Mucinous spindle and tubular renal cell carcinoma: analysis of chromosomal aberration pattern of low-grade, high-grade, and overlapping morphologic variant with papillary renal cell carcinoma
Abstract The chromosomal numerical aberration pattern in mucinous tubular and spindle renal cell carcinoma (MTSRCC) is referred to as variable with frequent gains and losses. The objectives of this study are to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of th...
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| Veröffentlicht in: | Annals of diagnostic pathology 2015-08, Vol.19 (4), p.226-231 |
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| creator | Peckova, Kvetoslava, MD Martinek, Petr, MSc Sperga, Maris, MD Montiel, Delia Perez, MD Daum, Ondrej, MD, PhD Rotterova, Pavla, MD, PhD Kalusová, Kristýna, MD Hora, Milan, MD, PhD Pivovarcikova, Kristýna, MD Rychly, Boris, MD Vranic, Semir, MD, PhD Davidson, Whitney, MD Vodicka, Josef, MD, PhD Dubová, Magdaléna, MD Michal, Michal, MD Hes, Ondrej, MD, PhD |
| description | Abstract The chromosomal numerical aberration pattern in mucinous tubular and spindle renal cell carcinoma (MTSRCC) is referred to as variable with frequent gains and losses. The objectives of this study are to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of the cases and relate these findings to the morphologic variants of MTSRCC. Fifty-four MTSRCCs with uniform morphologic pattern were selected (of 133 MTSRCCs available in our registry) and divided into 3 groups: classic low-grade MTSRCC (Fuhrman nucleolar International Society of Urological Pathology grade 2), high-grade MTSRCC (grade 3), and overlapping MTSRCC with papillary renal cell carcinoma (RCC) morphology. Array comparative genomic hybridization analysis was applied to 16 cases in which DNA was well preserved. Four analyzable classic low-grade MTSRCCs showed multiple losses affecting chromosomes 1, 4, 8, 9, 14, 15, and 22. No chromosomal gains were found. Four analyzable cases of MTSRCC showing overlapping morphology with PRCC displayed a more variable pattern including normal chromosomal status; losses of chromosomes 1, 6, 8, 9, 14, 15, and 22; and gains of 3, 7, 16, and 17. The group of 4 high-grade MTSRCCs exhibited a more uniform chromosomal aberration pattern with losses of chromosomes 1, 4, 6, 8, 9, 13, 14, 15, and 22 and without any gains detected. (1) MTSRCC, both low-grade and high-grade, shows chromosomal losses (including 1, 4, 6, 8, 9, 13, 14, 15, and 22) in all analyzable cases; this seems to be the most frequent chromosomal numerical aberration in this type of RCC. (2) Cases with overlapping morphologic features (MTSRCC and PRCC) showed a more variable pattern with multiple losses and gains, including gains of chromosomes 7 and 17 (2 cases). This result is in line with previously published morphologic and immunohistochemical studies that describe the broad morphologic spectrum of MTSRCC, with changes resembling papillary RCC. (3) The diagnosis of MTSRCC in tumors with overlapping morphology (MTSRCC and PRCC) showing gains of both chromosomes 7 and 17 remains questionable. Based on our findings, we recommend that such tumors should not be classified as MTSRCC but rather as PRCC. |
| doi_str_mv | 10.1016/j.anndiagpath.2015.04.004 |
| format | Article |
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The objectives of this study are to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of the cases and relate these findings to the morphologic variants of MTSRCC. Fifty-four MTSRCCs with uniform morphologic pattern were selected (of 133 MTSRCCs available in our registry) and divided into 3 groups: classic low-grade MTSRCC (Fuhrman nucleolar International Society of Urological Pathology grade 2), high-grade MTSRCC (grade 3), and overlapping MTSRCC with papillary renal cell carcinoma (RCC) morphology. Array comparative genomic hybridization analysis was applied to 16 cases in which DNA was well preserved. Four analyzable classic low-grade MTSRCCs showed multiple losses affecting chromosomes 1, 4, 8, 9, 14, 15, and 22. No chromosomal gains were found. Four analyzable cases of MTSRCC showing overlapping morphology with PRCC displayed a more variable pattern including normal chromosomal status; losses of chromosomes 1, 6, 8, 9, 14, 15, and 22; and gains of 3, 7, 16, and 17. The group of 4 high-grade MTSRCCs exhibited a more uniform chromosomal aberration pattern with losses of chromosomes 1, 4, 6, 8, 9, 13, 14, 15, and 22 and without any gains detected. (1) MTSRCC, both low-grade and high-grade, shows chromosomal losses (including 1, 4, 6, 8, 9, 13, 14, 15, and 22) in all analyzable cases; this seems to be the most frequent chromosomal numerical aberration in this type of RCC. (2) Cases with overlapping morphologic features (MTSRCC and PRCC) showed a more variable pattern with multiple losses and gains, including gains of chromosomes 7 and 17 (2 cases). This result is in line with previously published morphologic and immunohistochemical studies that describe the broad morphologic spectrum of MTSRCC, with changes resembling papillary RCC. (3) The diagnosis of MTSRCC in tumors with overlapping morphology (MTSRCC and PRCC) showing gains of both chromosomes 7 and 17 remains questionable. Based on our findings, we recommend that such tumors should not be classified as MTSRCC but rather as PRCC.</description><identifier>ISSN: 1092-9134</identifier><identifier>EISSN: 1532-8198</identifier><identifier>DOI: 10.1016/j.anndiagpath.2015.04.004</identifier><identifier>PMID: 26009022</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>aCGH ; Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Adenocarcinoma, Mucinous - genetics ; Adenocarcinoma, Mucinous - pathology ; Aged ; Aged, 80 and over ; Aneuploidy ; Carcinoma, Papillary - genetics ; Carcinoma, Papillary - pathology ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - pathology ; Chromosomal aberration ; Chromosome Aberrations ; Chromosomes, Human, Pair 17 ; Chromosomes, Human, Pair 7 ; Comparative Genomic Hybridization - methods ; Diagnosis, Differential ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Kidney ; Kidney Neoplasms - genetics ; Kidney Neoplasms - pathology ; Male ; Middle Aged ; Mucinous spindle and tubular cell carcinoma ; Neoplasm Grading ; Pathology</subject><ispartof>Annals of diagnostic pathology, 2015-08, Vol.19 (4), p.226-231</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c502t-42ff1c712ae79691e0fbf2c133e3493b9f2c39ebc42e12d33ca9d659affb2d083</citedby><cites>FETCH-LOGICAL-c502t-42ff1c712ae79691e0fbf2c133e3493b9f2c39ebc42e12d33ca9d659affb2d083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.anndiagpath.2015.04.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26009022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peckova, Kvetoslava, MD</creatorcontrib><creatorcontrib>Martinek, Petr, MSc</creatorcontrib><creatorcontrib>Sperga, Maris, MD</creatorcontrib><creatorcontrib>Montiel, Delia Perez, MD</creatorcontrib><creatorcontrib>Daum, Ondrej, MD, PhD</creatorcontrib><creatorcontrib>Rotterova, Pavla, MD, PhD</creatorcontrib><creatorcontrib>Kalusová, Kristýna, MD</creatorcontrib><creatorcontrib>Hora, Milan, MD, PhD</creatorcontrib><creatorcontrib>Pivovarcikova, Kristýna, MD</creatorcontrib><creatorcontrib>Rychly, Boris, MD</creatorcontrib><creatorcontrib>Vranic, Semir, MD, PhD</creatorcontrib><creatorcontrib>Davidson, Whitney, MD</creatorcontrib><creatorcontrib>Vodicka, Josef, MD, PhD</creatorcontrib><creatorcontrib>Dubová, Magdaléna, MD</creatorcontrib><creatorcontrib>Michal, Michal, MD</creatorcontrib><creatorcontrib>Hes, Ondrej, MD, PhD</creatorcontrib><title>Mucinous spindle and tubular renal cell carcinoma: analysis of chromosomal aberration pattern of low-grade, high-grade, and overlapping morphologic variant with papillary renal cell carcinoma</title><title>Annals of diagnostic pathology</title><addtitle>Ann Diagn Pathol</addtitle><description>Abstract The chromosomal numerical aberration pattern in mucinous tubular and spindle renal cell carcinoma (MTSRCC) is referred to as variable with frequent gains and losses. The objectives of this study are to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of the cases and relate these findings to the morphologic variants of MTSRCC. Fifty-four MTSRCCs with uniform morphologic pattern were selected (of 133 MTSRCCs available in our registry) and divided into 3 groups: classic low-grade MTSRCC (Fuhrman nucleolar International Society of Urological Pathology grade 2), high-grade MTSRCC (grade 3), and overlapping MTSRCC with papillary renal cell carcinoma (RCC) morphology. Array comparative genomic hybridization analysis was applied to 16 cases in which DNA was well preserved. Four analyzable classic low-grade MTSRCCs showed multiple losses affecting chromosomes 1, 4, 8, 9, 14, 15, and 22. No chromosomal gains were found. Four analyzable cases of MTSRCC showing overlapping morphology with PRCC displayed a more variable pattern including normal chromosomal status; losses of chromosomes 1, 6, 8, 9, 14, 15, and 22; and gains of 3, 7, 16, and 17. The group of 4 high-grade MTSRCCs exhibited a more uniform chromosomal aberration pattern with losses of chromosomes 1, 4, 6, 8, 9, 13, 14, 15, and 22 and without any gains detected. (1) MTSRCC, both low-grade and high-grade, shows chromosomal losses (including 1, 4, 6, 8, 9, 13, 14, 15, and 22) in all analyzable cases; this seems to be the most frequent chromosomal numerical aberration in this type of RCC. (2) Cases with overlapping morphologic features (MTSRCC and PRCC) showed a more variable pattern with multiple losses and gains, including gains of chromosomes 7 and 17 (2 cases). This result is in line with previously published morphologic and immunohistochemical studies that describe the broad morphologic spectrum of MTSRCC, with changes resembling papillary RCC. (3) The diagnosis of MTSRCC in tumors with overlapping morphology (MTSRCC and PRCC) showing gains of both chromosomes 7 and 17 remains questionable. Based on our findings, we recommend that such tumors should not be classified as MTSRCC but rather as PRCC.</description><subject>aCGH</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma, Mucinous - genetics</subject><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aneuploidy</subject><subject>Carcinoma, Papillary - genetics</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Chromosomal aberration</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 17</subject><subject>Chromosomes, Human, Pair 7</subject><subject>Comparative Genomic Hybridization - methods</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Kidney</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucinous spindle and tubular cell carcinoma</subject><subject>Neoplasm Grading</subject><subject>Pathology</subject><issn>1092-9134</issn><issn>1532-8198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk2P0zAQjRCIXRb-AjI3DqSM7aStOSChii9pEQfgbE2cSePi2MFOuuqv46_hqLsIIQ5c7LH1Zt6beVMUzzisOPD1y8MKvW8t7kec-pUAXq-gWgFU94pLXktRbrna3s8xKFEqLquL4lFKBwDOq3rzsLgQawAFQlwWPz_NxvowJ5ZG61tHDH3LprmZHUYWyaNjhlw-MC7AAV9lBLpTsomFjpk-hiGk_O8YNhQjTjZ4loVNFP2CcOGm3Eds6QXr7b6_ixeacKTocMzEezaEOPbBhb017IjRop_YjZ36XGq0Los5_VPN4-JBhy7Rk9v7qvj27u3X3Yfy-vP7j7s316WpQUxlJbqOmw0XSBu1VpygazphuJQkKyUblR9SUWMqQVy0UhpU7bpW2HWNaGErr4rn57pjDD9mSpMebFqkoKc8Pc3XquYbmRkyVJ2hJoaUInV6jHbIDWgOevFPH_Qf_unFPw2Vzv7l3Ke3NHMzUPs7886wDNidAZSbPVqKOhlL3lBrI5lJt8H-F83rv6oYZ7016L7TidIhzDGPOnelk9CgvyyLtOwRrwFgI7fyF6eOzI8</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Peckova, Kvetoslava, MD</creator><creator>Martinek, Petr, MSc</creator><creator>Sperga, Maris, MD</creator><creator>Montiel, Delia Perez, MD</creator><creator>Daum, Ondrej, MD, PhD</creator><creator>Rotterova, Pavla, MD, PhD</creator><creator>Kalusová, Kristýna, MD</creator><creator>Hora, Milan, MD, PhD</creator><creator>Pivovarcikova, Kristýna, MD</creator><creator>Rychly, Boris, MD</creator><creator>Vranic, Semir, MD, PhD</creator><creator>Davidson, Whitney, MD</creator><creator>Vodicka, Josef, MD, PhD</creator><creator>Dubová, Magdaléna, MD</creator><creator>Michal, Michal, MD</creator><creator>Hes, Ondrej, MD, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150801</creationdate><title>Mucinous spindle and tubular renal cell carcinoma: analysis of chromosomal aberration pattern of low-grade, high-grade, and overlapping morphologic variant with papillary renal cell carcinoma</title><author>Peckova, Kvetoslava, MD ; Martinek, Petr, MSc ; Sperga, Maris, MD ; Montiel, Delia Perez, MD ; Daum, Ondrej, MD, PhD ; Rotterova, Pavla, MD, PhD ; Kalusová, Kristýna, MD ; Hora, Milan, MD, PhD ; Pivovarcikova, Kristýna, MD ; Rychly, Boris, MD ; Vranic, Semir, MD, PhD ; Davidson, Whitney, MD ; Vodicka, Josef, MD, PhD ; Dubová, Magdaléna, MD ; Michal, Michal, MD ; Hes, Ondrej, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c502t-42ff1c712ae79691e0fbf2c133e3493b9f2c39ebc42e12d33ca9d659affb2d083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>aCGH</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma, Mucinous - genetics</topic><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aneuploidy</topic><topic>Carcinoma, Papillary - genetics</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Chromosomal aberration</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 17</topic><topic>Chromosomes, Human, Pair 7</topic><topic>Comparative Genomic Hybridization - methods</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Kidney</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucinous spindle and tubular cell carcinoma</topic><topic>Neoplasm Grading</topic><topic>Pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peckova, Kvetoslava, MD</creatorcontrib><creatorcontrib>Martinek, Petr, MSc</creatorcontrib><creatorcontrib>Sperga, Maris, MD</creatorcontrib><creatorcontrib>Montiel, Delia Perez, MD</creatorcontrib><creatorcontrib>Daum, Ondrej, MD, PhD</creatorcontrib><creatorcontrib>Rotterova, Pavla, MD, PhD</creatorcontrib><creatorcontrib>Kalusová, Kristýna, MD</creatorcontrib><creatorcontrib>Hora, Milan, MD, PhD</creatorcontrib><creatorcontrib>Pivovarcikova, Kristýna, MD</creatorcontrib><creatorcontrib>Rychly, Boris, MD</creatorcontrib><creatorcontrib>Vranic, Semir, MD, PhD</creatorcontrib><creatorcontrib>Davidson, Whitney, MD</creatorcontrib><creatorcontrib>Vodicka, Josef, MD, PhD</creatorcontrib><creatorcontrib>Dubová, Magdaléna, MD</creatorcontrib><creatorcontrib>Michal, Michal, MD</creatorcontrib><creatorcontrib>Hes, Ondrej, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of diagnostic pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peckova, Kvetoslava, MD</au><au>Martinek, Petr, MSc</au><au>Sperga, Maris, MD</au><au>Montiel, Delia Perez, MD</au><au>Daum, Ondrej, MD, PhD</au><au>Rotterova, Pavla, MD, PhD</au><au>Kalusová, Kristýna, MD</au><au>Hora, Milan, MD, PhD</au><au>Pivovarcikova, Kristýna, MD</au><au>Rychly, Boris, MD</au><au>Vranic, Semir, MD, PhD</au><au>Davidson, Whitney, MD</au><au>Vodicka, Josef, MD, PhD</au><au>Dubová, Magdaléna, MD</au><au>Michal, Michal, MD</au><au>Hes, Ondrej, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mucinous spindle and tubular renal cell carcinoma: analysis of chromosomal aberration pattern of low-grade, high-grade, and overlapping morphologic variant with papillary renal cell carcinoma</atitle><jtitle>Annals of diagnostic pathology</jtitle><addtitle>Ann Diagn Pathol</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>19</volume><issue>4</issue><spage>226</spage><epage>231</epage><pages>226-231</pages><issn>1092-9134</issn><eissn>1532-8198</eissn><abstract>Abstract The chromosomal numerical aberration pattern in mucinous tubular and spindle renal cell carcinoma (MTSRCC) is referred to as variable with frequent gains and losses. The objectives of this study are to map the spectrum of chromosomal aberrations (extent and location) in a large cohort of the cases and relate these findings to the morphologic variants of MTSRCC. Fifty-four MTSRCCs with uniform morphologic pattern were selected (of 133 MTSRCCs available in our registry) and divided into 3 groups: classic low-grade MTSRCC (Fuhrman nucleolar International Society of Urological Pathology grade 2), high-grade MTSRCC (grade 3), and overlapping MTSRCC with papillary renal cell carcinoma (RCC) morphology. Array comparative genomic hybridization analysis was applied to 16 cases in which DNA was well preserved. Four analyzable classic low-grade MTSRCCs showed multiple losses affecting chromosomes 1, 4, 8, 9, 14, 15, and 22. No chromosomal gains were found. Four analyzable cases of MTSRCC showing overlapping morphology with PRCC displayed a more variable pattern including normal chromosomal status; losses of chromosomes 1, 6, 8, 9, 14, 15, and 22; and gains of 3, 7, 16, and 17. The group of 4 high-grade MTSRCCs exhibited a more uniform chromosomal aberration pattern with losses of chromosomes 1, 4, 6, 8, 9, 13, 14, 15, and 22 and without any gains detected. (1) MTSRCC, both low-grade and high-grade, shows chromosomal losses (including 1, 4, 6, 8, 9, 13, 14, 15, and 22) in all analyzable cases; this seems to be the most frequent chromosomal numerical aberration in this type of RCC. (2) Cases with overlapping morphologic features (MTSRCC and PRCC) showed a more variable pattern with multiple losses and gains, including gains of chromosomes 7 and 17 (2 cases). This result is in line with previously published morphologic and immunohistochemical studies that describe the broad morphologic spectrum of MTSRCC, with changes resembling papillary RCC. (3) The diagnosis of MTSRCC in tumors with overlapping morphology (MTSRCC and PRCC) showing gains of both chromosomes 7 and 17 remains questionable. Based on our findings, we recommend that such tumors should not be classified as MTSRCC but rather as PRCC.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26009022</pmid><doi>10.1016/j.anndiagpath.2015.04.004</doi><tpages>6</tpages></addata></record> |
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| subjects | aCGH Adenocarcinoma - genetics Adenocarcinoma - pathology Adenocarcinoma, Mucinous - genetics Adenocarcinoma, Mucinous - pathology Aged Aged, 80 and over Aneuploidy Carcinoma, Papillary - genetics Carcinoma, Papillary - pathology Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Chromosomal aberration Chromosome Aberrations Chromosomes, Human, Pair 17 Chromosomes, Human, Pair 7 Comparative Genomic Hybridization - methods Diagnosis, Differential Female Humans In Situ Hybridization, Fluorescence Kidney Kidney Neoplasms - genetics Kidney Neoplasms - pathology Male Middle Aged Mucinous spindle and tubular cell carcinoma Neoplasm Grading Pathology |
| title | Mucinous spindle and tubular renal cell carcinoma: analysis of chromosomal aberration pattern of low-grade, high-grade, and overlapping morphologic variant with papillary renal cell carcinoma |
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