Age-Related Lipid Metabolic Signature in Human LMNA-Lipodystrophic Stem Cell-Derived Adipocytes

Context: Lamin A (LMNA)-linked lipodystrophies belong to a group of clinical disorders characterized by a redistribution of adipose tissue with a variable range of metabolic complications. The leading cause of these disorders is the nonphysiological accumulation of the lamin A precursor, prelamin A....

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2015-07, Vol.100 (7), p.E964-E973
Hauptverfasser:	Sánchez, Patricia, Infante, Arantza, de Eguino, Garbiñe Ruiz, Fuentes-Maestre, Jorge A, García-Verdugo, José Manuel, Rodríguez, Clara I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adipocytes - physiology Adolescent Adult Aging - metabolism Cell Differentiation Female Humans Lamin Type A - genetics Lipid Metabolism Lipodystrophy - genetics Lipodystrophy - metabolism Lipodystrophy - pathology Lipolysis Male Metabolome Metabolomics Middle Aged Stem Cells - pathology Stem Cells - physiology Young Adult
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