Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Polycomb repressive complex 2 (PRC2) is a chromatin modifier that regulates stem cells in embryonic and adult tissues. Loss-of-function studies of PRC2 components have been complicated by early embryonic dependence on PRC2 activity and the partial functional redundancy of enhancer of zeste homolog 1...

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Veröffentlicht in:	Blood 2015-07, Vol.126 (2), p.167-175
Hauptverfasser:	Lee, StanleyC.W., Miller, Sarah, Hyland, Craig, Kauppi, Maria, Lebois, Marion, Di Rago, Ladina, Metcalf, Donald, Kinkel, Sarah A., Josefsson, Emma C., Blewitt, Marnie E., Majewski, Ian J., Alexander, Warren S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - genetics Cells, Cultured Fetus - immunology Fetus - physiology Hematopoiesis Hematopoietic Stem Cells - metabolism Hematopoietic Stem Cells - physiology Lymphopoiesis - genetics Mice Mice, Inbred C57BL Mice, Transgenic Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - physiology
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