The timing of acid-induced increase in saliva secretion in transplanted submandibular glands
Abstract The purpose of this study was to determine the timing of acid-induced increase in saliva secretion and to investigate the possibility of parasympathetic reinnervation of transplanted submandibular glands (SMGs). Citric acid stimulation-induced changes in secretion of transplanted SMGs were...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2015-08, Vol.44 (8), p.1041-1047 |
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| creator | Liu, X.J Li, M Su, J.Z Xie, Z Yu, G.Y |
| description | Abstract The purpose of this study was to determine the timing of acid-induced increase in saliva secretion and to investigate the possibility of parasympathetic reinnervation of transplanted submandibular glands (SMGs). Citric acid stimulation-induced changes in secretion of transplanted SMGs were evaluated in 27 patients who underwent SMG transplantation for keratoconjunctivitis sicca (KCS);99m Tc scintigraphy and Schirmer tests were done at 1, 3, 6, and 9 months after transplantation. Acetylcholinesterase staining was conducted to confirm the presence of parasympathetic reinnervation in three SMGs at 6 and 9 months after transplantation. Schirmer tests showed significantly increased secretion of the transplanted SMGs after acid stimulation at 6 and 9 months, but not at 1 and 3 months. On99m Tc scintigraphy, no decline was detected on the dynamic time–activity curve after acid stimulation at 1 and 3 months, but a decline was detected in nine glands at 6 months and in 19 glands at 9 months. No decline was observed in the remaining eight glands at 9 months after transplantation. The histology findings were consistent with scintigraphy results. In conclusion, acid-induced increase in saliva secretion occurs at ≥6 months after SMG transplantation, and parasympathetic reinnervation of the transplanted SMG might occur. |
| doi_str_mv | 10.1016/j.ijom.2015.01.003 |
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Citric acid stimulation-induced changes in secretion of transplanted SMGs were evaluated in 27 patients who underwent SMG transplantation for keratoconjunctivitis sicca (KCS);99m Tc scintigraphy and Schirmer tests were done at 1, 3, 6, and 9 months after transplantation. Acetylcholinesterase staining was conducted to confirm the presence of parasympathetic reinnervation in three SMGs at 6 and 9 months after transplantation. Schirmer tests showed significantly increased secretion of the transplanted SMGs after acid stimulation at 6 and 9 months, but not at 1 and 3 months. On99m Tc scintigraphy, no decline was detected on the dynamic time–activity curve after acid stimulation at 1 and 3 months, but a decline was detected in nine glands at 6 months and in 19 glands at 9 months. No decline was observed in the remaining eight glands at 9 months after transplantation. The histology findings were consistent with scintigraphy results. In conclusion, acid-induced increase in saliva secretion occurs at ≥6 months after SMG transplantation, and parasympathetic reinnervation of the transplanted SMG might occur.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2015.01.003</identifier><identifier>PMID: 25697065</identifier><language>eng</language><publisher>Denmark: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Citric Acid - administration & dosage ; Dentistry ; Female ; Humans ; keratoconjunctivitis sicca ; Keratoconjunctivitis Sicca - diagnostic imaging ; Keratoconjunctivitis Sicca - surgery ; Male ; Middle Aged ; Radionuclide Imaging ; Radiopharmaceuticals ; reinnervation ; Saliva - secretion ; Salivation - drug effects ; Schirmer test ; scintigraphy ; Sodium Pertechnetate Tc 99m ; Staining and Labeling ; Submandibular Gland - secretion ; Submandibular Gland - transplantation ; Surgery ; Time Factors</subject><ispartof>International journal of oral and maxillofacial surgery, 2015-08, Vol.44 (8), p.1041-1047</ispartof><rights>International Association of Oral and Maxillofacial Surgeons</rights><rights>2015 International Association of Oral and Maxillofacial Surgeons</rights><rights>Copyright © 2015 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-609aeaa27c23efd9f97b1575132260b51168dfabed75ff76475c4140d7cd933b3</citedby><cites>FETCH-LOGICAL-c481t-609aeaa27c23efd9f97b1575132260b51168dfabed75ff76475c4140d7cd933b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijom.2015.01.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25697065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, X.J</creatorcontrib><creatorcontrib>Li, M</creatorcontrib><creatorcontrib>Su, J.Z</creatorcontrib><creatorcontrib>Xie, Z</creatorcontrib><creatorcontrib>Yu, G.Y</creatorcontrib><title>The timing of acid-induced increase in saliva secretion in transplanted submandibular glands</title><title>International journal of oral and maxillofacial surgery</title><addtitle>Int J Oral Maxillofac Surg</addtitle><description>Abstract The purpose of this study was to determine the timing of acid-induced increase in saliva secretion and to investigate the possibility of parasympathetic reinnervation of transplanted submandibular glands (SMGs). Citric acid stimulation-induced changes in secretion of transplanted SMGs were evaluated in 27 patients who underwent SMG transplantation for keratoconjunctivitis sicca (KCS);99m Tc scintigraphy and Schirmer tests were done at 1, 3, 6, and 9 months after transplantation. Acetylcholinesterase staining was conducted to confirm the presence of parasympathetic reinnervation in three SMGs at 6 and 9 months after transplantation. Schirmer tests showed significantly increased secretion of the transplanted SMGs after acid stimulation at 6 and 9 months, but not at 1 and 3 months. On99m Tc scintigraphy, no decline was detected on the dynamic time–activity curve after acid stimulation at 1 and 3 months, but a decline was detected in nine glands at 6 months and in 19 glands at 9 months. No decline was observed in the remaining eight glands at 9 months after transplantation. The histology findings were consistent with scintigraphy results. In conclusion, acid-induced increase in saliva secretion occurs at ≥6 months after SMG transplantation, and parasympathetic reinnervation of the transplanted SMG might occur.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Citric Acid - administration & dosage</subject><subject>Dentistry</subject><subject>Female</subject><subject>Humans</subject><subject>keratoconjunctivitis sicca</subject><subject>Keratoconjunctivitis Sicca - diagnostic imaging</subject><subject>Keratoconjunctivitis Sicca - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>reinnervation</subject><subject>Saliva - secretion</subject><subject>Salivation - drug effects</subject><subject>Schirmer test</subject><subject>scintigraphy</subject><subject>Sodium Pertechnetate Tc 99m</subject><subject>Staining and Labeling</subject><subject>Submandibular Gland - secretion</subject><subject>Submandibular Gland - transplantation</subject><subject>Surgery</subject><subject>Time Factors</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS0EotvCH-CAcuSSMOPE8VpCSKgqFKlSD7S3SpZjT4pD4ix2Uqn_HkdbOHDoxbae3nvyfMPYO4QKAduPQ-WHeao4oKgAK4D6BdthrVQJwOEl24ECLAVwecJOUxoAQNV7-ZqdcNEqCa3Ysbubn1QsfvLhvpj7wljvSh_caskVPthIJlF-FMmM_sEUibK0-Dls2hJNSIfRhCWb09pNJjjfraOJxX1WXXrDXvVmTPT26T5jt18vbs4vy6vrb9_Pv1yVttnjUragDBnDpeU19U71SnYopMCa8xY6gdjuXW86clL0vWwbKWyDDThpnarrrj5jH469hzj_XiktevLJ0pg_QfOaNLZKoGxFw7OVH602zilF6vUh-snER42gN6p60BtVvVHVgDpTzaH3T_15SHL_In8xZsOno4HylA-eok7WU8gQfSS7aDf75_s__xe3ow_emvEXPVIa5jWGzE-jTlyD_rHtdVtrPgAQZP0H6i-eDg</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Liu, X.J</creator><creator>Li, M</creator><creator>Su, J.Z</creator><creator>Xie, Z</creator><creator>Yu, G.Y</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>The timing of acid-induced increase in saliva secretion in transplanted submandibular glands</title><author>Liu, X.J ; Li, M ; Su, J.Z ; Xie, Z ; Yu, G.Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-609aeaa27c23efd9f97b1575132260b51168dfabed75ff76475c4140d7cd933b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Citric Acid - administration & dosage</topic><topic>Dentistry</topic><topic>Female</topic><topic>Humans</topic><topic>keratoconjunctivitis sicca</topic><topic>Keratoconjunctivitis Sicca - diagnostic imaging</topic><topic>Keratoconjunctivitis Sicca - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals</topic><topic>reinnervation</topic><topic>Saliva - secretion</topic><topic>Salivation - drug effects</topic><topic>Schirmer test</topic><topic>scintigraphy</topic><topic>Sodium Pertechnetate Tc 99m</topic><topic>Staining and Labeling</topic><topic>Submandibular Gland - secretion</topic><topic>Submandibular Gland - transplantation</topic><topic>Surgery</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, X.J</creatorcontrib><creatorcontrib>Li, M</creatorcontrib><creatorcontrib>Su, J.Z</creatorcontrib><creatorcontrib>Xie, Z</creatorcontrib><creatorcontrib>Yu, G.Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, X.J</au><au>Li, M</au><au>Su, J.Z</au><au>Xie, Z</au><au>Yu, G.Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The timing of acid-induced increase in saliva secretion in transplanted submandibular glands</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>44</volume><issue>8</issue><spage>1041</spage><epage>1047</epage><pages>1041-1047</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><abstract>Abstract The purpose of this study was to determine the timing of acid-induced increase in saliva secretion and to investigate the possibility of parasympathetic reinnervation of transplanted submandibular glands (SMGs). Citric acid stimulation-induced changes in secretion of transplanted SMGs were evaluated in 27 patients who underwent SMG transplantation for keratoconjunctivitis sicca (KCS);99m Tc scintigraphy and Schirmer tests were done at 1, 3, 6, and 9 months after transplantation. Acetylcholinesterase staining was conducted to confirm the presence of parasympathetic reinnervation in three SMGs at 6 and 9 months after transplantation. Schirmer tests showed significantly increased secretion of the transplanted SMGs after acid stimulation at 6 and 9 months, but not at 1 and 3 months. On99m Tc scintigraphy, no decline was detected on the dynamic time–activity curve after acid stimulation at 1 and 3 months, but a decline was detected in nine glands at 6 months and in 19 glands at 9 months. No decline was observed in the remaining eight glands at 9 months after transplantation. The histology findings were consistent with scintigraphy results. In conclusion, acid-induced increase in saliva secretion occurs at ≥6 months after SMG transplantation, and parasympathetic reinnervation of the transplanted SMG might occur.</abstract><cop>Denmark</cop><pub>Elsevier Ltd</pub><pmid>25697065</pmid><doi>10.1016/j.ijom.2015.01.003</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Citric Acid - administration & dosage Dentistry Female Humans keratoconjunctivitis sicca Keratoconjunctivitis Sicca - diagnostic imaging Keratoconjunctivitis Sicca - surgery Male Middle Aged Radionuclide Imaging Radiopharmaceuticals reinnervation Saliva - secretion Salivation - drug effects Schirmer test scintigraphy Sodium Pertechnetate Tc 99m Staining and Labeling Submandibular Gland - secretion Submandibular Gland - transplantation Surgery Time Factors |
| title | The timing of acid-induced increase in saliva secretion in transplanted submandibular glands |
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