A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity
Adhesion is of pivotal importance for a number of leukocyte functions. Little is known about the binding between leukocyte integrins and the intercellular adhesion molecules (ICAMs). Normally integrins are nonadhesive, and require a stimulus to become active. We have now identified a peptide from IC...
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| Veröffentlicht in: | The Journal of biological chemistry 1993-10, Vol.268 (29), p.21474-21477 |
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| container_issue | 29 |
| container_start_page | 21474 |
| container_title | The Journal of biological chemistry |
| container_volume | 268 |
| creator | RUI LI NORTAMO, P KANTOR, C KOVANEN, P TIMONEN, T GAHMBERG, C. G |
| description | Adhesion is of pivotal importance for a number of leukocyte functions. Little is known about the binding between leukocyte
integrins and the intercellular adhesion molecules (ICAMs). Normally integrins are nonadhesive, and require a stimulus to
become active. We have now identified a peptide from ICAM-2, which binds to leukocyte integrins and activates adhesion. Furthermore,
the peptide strongly increased the binding and cytotoxicity of natural killer cells. These findings show that adhesion-dependent
leukocyte functions can be activated by ligand-derived peptides, and therefore provide evidence that the avidity of leukocyte
integrins is up-regulated by integrin-ligand interactions. |
| doi_str_mv | 10.1016/S0021-9258(20)80561-4 |
| format | Article |
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integrins and the intercellular adhesion molecules (ICAMs). Normally integrins are nonadhesive, and require a stimulus to
become active. We have now identified a peptide from ICAM-2, which binds to leukocyte integrins and activates adhesion. Furthermore,
the peptide strongly increased the binding and cytotoxicity of natural killer cells. These findings show that adhesion-dependent
leukocyte functions can be activated by ligand-derived peptides, and therefore provide evidence that the avidity of leukocyte
integrins is up-regulated by integrin-ligand interactions.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(20)80561-4</identifier><identifier>PMID: 8104939</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Biochemistry and Molecular Biology</publisher><subject>Alkaloids - pharmacology ; Amino Acid Sequence ; Analysis of the immune response. Humoral and cellular immunity ; Antigens, CD - metabolism ; Biological and medical sciences ; CD18 Antigens ; Cell Adhesion - drug effects ; Cell Adhesion Molecules - metabolism ; Cell interactions ; Cytotoxicity, Immunologic ; Ethers, Cyclic - pharmacology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Integrins - metabolism ; Killer Cells, Natural - immunology ; Lymphocyte Function-Associated Antigen-1 - metabolism ; Molecular Sequence Data ; Okadaic Acid ; Peptide Fragments - metabolism ; Protein Binding ; Protein Kinase C - antagonists & inhibitors ; Receptors, Leukocyte-Adhesion - metabolism ; Staurosporine ; T-Lymphocytes - cytology ; T-Lymphocytes - immunology ; Tumor Cells, Cultured</subject><ispartof>The Journal of biological chemistry, 1993-10, Vol.268 (29), p.21474-21477</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-5b807f6e84a5d51251bd556e823a2b8d3bccee7507a20e958df97368b406ffdc3</citedby><cites>FETCH-LOGICAL-c440t-5b807f6e84a5d51251bd556e823a2b8d3bccee7507a20e958df97368b406ffdc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3814033$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8104939$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RUI LI</creatorcontrib><creatorcontrib>NORTAMO, P</creatorcontrib><creatorcontrib>KANTOR, C</creatorcontrib><creatorcontrib>KOVANEN, P</creatorcontrib><creatorcontrib>TIMONEN, T</creatorcontrib><creatorcontrib>GAHMBERG, C. G</creatorcontrib><title>A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>Adhesion is of pivotal importance for a number of leukocyte functions. Little is known about the binding between leukocyte
integrins and the intercellular adhesion molecules (ICAMs). Normally integrins are nonadhesive, and require a stimulus to
become active. We have now identified a peptide from ICAM-2, which binds to leukocyte integrins and activates adhesion. Furthermore,
the peptide strongly increased the binding and cytotoxicity of natural killer cells. These findings show that adhesion-dependent
leukocyte functions can be activated by ligand-derived peptides, and therefore provide evidence that the avidity of leukocyte
integrins is up-regulated by integrin-ligand interactions.</description><subject>Alkaloids - pharmacology</subject><subject>Amino Acid Sequence</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Antigens, CD - metabolism</subject><subject>Biological and medical sciences</subject><subject>CD18 Antigens</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Cell interactions</subject><subject>Cytotoxicity, Immunologic</subject><subject>Ethers, Cyclic - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Integrins - metabolism</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocyte Function-Associated Antigen-1 - metabolism</subject><subject>Molecular Sequence Data</subject><subject>Okadaic Acid</subject><subject>Peptide Fragments - metabolism</subject><subject>Protein Binding</subject><subject>Protein Kinase C - antagonists & inhibitors</subject><subject>Receptors, Leukocyte-Adhesion - metabolism</subject><subject>Staurosporine</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor Cells, Cultured</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1q3DAUhUVpSSZpHyGgRSjNwq1-bXkZQpsWAl00he6ELF3PKJHliSQ3zBP0teuZmIk20uV89x5xD0IXlHymhNZffhHCaNUyqT4xcqWIrGkl3qAVJYpXXNI_b9HqiJyis5wfyHxES0_QiaLzg7cr9O8aB5geR7srgH0ssE4-4s5H5-Mab2FbvAPcp3E4qMlCCFMwCRu3gezHiIcxgJ0CVAzn4odZLJDxPd6Tr5SJDkdTpmQCfvQhQFoAW_xfX3bv0bvehAwflvsc_f729f7me3X38_bHzfVdZYUgpZKdIk1fgxJGOkmZpJ2Tcq4ZN6xTjnfWAjSSNIYRaKVyfdvwWnWC1H3vLD9HH1_mbtP4NEEuevB5_xMTYZyypnUrpWRyBuULaNOYc4Jeb5MfTNppSvQ-AH0IQO-3qxnRhwC0mPsuFoOpG8Adu5aNz_rloptsTeiTidbnI8YVFYTzV2zj15tnn0B3frQbGDSrZ79WMyoawf8DsRqcaA</recordid><startdate>19931015</startdate><enddate>19931015</enddate><creator>RUI LI</creator><creator>NORTAMO, P</creator><creator>KANTOR, C</creator><creator>KOVANEN, P</creator><creator>TIMONEN, T</creator><creator>GAHMBERG, C. G</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19931015</creationdate><title>A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity</title><author>RUI LI ; NORTAMO, P ; KANTOR, C ; KOVANEN, P ; TIMONEN, T ; GAHMBERG, C. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-5b807f6e84a5d51251bd556e823a2b8d3bccee7507a20e958df97368b406ffdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Alkaloids - pharmacology</topic><topic>Amino Acid Sequence</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Antigens, CD - metabolism</topic><topic>Biological and medical sciences</topic><topic>CD18 Antigens</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Cell interactions</topic><topic>Cytotoxicity, Immunologic</topic><topic>Ethers, Cyclic - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Integrins - metabolism</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocyte Function-Associated Antigen-1 - metabolism</topic><topic>Molecular Sequence Data</topic><topic>Okadaic Acid</topic><topic>Peptide Fragments - metabolism</topic><topic>Protein Binding</topic><topic>Protein Kinase C - antagonists & inhibitors</topic><topic>Receptors, Leukocyte-Adhesion - metabolism</topic><topic>Staurosporine</topic><topic>T-Lymphocytes - cytology</topic><topic>T-Lymphocytes - immunology</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RUI LI</creatorcontrib><creatorcontrib>NORTAMO, P</creatorcontrib><creatorcontrib>KANTOR, C</creatorcontrib><creatorcontrib>KOVANEN, P</creatorcontrib><creatorcontrib>TIMONEN, T</creatorcontrib><creatorcontrib>GAHMBERG, C. 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G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1993-10-15</date><risdate>1993</risdate><volume>268</volume><issue>29</issue><spage>21474</spage><epage>21477</epage><pages>21474-21477</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>Adhesion is of pivotal importance for a number of leukocyte functions. Little is known about the binding between leukocyte
integrins and the intercellular adhesion molecules (ICAMs). Normally integrins are nonadhesive, and require a stimulus to
become active. We have now identified a peptide from ICAM-2, which binds to leukocyte integrins and activates adhesion. Furthermore,
the peptide strongly increased the binding and cytotoxicity of natural killer cells. These findings show that adhesion-dependent
leukocyte functions can be activated by ligand-derived peptides, and therefore provide evidence that the avidity of leukocyte
integrins is up-regulated by integrin-ligand interactions.</abstract><cop>Bethesda, MD</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>8104939</pmid><doi>10.1016/S0021-9258(20)80561-4</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | The Journal of biological chemistry, 1993-10, Vol.268 (29), p.21474-21477 |
| issn | 0021-9258 1083-351X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alkaloids - pharmacology Amino Acid Sequence Analysis of the immune response. Humoral and cellular immunity Antigens, CD - metabolism Biological and medical sciences CD18 Antigens Cell Adhesion - drug effects Cell Adhesion Molecules - metabolism Cell interactions Cytotoxicity, Immunologic Ethers, Cyclic - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Integrins - metabolism Killer Cells, Natural - immunology Lymphocyte Function-Associated Antigen-1 - metabolism Molecular Sequence Data Okadaic Acid Peptide Fragments - metabolism Protein Binding Protein Kinase C - antagonists & inhibitors Receptors, Leukocyte-Adhesion - metabolism Staurosporine T-Lymphocytes - cytology T-Lymphocytes - immunology Tumor Cells, Cultured |
| title | A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity |
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