Alterations of calcium homoeostasis in cultured rat astrocytes evoked by bioactive sphingolipids

Aim In the brain, alterations in sphingolipid metabolism contribute to several neurological disorders; however, their effect on astrocytes is largely unknown. Here, we identified bioactive sphingolipids that affect intracellular free calcium concentration ([Ca2+]i), mobility of peptidergic secretory...

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Veröffentlicht in:	Acta Physiologica 2014-09, Vol.212 (1), p.49-61
Hauptverfasser:	Stenovec, M., Trkov, S., Kreft, M., Zorec, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocytes Astrocytes - drug effects Astrocytes - metabolism Calcium Calcium - metabolism Calcium Signaling - drug effects Calcium Signaling - physiology Cells, Cultured Cytoplasmic Vesicles - drug effects Fingolimod Hydrochloride FTY720 Homeostasis - drug effects Homeostasis - physiology Microscopy, Confocal phospholipase C Propylene Glycols - pharmacology Rats Rats, Wistar Sphingolipids - pharmacology sphingosine Sphingosine - analogs & derivatives Sphingosine - pharmacology vesicle traffic
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