Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

•A number of biochemical perturbations in Parkinson's disease (PD) are linked to mitochondrial dysfunction.•Progress in 2014 has defined new mechanisms of PINK1 and parkin-dependent mitophagy.•α-Synuclein (α-syn) levels and aggregation link mitochondria to familial and sporadic PD.•These new in...

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Veröffentlicht in:	Trends in biochemical sciences (Amsterdam. Regular ed.) 2015-04, Vol.40 (4), p.200-210
Hauptverfasser:	Ryan, Brent J., Hoek, Selim, Fon, Edward A., Wade-Martins, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - metabolism Animals Humans Mitochondria - metabolism Mitochondria - pathology mitochondrial dysfunction mitophagy oxidative stress Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease α-synuclein
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