Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer

Polypyrimidine tract-binding protein (PTBP1) is an RNA-binding protein with various molecular functions related to RNA metabolism and a major repressive regulator of alternative splicing, causing exon skipping in numerous alternatively spliced pre-mRNAs. Here, we have investigated the role of PTBP1...

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Veröffentlicht in:	Molecular cancer therapeutics 2015-07, Vol.14 (7), p.1705-1716
Hauptverfasser:	Takahashi, Hidekazu, Nishimura, Junichi, Kagawa, Yoshinori, Kano, Yoshihiro, Takahashi, Yusuke, Wu, Xin, Hiraki, Masayuki, Hamabe, Atsushi, Konno, Masamitsu, Haraguchi, Naotsugu, Takemasa, Ichiro, Mizushima, Tsunekazu, Ishii, Masaru, Mimori, Koshi, Ishii, Hideshi, Doki, Yuichiro, Mori, Masaki, Yamamoto, Hirofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Line, Tumor Cell Proliferation - genetics Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - therapy Gene Expression Regulation, Neoplastic HCT116 Cells HEK293 Cells Heterogeneous-Nuclear Ribonucleoproteins - genetics Heterogeneous-Nuclear Ribonucleoproteins - metabolism HT29 Cells Humans Immunohistochemistry Polypyrimidine Tract-Binding Protein - genetics Polypyrimidine Tract-Binding Protein - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA Interference RNAi Therapeutics - methods Time-Lapse Imaging - methods Xenograft Model Antitumor Assays - methods
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