In TFIIH, XPD Helicase Is Exclusively Devoted to DNA Repair: e1001954

The eukaryotic XPD helicase is an essential subunit of TFIIH involved in both transcription and nucleotide excision repair (NER). Mutations in human XPD are associated with several inherited diseases such as xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. We performed a comparativ...

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Veröffentlicht in:	PLoS biology 2014-09, Vol.12 (9)
Hauptverfasser:	Kuper, Jochen, Braun, Cathy, Elias, Agnes, Michels, Gudrun, Sauer, Florian, Schmitt, Dominik R, Poterszman, Arnaud, Egly, Jean-Marc, Kisker, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Chaetomium Deoxyribonucleic acid DNA DNA repair Enzymes Mutation Proteins Spectrum analysis Transcription factors
Online-Zugang:	Volltext
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