Methamphetamine induces DNA damage in specific regions of the female rat brain
Summary Methamphetamine (METH) is a highly addictive psychostimulant that has been shown to produce neurotoxicity. Methamphetamine increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain. In this...
Gespeichert in:
| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 2015-06, Vol.42 (6), p.570-575 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 575 |
|---|---|
| container_issue | 6 |
| container_start_page | 570 |
| container_title | Clinical and experimental pharmacology & physiology |
| container_volume | 42 |
| creator | Johnson, Zane Venters, Jace Guarraci, Fay A Zewail-Foote, Maha |
| description | Summary
Methamphetamine (METH) is a highly addictive psychostimulant that has been shown to produce neurotoxicity. Methamphetamine increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain. In this study, we examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions. Rats treated with multiple doses of METH (10 mg/kg × 4) showed significant levels of DNA damage in the nucleus accumbens and striatum, both dopamine‐rich areas. In contrast, a single dose of METH did not lead to significant levels of DNA damage in any of the dopamine‐rich brain regions that were tested. Overall, the results of our study demonstrate that METH produces greater oxidative DNA damage in brain areas that receive greater dopamine innervation. |
| doi_str_mv | 10.1111/1440-1681.12404 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1694986014</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1694986014</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4424-178fbfb143ddeb5614fa49d009b57aa5e3d7ce43a7aae01bb2169ecc2569ed7f3</originalsourceid><addsrcrecordid>eNqFkM1PGzEQxS1UVNLQc2-VpV56WbDX9npzTNOEIiDkwMfR8nrHxOl-BHtXhf8ebwM5cGEuMx793hvrIfSNkhMa65RyThKa5fSEppzwAzTabz6hEWFEJDSX5Ah9CWFDCBEkY5_RUSryTOaMjdDyCrq1rrdr6HTtGsCuKXsDAf9eTnGpa_0wrHDYgnHWGezhwbVNwK3F3RqwhVpXgL3ucOG1a47RodVVgK-vfYxuF_Ob2Z_k8vrsfDa9TAznKU-ozG1hC8pZWUIhMsqt5pOSkEkhpNYCWCkNcKbjAwgtipRmEzAmFbGV0rIx-rnz3fr2sYfQqdoFA1WlG2j7oCLOJ3lG4oUx-vEO3bS9b-LvIpWLTEr2nzrdUca3IXiwautdrf2zokQNUash2EERpyHqqPj-6tsXNZR7_i3bCIgd8M9V8PyRn5rNV2_GyU7nQgdPe532f1UmmRTqfnmm2MXq7hdbrNQVewHaI5Yv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1685677314</pqid></control><display><type>article</type><title>Methamphetamine induces DNA damage in specific regions of the female rat brain</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Johnson, Zane ; Venters, Jace ; Guarraci, Fay A ; Zewail-Foote, Maha</creator><creatorcontrib>Johnson, Zane ; Venters, Jace ; Guarraci, Fay A ; Zewail-Foote, Maha</creatorcontrib><description>Summary
Methamphetamine (METH) is a highly addictive psychostimulant that has been shown to produce neurotoxicity. Methamphetamine increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain. In this study, we examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions. Rats treated with multiple doses of METH (10 mg/kg × 4) showed significant levels of DNA damage in the nucleus accumbens and striatum, both dopamine‐rich areas. In contrast, a single dose of METH did not lead to significant levels of DNA damage in any of the dopamine‐rich brain regions that were tested. Overall, the results of our study demonstrate that METH produces greater oxidative DNA damage in brain areas that receive greater dopamine innervation.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/1440-1681.12404</identifier><identifier>PMID: 25867833</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Animals ; Brain - drug effects ; Brain - metabolism ; comet assay ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; DNA damage ; DNA Damage - drug effects ; DNA Damage - physiology ; DNA strand breaks ; Female ; methamphetamine ; Methamphetamine - toxicity ; Nucleus Accumbens - drug effects ; Nucleus Accumbens - metabolism ; Oxidative Stress - drug effects ; Oxidative Stress - physiology ; rat brain cells ; Rats ; Rats, Long-Evans ; Reactive Oxygen Species - metabolism</subject><ispartof>Clinical and experimental pharmacology & physiology, 2015-06, Vol.42 (6), p.570-575</ispartof><rights>2015 Wiley Publishing Asia Pty Ltd</rights><rights>2015 Wiley Publishing Asia Pty Ltd.</rights><rights>Copyright © 2015 Wiley Publishing Asia Pty Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4424-178fbfb143ddeb5614fa49d009b57aa5e3d7ce43a7aae01bb2169ecc2569ed7f3</citedby><cites>FETCH-LOGICAL-c4424-178fbfb143ddeb5614fa49d009b57aa5e3d7ce43a7aae01bb2169ecc2569ed7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1440-1681.12404$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1440-1681.12404$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25867833$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Zane</creatorcontrib><creatorcontrib>Venters, Jace</creatorcontrib><creatorcontrib>Guarraci, Fay A</creatorcontrib><creatorcontrib>Zewail-Foote, Maha</creatorcontrib><title>Methamphetamine induces DNA damage in specific regions of the female rat brain</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>Summary
Methamphetamine (METH) is a highly addictive psychostimulant that has been shown to produce neurotoxicity. Methamphetamine increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain. In this study, we examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions. Rats treated with multiple doses of METH (10 mg/kg × 4) showed significant levels of DNA damage in the nucleus accumbens and striatum, both dopamine‐rich areas. In contrast, a single dose of METH did not lead to significant levels of DNA damage in any of the dopamine‐rich brain regions that were tested. Overall, the results of our study demonstrate that METH produces greater oxidative DNA damage in brain areas that receive greater dopamine innervation.</description><subject>Animals</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>comet assay</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>DNA Damage - physiology</subject><subject>DNA strand breaks</subject><subject>Female</subject><subject>methamphetamine</subject><subject>Methamphetamine - toxicity</subject><subject>Nucleus Accumbens - drug effects</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Oxidative Stress - drug effects</subject><subject>Oxidative Stress - physiology</subject><subject>rat brain cells</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1PGzEQxS1UVNLQc2-VpV56WbDX9npzTNOEIiDkwMfR8nrHxOl-BHtXhf8ebwM5cGEuMx793hvrIfSNkhMa65RyThKa5fSEppzwAzTabz6hEWFEJDSX5Ah9CWFDCBEkY5_RUSryTOaMjdDyCrq1rrdr6HTtGsCuKXsDAf9eTnGpa_0wrHDYgnHWGezhwbVNwK3F3RqwhVpXgL3ucOG1a47RodVVgK-vfYxuF_Ob2Z_k8vrsfDa9TAznKU-ozG1hC8pZWUIhMsqt5pOSkEkhpNYCWCkNcKbjAwgtipRmEzAmFbGV0rIx-rnz3fr2sYfQqdoFA1WlG2j7oCLOJ3lG4oUx-vEO3bS9b-LvIpWLTEr2nzrdUca3IXiwautdrf2zokQNUash2EERpyHqqPj-6tsXNZR7_i3bCIgd8M9V8PyRn5rNV2_GyU7nQgdPe532f1UmmRTqfnmm2MXq7hdbrNQVewHaI5Yv</recordid><startdate>201506</startdate><enddate>201506</enddate><creator>Johnson, Zane</creator><creator>Venters, Jace</creator><creator>Guarraci, Fay A</creator><creator>Zewail-Foote, Maha</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201506</creationdate><title>Methamphetamine induces DNA damage in specific regions of the female rat brain</title><author>Johnson, Zane ; Venters, Jace ; Guarraci, Fay A ; Zewail-Foote, Maha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4424-178fbfb143ddeb5614fa49d009b57aa5e3d7ce43a7aae01bb2169ecc2569ed7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>comet assay</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>DNA Damage - physiology</topic><topic>DNA strand breaks</topic><topic>Female</topic><topic>methamphetamine</topic><topic>Methamphetamine - toxicity</topic><topic>Nucleus Accumbens - drug effects</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Oxidative Stress - drug effects</topic><topic>Oxidative Stress - physiology</topic><topic>rat brain cells</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Zane</creatorcontrib><creatorcontrib>Venters, Jace</creatorcontrib><creatorcontrib>Guarraci, Fay A</creatorcontrib><creatorcontrib>Zewail-Foote, Maha</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Zane</au><au>Venters, Jace</au><au>Guarraci, Fay A</au><au>Zewail-Foote, Maha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methamphetamine induces DNA damage in specific regions of the female rat brain</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>2015-06</date><risdate>2015</risdate><volume>42</volume><issue>6</issue><spage>570</spage><epage>575</epage><pages>570-575</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>Summary
Methamphetamine (METH) is a highly addictive psychostimulant that has been shown to produce neurotoxicity. Methamphetamine increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain. In this study, we examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions. Rats treated with multiple doses of METH (10 mg/kg × 4) showed significant levels of DNA damage in the nucleus accumbens and striatum, both dopamine‐rich areas. In contrast, a single dose of METH did not lead to significant levels of DNA damage in any of the dopamine‐rich brain regions that were tested. Overall, the results of our study demonstrate that METH produces greater oxidative DNA damage in brain areas that receive greater dopamine innervation.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25867833</pmid><doi>10.1111/1440-1681.12404</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0305-1870 |
| ispartof | Clinical and experimental pharmacology & physiology, 2015-06, Vol.42 (6), p.570-575 |
| issn | 0305-1870 1440-1681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1694986014 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Brain - drug effects Brain - metabolism comet assay Corpus Striatum - drug effects Corpus Striatum - metabolism DNA damage DNA Damage - drug effects DNA Damage - physiology DNA strand breaks Female methamphetamine Methamphetamine - toxicity Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Oxidative Stress - drug effects Oxidative Stress - physiology rat brain cells Rats Rats, Long-Evans Reactive Oxygen Species - metabolism |
| title | Methamphetamine induces DNA damage in specific regions of the female rat brain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T08%3A46%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Methamphetamine%20induces%20DNA%20damage%20in%20specific%20regions%20of%20the%20female%20rat%20brain&rft.jtitle=Clinical%20and%20experimental%20pharmacology%20&%20physiology&rft.au=Johnson,%20Zane&rft.date=2015-06&rft.volume=42&rft.issue=6&rft.spage=570&rft.epage=575&rft.pages=570-575&rft.issn=0305-1870&rft.eissn=1440-1681&rft_id=info:doi/10.1111/1440-1681.12404&rft_dat=%3Cproquest_cross%3E1694986014%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1685677314&rft_id=info:pmid/25867833&rfr_iscdi=true |