Coating with a novel gentamicinpalmitate formulation prevents implant-associated osteomyelitis induced by methicillin-susceptible Staphylococcus aureus in a rat model

Purpose Implant-associated osteomyelitis still represents a demanding challenge due to unfavourable biological conditions, bacterial properties and incremental resistance to antibiotic treatment. Therefore different bactericide or bacteriostatic implant coatings have been developed recently to contr...

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Veröffentlicht in:	International orthopaedics 2015-05, Vol.39 (5), p.981-988
Hauptverfasser:	Fölsch, Christian, Federmann, Maike, Kuehn, Klaus D., Kittinger, Clemens, Kogler, Stefan, Zarfel, Gernot, Kerwat, Martina, Braun, Steve, Fuchs-Winkelmann, Susanne, Paletta, Jürgen R. J., Roessler, Philip P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - therapeutic use Antibiotic Prophylaxis - methods Coated Materials, Biocompatible - administration & dosage Disease Models, Animal Gentamicins - administration & dosage Male Medicine Medicine & Public Health Original Paper Orthopedics Osteomyelitis - microbiology Osteomyelitis - prevention & control Prosthesis-Related Infections - microbiology Prosthesis-Related Infections - prevention & control Rats, Sprague-Dawley Staphylococcal Infections - prevention & control Staphylococcus aureus
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