcontrib><creatorcontrib>Soulimane, Tewfik</creatorcontrib><title>Cation Diffusion Facilitator family: Structure and function</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The Cation Diffusion Facilitators (CDFs) form a family of membrane-bound proteins capable of transporting zinc and other heavy metal ions. Involved in metal tolerance/resistance by efflux of ions, CDF proteins share a two-modular architecture consisting of a transmembrane domain (TMD) and C-terminal domain (CTD) that protrudes into the cytoplasm. Discovery of a Zn2+ and Cd2+ CDF transporter from a marine bacterium Maricaulis maris that does not possess the CTD questions current perceptions regarding this family of proteins. This article describes a new, CTD-lacking subfamily of CDFs and our current knowledge about this family of proteins in the view of these findings.</description><subject>Alphaproteobacteria - metabolism</subject><subject>Animals</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacterial Proteins - metabolism</subject><subject>Binding Sites</subject><subject>Biological Transport</subject><subject>C-terminal domain</subject><subject>Cation Diffusion Facilitator</subject><subject>Cation Transport Proteins - chemistry</subject><subject>Cation Transport Proteins - metabolism</subject><subject>CDF</subject><subject>CTD</subject><subject>extracellular loop</subject><subject>Humans</subject><subject>IL2</subject><subject>intracellular loop 2</subject><subject>isothermal titration calorimetry</subject><subject>ITC</subject><subject>Kinetics</subject><subject>Maricaulis maris</subject><subject>Membrane protein</subject><subject>Metals, Heavy - metabolism</subject><subject>Models, Molecular</subject><subject>Molecular Dynamics</subject><subject>Phylogeny</subject><subject>Protein Conformation</subject><subject>Protein Isoforms - chemistry</subject><subject>Protein Isoforms - metabolism</subject><subject>resistance nodulation and division</subject><subject>RND</subject><subject>SAXS</subject><subject>SEC-MALS</subject><subject>size exclusion chromatography multi-angle light scattering</subject><subject>SlC</subject><subject>small angle X-ray scattering</subject><subject>solute carrier</subject><subject>TMD</subject><subject>transmembrane domain</subject><subject>zinc resistance conferring</subject><subject>Zinc transporter</subject><subject>ZnT</subject><subject>Zrc</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9P4zAQxS3EalvKfgRQjlySteP_cEBsobASEofC2XKcseQqTcBOQP32m6iF63Iaj_Tem_FvEDojuCCYiN-bwkOVGuiLEhNeYFZgLI_QnChJc8qEOkZzjAnLudR0hk5S2uCxV0T_RLOSKy3GZo6ulrYPXZvdBu-HNL1W1oUm9LbvYubtNjS7y2zdx8H1Q4TMtnXmh9ZNplP0w9smwa9DXaCX1d3z8iF_fLr_u7x5zJ0gVOW0spTS2ilZVrWmgmDmHbBagZSWYFyqCgvPFBO60l46TjDVijItLEhVc7pAF_vc19i9DZB6sw3JQdPYFrohGSK0IIoLWY5Svpe62KUUwZvXGLY27gzBZuJmNubAzUzcDGZm5Db6zg8jhmoL9ZfrE9QoeNgLPkIDu--lmtXdn3I9HWG6AeHjVxmfoq73UTAyew8QTXIBWgd1iOB6U3fhP9v-A9rmlUY</recordid><startdate>20150522</startdate><enddate>20150522</enddate><creator>Kolaj-Robin, Olga</creator><creator>Russell, David</creator><creator>Hayes, Kevin A.</creator><creator>Pembroke, J. 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Tony ; Soulimane, Tewfik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6138-3ba333dc872bd936104fce4d8e77a10028b06f48469b9f7c5103983496ae78d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alphaproteobacteria - metabolism</topic><topic>Animals</topic><topic>Bacterial Proteins - chemistry</topic><topic>Bacterial Proteins - metabolism</topic><topic>Binding Sites</topic><topic>Biological Transport</topic><topic>C-terminal domain</topic><topic>Cation Diffusion Facilitator</topic><topic>Cation Transport Proteins - chemistry</topic><topic>Cation Transport Proteins - metabolism</topic><topic>CDF</topic><topic>CTD</topic><topic>extracellular loop</topic><topic>Humans</topic><topic>IL2</topic><topic>intracellular loop 2</topic><topic>isothermal titration calorimetry</topic><topic>ITC</topic><topic>Kinetics</topic><topic>Maricaulis maris</topic><topic>Membrane protein</topic><topic>Metals, Heavy - metabolism</topic><topic>Models, Molecular</topic><topic>Molecular Dynamics</topic><topic>Phylogeny</topic><topic>Protein Conformation</topic><topic>Protein Isoforms - chemistry</topic><topic>Protein Isoforms - metabolism</topic><topic>resistance nodulation and division</topic><topic>RND</topic><topic>SAXS</topic><topic>SEC-MALS</topic><topic>size exclusion chromatography multi-angle light scattering</topic><topic>SlC</topic><topic>small angle X-ray scattering</topic><topic>solute carrier</topic><topic>TMD</topic><topic>transmembrane domain</topic><topic>zinc resistance conferring</topic><topic>Zinc transporter</topic><topic>ZnT</topic><topic>Zrc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolaj-Robin, Olga</creatorcontrib><creatorcontrib>Russell, David</creatorcontrib><creatorcontrib>Hayes, Kevin A.</creatorcontrib><creatorcontrib>Pembroke, J. 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| subjects | Alphaproteobacteria - metabolism Animals Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding Sites Biological Transport C-terminal domain Cation Diffusion Facilitator Cation Transport Proteins - chemistry Cation Transport Proteins - metabolism CDF CTD extracellular loop Humans IL2 intracellular loop 2 isothermal titration calorimetry ITC Kinetics Maricaulis maris Membrane protein Metals, Heavy - metabolism Models, Molecular Molecular Dynamics Phylogeny Protein Conformation Protein Isoforms - chemistry Protein Isoforms - metabolism resistance nodulation and division RND SAXS SEC-MALS size exclusion chromatography multi-angle light scattering SlC small angle X-ray scattering solute carrier TMD transmembrane domain zinc resistance conferring Zinc transporter ZnT Zrc |
| title | Cation Diffusion Facilitator family: Structure and function |
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