Toll-like receptor 4–induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large B-cell lymphoma
Abstract To evaluate the expression of tumor-associated macrophages (TAMs) and Toll-like receptor 4 (TLR4) in diffuse large B-cell lymphoma (DLBCL) and their correlation with patient clinical characteristics, we detected using immunohistochemistry in 81 specimens of patients with DLBCL. The correlat...
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| Veröffentlicht in: | Annals of diagnostic pathology 2015-08, Vol.19 (4), p.232-238 |
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| creator | Wang, Xiaofang, MD Li, Xiangli, MS Zhang, Xiaoying, MS Zang, Li, MS Yang, Hongliang, MS Zhao, Weipeng, MD Zhao, Haifeng, MD Li, Qian, MS Xia, Bing, MS Yu, Yong, MD Wang, Yafei, MD Zhao, Zhigang, MD Zhang, Yizhuo, PhD |
| description | Abstract To evaluate the expression of tumor-associated macrophages (TAMs) and Toll-like receptor 4 (TLR4) in diffuse large B-cell lymphoma (DLBCL) and their correlation with patient clinical characteristics, we detected using immunohistochemistry in 81 specimens of patients with DLBCL. The correlation between protein expression levels and clinical parameters, as well as the association between CD68 and TLR4 were analyzed. The number of CD68 TAMs was closely related to β2 -microglobulin ( P = .028 and P < .05), whereas there was no significant correlation between the number of CD68 TAMs and other clinical factors. Toll-like receptor 4 was related to tumor size and peripheral blood lymphocyte to monocyte ratio. The Spearman correlation coefficient indicated a significant positive correlation between CD68 TAMs and TLR4 expression ( r = 0.240; P = .038, P = .05). These results, on one hand, indicated that TLR4-induced inflammatory responses may affect TAM infiltration and accumulation, and that TAMs and TLR4 may interact to play important roles in DLBCL microenvironment regulating the tumor growth, but, on the other hand demonstrated that both of TAMs and TLR4 had not only one side on DLBCL growth. |
| doi_str_mv | 10.1016/j.anndiagpath.2015.04.008 |
| format | Article |
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The correlation between protein expression levels and clinical parameters, as well as the association between CD68 and TLR4 were analyzed. The number of CD68 TAMs was closely related to β2 -microglobulin ( P = .028 and P < .05), whereas there was no significant correlation between the number of CD68 TAMs and other clinical factors. Toll-like receptor 4 was related to tumor size and peripheral blood lymphocyte to monocyte ratio. The Spearman correlation coefficient indicated a significant positive correlation between CD68 TAMs and TLR4 expression ( r = 0.240; P = .038, P = .05). These results, on one hand, indicated that TLR4-induced inflammatory responses may affect TAM infiltration and accumulation, and that TAMs and TLR4 may interact to play important roles in DLBCL microenvironment regulating the tumor growth, but, on the other hand demonstrated that both of TAMs and TLR4 had not only one side on DLBCL growth.</description><identifier>ISSN: 1092-9134</identifier><identifier>EISSN: 1532-8198</identifier><identifier>DOI: 10.1016/j.anndiagpath.2015.04.008</identifier><identifier>PMID: 26071054</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigens, CD - immunology ; Antigens, CD - metabolism ; Antigens, Differentiation, Myelomonocytic - immunology ; Antigens, Differentiation, Myelomonocytic - metabolism ; beta 2-Microglobulin - biosynthesis ; beta 2-Microglobulin - immunology ; Clinical parameters ; Diffuse large B-cell lymphoma (DLBCL) ; Female ; Germinal Center - immunology ; Germinal Center - metabolism ; Humans ; Immunohistochemistry ; Immunohistochemistry - methods ; Lymphoma, Large B-Cell, Diffuse - immunology ; Lymphoma, Large B-Cell, Diffuse - metabolism ; Lymphoma, Large B-Cell, Diffuse - pathology ; Macrophages - immunology ; Macrophages - pathology ; Male ; Middle Aged ; Pathology ; Prognosis ; Retrospective Studies ; Toll-like receptor 4 (TLR4) ; Toll-Like Receptor 4 - immunology ; Toll-Like Receptor 4 - metabolism ; Treatment Outcome ; Tumor-associated macrophages (TAMs)</subject><ispartof>Annals of diagnostic pathology, 2015-08, Vol.19 (4), p.232-238</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-3bbe0864b0fbf2b876d28ada366efd883b415271096ef8a35eff1c8d0b1c89313</citedby><cites>FETCH-LOGICAL-c502t-3bbe0864b0fbf2b876d28ada366efd883b415271096ef8a35eff1c8d0b1c89313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anndiagpath.2015.04.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26071054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiaofang, MD</creatorcontrib><creatorcontrib>Li, Xiangli, MS</creatorcontrib><creatorcontrib>Zhang, Xiaoying, MS</creatorcontrib><creatorcontrib>Zang, Li, MS</creatorcontrib><creatorcontrib>Yang, Hongliang, MS</creatorcontrib><creatorcontrib>Zhao, Weipeng, MD</creatorcontrib><creatorcontrib>Zhao, Haifeng, MD</creatorcontrib><creatorcontrib>Li, Qian, MS</creatorcontrib><creatorcontrib>Xia, Bing, MS</creatorcontrib><creatorcontrib>Yu, Yong, MD</creatorcontrib><creatorcontrib>Wang, Yafei, MD</creatorcontrib><creatorcontrib>Zhao, Zhigang, MD</creatorcontrib><creatorcontrib>Zhang, Yizhuo, PhD</creatorcontrib><title>Toll-like receptor 4–induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large B-cell lymphoma</title><title>Annals of diagnostic pathology</title><addtitle>Ann Diagn Pathol</addtitle><description>Abstract To evaluate the expression of tumor-associated macrophages (TAMs) and Toll-like receptor 4 (TLR4) in diffuse large B-cell lymphoma (DLBCL) and their correlation with patient clinical characteristics, we detected using immunohistochemistry in 81 specimens of patients with DLBCL. The correlation between protein expression levels and clinical parameters, as well as the association between CD68 and TLR4 were analyzed. The number of CD68 TAMs was closely related to β2 -microglobulin ( P = .028 and P < .05), whereas there was no significant correlation between the number of CD68 TAMs and other clinical factors. Toll-like receptor 4 was related to tumor size and peripheral blood lymphocyte to monocyte ratio. The Spearman correlation coefficient indicated a significant positive correlation between CD68 TAMs and TLR4 expression ( r = 0.240; P = .038, P = .05). These results, on one hand, indicated that TLR4-induced inflammatory responses may affect TAM infiltration and accumulation, and that TAMs and TLR4 may interact to play important roles in DLBCL microenvironment regulating the tumor growth, but, on the other hand demonstrated that both of TAMs and TLR4 had not only one side on DLBCL growth.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD - metabolism</subject><subject>Antigens, Differentiation, Myelomonocytic - immunology</subject><subject>Antigens, Differentiation, Myelomonocytic - metabolism</subject><subject>beta 2-Microglobulin - biosynthesis</subject><subject>beta 2-Microglobulin - immunology</subject><subject>Clinical parameters</subject><subject>Diffuse large B-cell lymphoma (DLBCL)</subject><subject>Female</subject><subject>Germinal Center - immunology</subject><subject>Germinal Center - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunohistochemistry - methods</subject><subject>Lymphoma, Large B-Cell, Diffuse - immunology</subject><subject>Lymphoma, Large B-Cell, Diffuse - metabolism</subject><subject>Lymphoma, Large B-Cell, Diffuse - pathology</subject><subject>Macrophages - immunology</subject><subject>Macrophages - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Toll-like receptor 4 (TLR4)</subject><subject>Toll-Like Receptor 4 - immunology</subject><subject>Toll-Like Receptor 4 - metabolism</subject><subject>Treatment Outcome</subject><subject>Tumor-associated macrophages (TAMs)</subject><issn>1092-9134</issn><issn>1532-8198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUkuO1DAQjRCIGQaugMyOTYKdxOlkgwQtftJILBjWlmOXu93j2MF2QL3jDtxjDjUnoUIPCLFi47JL771y1auieMZoxSjrXhwq6b22cjfLvK9qynhF24rS_l5xznhTlz0b-vt4p0NdDqxpz4pHKR0oZazlm4fFWd3RDaO8PS9uroJzpbPXQCIomHOIpL39_sN6vSjQxHrj5DRJzB8RkebgEySigs_RjksGkgPJewzLFGIpUwrKyozMSaoY5r3cIdyEiBI2eCL9L03rcjwlrCfYhQWfE_lm855oa8ySgDgZd0BelwqcI-44zfswycfFAyNdgid38aL4_PbN1fZ9efnx3Yftq8tScVrnshlHoH3XjtSMph77TafrXmrZdB0Y3ffN2DJe4wgGfPey4WAMU72mI55Dw5qL4vlJd47hywIpi8mm9SfSQ1iSYN3A2aalvEHocIJiuylFMGKOdpLxKBgVq13iIP6yS6x2CdoKtAu5T-_KLOME-g_ztz8I2J4AgM1-tRBFUjgrdMaiXVnoYP-rzMt_VJSz3irpruEI6RCW6HGagolUCyo-rXuzrg3jFOn10PwEvATHsg</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Wang, Xiaofang, MD</creator><creator>Li, Xiangli, MS</creator><creator>Zhang, Xiaoying, MS</creator><creator>Zang, Li, MS</creator><creator>Yang, Hongliang, MS</creator><creator>Zhao, Weipeng, MD</creator><creator>Zhao, Haifeng, MD</creator><creator>Li, Qian, MS</creator><creator>Xia, Bing, MS</creator><creator>Yu, Yong, MD</creator><creator>Wang, Yafei, MD</creator><creator>Zhao, Zhigang, MD</creator><creator>Zhang, Yizhuo, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>Toll-like receptor 4–induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large B-cell lymphoma</title><author>Wang, Xiaofang, MD ; Li, Xiangli, MS ; Zhang, Xiaoying, MS ; Zang, Li, MS ; Yang, Hongliang, MS ; Zhao, Weipeng, MD ; Zhao, Haifeng, MD ; Li, Qian, MS ; Xia, Bing, MS ; Yu, Yong, MD ; Wang, Yafei, MD ; Zhao, Zhigang, MD ; Zhang, Yizhuo, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-3bbe0864b0fbf2b876d28ada366efd883b415271096ef8a35eff1c8d0b1c89313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, CD - metabolism</topic><topic>Antigens, Differentiation, Myelomonocytic - immunology</topic><topic>Antigens, Differentiation, Myelomonocytic - metabolism</topic><topic>beta 2-Microglobulin - biosynthesis</topic><topic>beta 2-Microglobulin - immunology</topic><topic>Clinical parameters</topic><topic>Diffuse large B-cell lymphoma (DLBCL)</topic><topic>Female</topic><topic>Germinal Center - immunology</topic><topic>Germinal Center - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunohistochemistry - methods</topic><topic>Lymphoma, Large B-Cell, Diffuse - immunology</topic><topic>Lymphoma, Large B-Cell, Diffuse - metabolism</topic><topic>Lymphoma, Large B-Cell, Diffuse - pathology</topic><topic>Macrophages - immunology</topic><topic>Macrophages - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Toll-like receptor 4 (TLR4)</topic><topic>Toll-Like Receptor 4 - immunology</topic><topic>Toll-Like Receptor 4 - metabolism</topic><topic>Treatment Outcome</topic><topic>Tumor-associated macrophages (TAMs)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiaofang, MD</creatorcontrib><creatorcontrib>Li, Xiangli, MS</creatorcontrib><creatorcontrib>Zhang, Xiaoying, MS</creatorcontrib><creatorcontrib>Zang, Li, MS</creatorcontrib><creatorcontrib>Yang, Hongliang, MS</creatorcontrib><creatorcontrib>Zhao, Weipeng, MD</creatorcontrib><creatorcontrib>Zhao, Haifeng, MD</creatorcontrib><creatorcontrib>Li, Qian, MS</creatorcontrib><creatorcontrib>Xia, Bing, MS</creatorcontrib><creatorcontrib>Yu, Yong, MD</creatorcontrib><creatorcontrib>Wang, Yafei, MD</creatorcontrib><creatorcontrib>Zhao, Zhigang, MD</creatorcontrib><creatorcontrib>Zhang, Yizhuo, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of diagnostic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiaofang, MD</au><au>Li, Xiangli, MS</au><au>Zhang, Xiaoying, MS</au><au>Zang, Li, MS</au><au>Yang, Hongliang, MS</au><au>Zhao, Weipeng, MD</au><au>Zhao, Haifeng, MD</au><au>Li, Qian, MS</au><au>Xia, Bing, MS</au><au>Yu, Yong, MD</au><au>Wang, Yafei, MD</au><au>Zhao, Zhigang, MD</au><au>Zhang, Yizhuo, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toll-like receptor 4–induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large B-cell lymphoma</atitle><jtitle>Annals of diagnostic pathology</jtitle><addtitle>Ann Diagn Pathol</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>19</volume><issue>4</issue><spage>232</spage><epage>238</epage><pages>232-238</pages><issn>1092-9134</issn><eissn>1532-8198</eissn><abstract>Abstract To evaluate the expression of tumor-associated macrophages (TAMs) and Toll-like receptor 4 (TLR4) in diffuse large B-cell lymphoma (DLBCL) and their correlation with patient clinical characteristics, we detected using immunohistochemistry in 81 specimens of patients with DLBCL. The correlation between protein expression levels and clinical parameters, as well as the association between CD68 and TLR4 were analyzed. The number of CD68 TAMs was closely related to β2 -microglobulin ( P = .028 and P < .05), whereas there was no significant correlation between the number of CD68 TAMs and other clinical factors. Toll-like receptor 4 was related to tumor size and peripheral blood lymphocyte to monocyte ratio. The Spearman correlation coefficient indicated a significant positive correlation between CD68 TAMs and TLR4 expression ( r = 0.240; P = .038, P = .05). These results, on one hand, indicated that TLR4-induced inflammatory responses may affect TAM infiltration and accumulation, and that TAMs and TLR4 may interact to play important roles in DLBCL microenvironment regulating the tumor growth, but, on the other hand demonstrated that both of TAMs and TLR4 had not only one side on DLBCL growth.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26071054</pmid><doi>10.1016/j.anndiagpath.2015.04.008</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Annals of diagnostic pathology, 2015-08, Vol.19 (4), p.232-238 |
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| subjects | Adult Aged Aged, 80 and over Antigens, CD - immunology Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - immunology Antigens, Differentiation, Myelomonocytic - metabolism beta 2-Microglobulin - biosynthesis beta 2-Microglobulin - immunology Clinical parameters Diffuse large B-cell lymphoma (DLBCL) Female Germinal Center - immunology Germinal Center - metabolism Humans Immunohistochemistry Immunohistochemistry - methods Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Macrophages - immunology Macrophages - pathology Male Middle Aged Pathology Prognosis Retrospective Studies Toll-like receptor 4 (TLR4) Toll-Like Receptor 4 - immunology Toll-Like Receptor 4 - metabolism Treatment Outcome Tumor-associated macrophages (TAMs) |
| title | Toll-like receptor 4–induced inflammatory responses contribute to the tumor-associated macrophages formation and infiltration in patients with diffuse large B-cell lymphoma |
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