Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT
Traumeel (Tr14) is a natural, combination drug, which has been shown to modulate inflammation at the cytokine level. This study aimed to investigate potential effects of Tr14 on the exercise‐induced immune response. In a double‐blind, randomized, controlled trial, healthy, untrained male subjects re...
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| Veröffentlicht in: | Scandinavian journal of medicine & science in sports 2015-08, Vol.25 (4), p.534-542 |
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| container_title | Scandinavian journal of medicine & science in sports |
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| creator | Pilat, C. Frech, T. Wagner, A. Krüger, K. Hillebrecht, A. Pons-Kühnemann, J. Scheibelhut, C. Bödeker, R.-H. Mooren, F.-C. |
| description | Traumeel (Tr14) is a natural, combination drug, which has been shown to modulate inflammation at the cytokine level. This study aimed to investigate potential effects of Tr14 on the exercise‐induced immune response. In a double‐blind, randomized, controlled trial, healthy, untrained male subjects received either Tr14 (n = 40) or placebo (n = 40) for 24 h after a strenuous experimental exercise trial on a bicycle (60 min at 80%VO2max). A range of antigen‐stimulated cytokines (in vitro), white blood cell count, lymphocyte activation and apoptosis markers, and indicators of muscle damage were assessed up to 24 h following exercise. The area under the curve with respect to the increase (AUCI) was compared between both groups. The Tr14 group showed a reduced exercise‐induced leukocytosis and neutrocytosis (P |
| doi_str_mv | 10.1111/sms.12265 |
| format | Article |
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This study aimed to investigate potential effects of Tr14 on the exercise‐induced immune response. In a double‐blind, randomized, controlled trial, healthy, untrained male subjects received either Tr14 (n = 40) or placebo (n = 40) for 24 h after a strenuous experimental exercise trial on a bicycle (60 min at 80%VO2max). A range of antigen‐stimulated cytokines (in vitro), white blood cell count, lymphocyte activation and apoptosis markers, and indicators of muscle damage were assessed up to 24 h following exercise. The area under the curve with respect to the increase (AUCI) was compared between both groups. The Tr14 group showed a reduced exercise‐induced leukocytosis and neutrocytosis (P < 0.01 for both), a higher AUCI score of antigen‐stimulated IL‐1β and IL‐1α (absolute and per monocyte, all P < 0.05), a lower AUCI score of antigen‐stimulated GM‐CSF (P < 0.05) and by trend a lower AUCI score of antigen‐stimulated IL‐2 and IL‐4 as well as a higher AUCI score of antigen‐stimulated IL‐6 (all P < 0.1). Tr14 might promote differentiated effects on the exercise‐induced immune response by (a) decreasing the inflammatory response of the innate immune system; and (b) augmenting the pro‐inflammatory cytokine response.</description><identifier>ISSN: 0905-7188</identifier><identifier>EISSN: 1600-0838</identifier><identifier>DOI: 10.1111/sms.12265</identifier><identifier>PMID: 24924232</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adult ; Anti-Inflammatory Agents - pharmacology ; Apoptosis - drug effects ; Area Under Curve ; C-Reactive Protein - metabolism ; Cells, Cultured ; complementary medicine ; Creatine Kinase - blood ; Cytokines ; Cytokines - blood ; Cytokines - drug effects ; Cytokines - metabolism ; Double-Blind Method ; Enterotoxins - immunology ; Epinephrine - blood ; Exercise - physiology ; Humans ; Hydro-Lyases - blood ; Inflammation - immunology ; Leukocyte Count ; Leukocytosis ; Lipopolysaccharides - immunology ; Lymphocyte Activation - drug effects ; Male ; Minerals - pharmacology ; muscle damage ; Norepinephrine - blood ; Pilot Projects ; Plant Extracts - pharmacology ; Prospective Studies ; sports ; Young Adult</subject><ispartof>Scandinavian journal of medicine & science in sports, 2015-08, Vol.25 (4), p.534-542</ispartof><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3965-d2c43a379fd330b59909ac9fb444fa361ecbac68fe53e78dec83a2d3988807493</citedby><cites>FETCH-LOGICAL-c3965-d2c43a379fd330b59909ac9fb444fa361ecbac68fe53e78dec83a2d3988807493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fsms.12265$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fsms.12265$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24924232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pilat, C.</creatorcontrib><creatorcontrib>Frech, T.</creatorcontrib><creatorcontrib>Wagner, A.</creatorcontrib><creatorcontrib>Krüger, K.</creatorcontrib><creatorcontrib>Hillebrecht, A.</creatorcontrib><creatorcontrib>Pons-Kühnemann, J.</creatorcontrib><creatorcontrib>Scheibelhut, C.</creatorcontrib><creatorcontrib>Bödeker, R.-H.</creatorcontrib><creatorcontrib>Mooren, F.-C.</creatorcontrib><title>Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT</title><title>Scandinavian journal of medicine & science in sports</title><addtitle>Scand J Med Sci Sports</addtitle><description>Traumeel (Tr14) is a natural, combination drug, which has been shown to modulate inflammation at the cytokine level. This study aimed to investigate potential effects of Tr14 on the exercise‐induced immune response. In a double‐blind, randomized, controlled trial, healthy, untrained male subjects received either Tr14 (n = 40) or placebo (n = 40) for 24 h after a strenuous experimental exercise trial on a bicycle (60 min at 80%VO2max). A range of antigen‐stimulated cytokines (in vitro), white blood cell count, lymphocyte activation and apoptosis markers, and indicators of muscle damage were assessed up to 24 h following exercise. The area under the curve with respect to the increase (AUCI) was compared between both groups. The Tr14 group showed a reduced exercise‐induced leukocytosis and neutrocytosis (P < 0.01 for both), a higher AUCI score of antigen‐stimulated IL‐1β and IL‐1α (absolute and per monocyte, all P < 0.05), a lower AUCI score of antigen‐stimulated GM‐CSF (P < 0.05) and by trend a lower AUCI score of antigen‐stimulated IL‐2 and IL‐4 as well as a higher AUCI score of antigen‐stimulated IL‐6 (all P < 0.1). Tr14 might promote differentiated effects on the exercise‐induced immune response by (a) decreasing the inflammatory response of the innate immune system; and (b) augmenting the pro‐inflammatory cytokine response.</description><subject>Adult</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Area Under Curve</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cells, Cultured</subject><subject>complementary medicine</subject><subject>Creatine Kinase - blood</subject><subject>Cytokines</subject><subject>Cytokines - blood</subject><subject>Cytokines - drug effects</subject><subject>Cytokines - metabolism</subject><subject>Double-Blind Method</subject><subject>Enterotoxins - immunology</subject><subject>Epinephrine - blood</subject><subject>Exercise - physiology</subject><subject>Humans</subject><subject>Hydro-Lyases - blood</subject><subject>Inflammation - immunology</subject><subject>Leukocyte Count</subject><subject>Leukocytosis</subject><subject>Lipopolysaccharides - immunology</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Male</subject><subject>Minerals - pharmacology</subject><subject>muscle damage</subject><subject>Norepinephrine - blood</subject><subject>Pilot Projects</subject><subject>Plant Extracts - pharmacology</subject><subject>Prospective Studies</subject><subject>sports</subject><subject>Young Adult</subject><issn>0905-7188</issn><issn>1600-0838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EotvCgT-AfIRDWn8lsblVq9IiSpHaUiQuluOMkcGOFzsRu_8ew7a9MZeZkZ73PTwIvaLkmNY5KbEcU8a69gla0Y6Qhkgun6IVUaRteirlATos5QchtFeifY4OmFBMMM5WaHu23YSU_fQdg3Ng54KTwwZPZl6yCdimOPj6-DThCKO3fgJcb9hCtr5A46dxsTBiP7lgYjRzyjvsY1wql6Fs0lTgHT7FY1qGAM0QagBfr29foGfOhAIv7_cR-vL-7HZ90Vx-Pv-wPr1sLFdd24zMCm54r9zIORlapYgyVrlBCOEM7yjYwdhOOmg59HIEK7lhI1dSStILxY_Qm33vJqdfC5RZR18shGAmSEvRtFMt7QWXvKJv96jNqZQMTm-yjybvNCX6r2hdRet_oiv7-r52GaqXR_LBbAVO9sBvH2D3_yZ98-nmobLZJ3yZYfuYMPmn7nret_rr1bn-xq7l3d3HK835H_YTmIs</recordid><startdate>201508</startdate><enddate>201508</enddate><creator>Pilat, C.</creator><creator>Frech, T.</creator><creator>Wagner, A.</creator><creator>Krüger, K.</creator><creator>Hillebrecht, A.</creator><creator>Pons-Kühnemann, J.</creator><creator>Scheibelhut, C.</creator><creator>Bödeker, R.-H.</creator><creator>Mooren, F.-C.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201508</creationdate><title>Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT</title><author>Pilat, C. ; Frech, T. ; Wagner, A. ; Krüger, K. ; Hillebrecht, A. ; Pons-Kühnemann, J. ; Scheibelhut, C. ; Bödeker, R.-H. ; Mooren, F.-C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3965-d2c43a379fd330b59909ac9fb444fa361ecbac68fe53e78dec83a2d3988807493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Area Under Curve</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cells, Cultured</topic><topic>complementary medicine</topic><topic>Creatine Kinase - blood</topic><topic>Cytokines</topic><topic>Cytokines - blood</topic><topic>Cytokines - drug effects</topic><topic>Cytokines - metabolism</topic><topic>Double-Blind Method</topic><topic>Enterotoxins - immunology</topic><topic>Epinephrine - blood</topic><topic>Exercise - physiology</topic><topic>Humans</topic><topic>Hydro-Lyases - blood</topic><topic>Inflammation - immunology</topic><topic>Leukocyte Count</topic><topic>Leukocytosis</topic><topic>Lipopolysaccharides - immunology</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Male</topic><topic>Minerals - pharmacology</topic><topic>muscle damage</topic><topic>Norepinephrine - blood</topic><topic>Pilot Projects</topic><topic>Plant Extracts - pharmacology</topic><topic>Prospective Studies</topic><topic>sports</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pilat, C.</creatorcontrib><creatorcontrib>Frech, T.</creatorcontrib><creatorcontrib>Wagner, A.</creatorcontrib><creatorcontrib>Krüger, K.</creatorcontrib><creatorcontrib>Hillebrecht, A.</creatorcontrib><creatorcontrib>Pons-Kühnemann, J.</creatorcontrib><creatorcontrib>Scheibelhut, C.</creatorcontrib><creatorcontrib>Bödeker, R.-H.</creatorcontrib><creatorcontrib>Mooren, F.-C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of medicine & science in sports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pilat, C.</au><au>Frech, T.</au><au>Wagner, A.</au><au>Krüger, K.</au><au>Hillebrecht, A.</au><au>Pons-Kühnemann, J.</au><au>Scheibelhut, C.</au><au>Bödeker, R.-H.</au><au>Mooren, F.-C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT</atitle><jtitle>Scandinavian journal of medicine & science in sports</jtitle><addtitle>Scand J Med Sci Sports</addtitle><date>2015-08</date><risdate>2015</risdate><volume>25</volume><issue>4</issue><spage>534</spage><epage>542</epage><pages>534-542</pages><issn>0905-7188</issn><eissn>1600-0838</eissn><abstract>Traumeel (Tr14) is a natural, combination drug, which has been shown to modulate inflammation at the cytokine level. This study aimed to investigate potential effects of Tr14 on the exercise‐induced immune response. In a double‐blind, randomized, controlled trial, healthy, untrained male subjects received either Tr14 (n = 40) or placebo (n = 40) for 24 h after a strenuous experimental exercise trial on a bicycle (60 min at 80%VO2max). A range of antigen‐stimulated cytokines (in vitro), white blood cell count, lymphocyte activation and apoptosis markers, and indicators of muscle damage were assessed up to 24 h following exercise. The area under the curve with respect to the increase (AUCI) was compared between both groups. The Tr14 group showed a reduced exercise‐induced leukocytosis and neutrocytosis (P < 0.01 for both), a higher AUCI score of antigen‐stimulated IL‐1β and IL‐1α (absolute and per monocyte, all P < 0.05), a lower AUCI score of antigen‐stimulated GM‐CSF (P < 0.05) and by trend a lower AUCI score of antigen‐stimulated IL‐2 and IL‐4 as well as a higher AUCI score of antigen‐stimulated IL‐6 (all P < 0.1). Tr14 might promote differentiated effects on the exercise‐induced immune response by (a) decreasing the inflammatory response of the innate immune system; and (b) augmenting the pro‐inflammatory cytokine response.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>24924232</pmid><doi>10.1111/sms.12265</doi><tpages>9</tpages></addata></record> |
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| ispartof | Scandinavian journal of medicine & science in sports, 2015-08, Vol.25 (4), p.534-542 |
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| subjects | Adult Anti-Inflammatory Agents - pharmacology Apoptosis - drug effects Area Under Curve C-Reactive Protein - metabolism Cells, Cultured complementary medicine Creatine Kinase - blood Cytokines Cytokines - blood Cytokines - drug effects Cytokines - metabolism Double-Blind Method Enterotoxins - immunology Epinephrine - blood Exercise - physiology Humans Hydro-Lyases - blood Inflammation - immunology Leukocyte Count Leukocytosis Lipopolysaccharides - immunology Lymphocyte Activation - drug effects Male Minerals - pharmacology muscle damage Norepinephrine - blood Pilot Projects Plant Extracts - pharmacology Prospective Studies sports Young Adult |
| title | Exploring effects of a natural combination medicine on exercise-induced inflammatory immune response: A double-blind RCT |
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