Novel central action of des-Asp-angiotensin I
Intracerebroventricularly administered des-Asp-angiotensin I, when prevented from degradation by prior administration of captopril, attenuated dose-dependently the central pressor actions of angiotensin II and angiotensin III in the spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. This...
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| Veröffentlicht in: | European journal of pharmacology 1994-05, Vol.257 (1), p.R1-R3 |
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| container_title | European journal of pharmacology |
| container_volume | 257 |
| creator | Sim, M.K. Radhakrishnan, R. |
| description | Intracerebroventricularly administered des-Asp-angiotensin I, when prevented from degradation by prior administration of captopril, attenuated dose-dependently the central pressor actions of angiotensin II and angiotensin III in the spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. This finding is the first demonstration of an intrinsic action of des-Asp-angiotensin I and, together with earlier finding of its increased production in the hypothalamus of the spontaneously hypertensive rat, may support the suggestion that the nonapeptide is a functional angiotensin that regulates the pressor action of angiotensin II and angiotensin III in the brain. |
| doi_str_mv | 10.1016/0014-2999(94)90714-5 |
| format | Article |
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This finding is the first demonstration of an intrinsic action of des-Asp-angiotensin I and, together with earlier finding of its increased production in the hypothalamus of the spontaneously hypertensive rat, may support the suggestion that the nonapeptide is a functional angiotensin that regulates the pressor action of angiotensin II and angiotensin III in the brain.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(94)90714-5</identifier><identifier>PMID: 8082685</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Angiotensin I - analogs & derivatives ; Angiotensin I - pharmacology ; Angiotensin II - antagonists & inhibitors ; Angiotensin III ; Angiotensin III - antagonists & inhibitors ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Captopril - pharmacology ; des-Asp-Angiotensin I ; Dose-Response Relationship, Drug ; Drug Interactions ; Endocrine kidney. 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This finding is the first demonstration of an intrinsic action of des-Asp-angiotensin I and, together with earlier finding of its increased production in the hypothalamus of the spontaneously hypertensive rat, may support the suggestion that the nonapeptide is a functional angiotensin that regulates the pressor action of angiotensin II and angiotensin III in the brain.</description><subject>Angiotensin I - analogs & derivatives</subject><subject>Angiotensin I - pharmacology</subject><subject>Angiotensin II - antagonists & inhibitors</subject><subject>Angiotensin III</subject><subject>Angiotensin III - antagonists & inhibitors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Captopril - pharmacology</subject><subject>des-Asp-Angiotensin I</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Endocrine kidney. Renin-angiotensin-aldosterone system</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamus - drug effects</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Spontaneously hypertensive rat (SHR)</subject><subject>Vertebrates: endocrinology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWqv_QGEPInqI5nOzuQil-FEoetFzSJOJRLa7NdkW_Pfu2tKjp2F4n3kZHoQuKLmjhJb3hFCBmdb6RotbTVS_yQM0opXSuN_YIRrtkRN0mvMXIURqJo_RcUUqVlZyhPBru4G6cNB0ydaFdV1sm6INhYeMJ3mFbfMZ2w6aHJtidoaOgq0znO_mGH08Pb5PX_D87Xk2ncyxE1R12DkSKhmoIpaWXNmKeSW8dCw4roAwT0OpibNcB8HkQiurgS-sLjn3JVjJx-h627tK7fcacmeWMTuoa9tAu86GllpKXg2g2IIutTknCGaV4tKmH0OJGSyZQYEZFBgtzJ8lM5xd7vrXiyX4_dFOS59f7XKbna1Dso2LeY8JopWkoscethj0LjYRkskuQuPAxwSuM76N___xC3OTgV8</recordid><startdate>19940512</startdate><enddate>19940512</enddate><creator>Sim, M.K.</creator><creator>Radhakrishnan, R.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19940512</creationdate><title>Novel central action of des-Asp-angiotensin I</title><author>Sim, M.K. ; Radhakrishnan, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-cc0f85f170a1637a82d74d5c2fc37e02d1f690ca39f425b97a9e3ba9633d6ea53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Angiotensin I - analogs & derivatives</topic><topic>Angiotensin I - pharmacology</topic><topic>Angiotensin II - antagonists & inhibitors</topic><topic>Angiotensin III</topic><topic>Angiotensin III - antagonists & inhibitors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Captopril - pharmacology</topic><topic>des-Asp-Angiotensin I</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Endocrine kidney. Renin-angiotensin-aldosterone system</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamus - drug effects</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Spontaneously hypertensive rat (SHR)</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sim, M.K.</creatorcontrib><creatorcontrib>Radhakrishnan, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sim, M.K.</au><au>Radhakrishnan, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel central action of des-Asp-angiotensin I</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1994-05-12</date><risdate>1994</risdate><volume>257</volume><issue>1</issue><spage>R1</spage><epage>R3</epage><pages>R1-R3</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Intracerebroventricularly administered des-Asp-angiotensin I, when prevented from degradation by prior administration of captopril, attenuated dose-dependently the central pressor actions of angiotensin II and angiotensin III in the spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats. This finding is the first demonstration of an intrinsic action of des-Asp-angiotensin I and, together with earlier finding of its increased production in the hypothalamus of the spontaneously hypertensive rat, may support the suggestion that the nonapeptide is a functional angiotensin that regulates the pressor action of angiotensin II and angiotensin III in the brain.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>8082685</pmid><doi>10.1016/0014-2999(94)90714-5</doi></addata></record> |
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| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 1994-05, Vol.257 (1), p.R1-R3 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Angiotensin I - analogs & derivatives Angiotensin I - pharmacology Angiotensin II - antagonists & inhibitors Angiotensin III Angiotensin III - antagonists & inhibitors Animals Biological and medical sciences Blood Pressure - drug effects Captopril - pharmacology des-Asp-Angiotensin I Dose-Response Relationship, Drug Drug Interactions Endocrine kidney. Renin-angiotensin-aldosterone system Fundamental and applied biological sciences. Psychology Hypothalamus - drug effects Injections, Intraventricular Male Rats Rats, Inbred SHR Rats, Inbred WKY Spontaneously hypertensive rat (SHR) Vertebrates: endocrinology |
| title | Novel central action of des-Asp-angiotensin I |
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