IL-6, A1 and A2aR: A crosstalk that modulates BDNF and induces neuroprotection

•IL-6 is a trophic molecule for axotomized retinal ganglion cell survival in vitro.•A1 adenosine receptors mediate the effect of IL-6 on retinal ganglion cell survival.•A2a adenosine receptors mediate the effect of IL-6 on retinal ganglion cell survival.•A1R, A2aR, BDNF and IL-6 crosstalk results in...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-07, Vol.449 (4), p.477-482
Hauptverfasser:	Perígolo-Vicente, Rafael, Ritt, Karen, Gonçalves-de-Albuquerque, Cassiano Felippe, Castro-Faria-Neto, Hugo Caire, Paes-de-Carvalho, Roberto, Giestal-de-Araujo, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine receptors Animals Axotomy BDNF Brain-Derived Neurotrophic Factor - metabolism Cell culture Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Interleukin-6 - physiology Neuronal death Neuroprotective Agents - pharmacology Phenethylamines - pharmacology Rats Receptor, Adenosine A1 - biosynthesis Receptor, Adenosine A1 - physiology Receptor, Adenosine A2A - biosynthesis Receptor, Adenosine A2A - physiology Retina Retinal Ganglion Cells - pathology
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