Effect of intravenous gadolinium-DTPA on diffusion-weighted imaging of brain tumors: A short temporal interval assessment
Purpose To determine the effect of intravenous administration of gadolinium (Gd) contrast medium (Gd‐DTPA) on diffusion‐weighted imaging (DWI) for the evaluation of normal brain parenchyma vs. brain tumor following a short temporal interval. Materials and Methods Forty‐four DWI studies using b value...
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| Veröffentlicht in: | Journal of magnetic resonance imaging 2014-09, Vol.40 (3), p.616-621 |
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| creator | Li, Xiang Qu, Jin-Rong Luo, Jun-Peng Li, Jing Zhang, Hong-Kai Shao, Nan-Nan Kwok, Keith Zhang, Shou-Ning Li, Yan-le Liu, Cui-Cui Zee, Chi-Shing Li, Hai-Liang |
| description | Purpose
To determine the effect of intravenous administration of gadolinium (Gd) contrast medium (Gd‐DTPA) on diffusion‐weighted imaging (DWI) for the evaluation of normal brain parenchyma vs. brain tumor following a short temporal interval.
Materials and Methods
Forty‐four DWI studies using b values of 0 and 1000 s/mm2 were performed before, immediately after, 1 min after, 3 min after, and 5 min after the administration of Gd‐DTPA on 62 separate lesions including 15 meningioma, 17 glioma and 30 metastatic lesions. The signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR) and apparent diffusion coefficient (ADC) values of the brain tumor lesions and normal brain tissues were measured on pre‐ and postcontrast images. Statistical analysis using paired t‐test between precontrast and postcontrast data were obtained on three brain tumors and normal brain tissue.
Results
The SNR and CNR of brain tumors and the SNR of normal brain tissue showed no statistical differences between pre‐ and postcontrast (P > 0.05). The ADC values on the three cases of brain tumors demonstrated significant initial increase on the immediate time point (P < 0.01) and decrease on following the 1 min time point (P < 0.01) after contrast. Significant decrease of ADC value was still found at 3min and 5min time point in the meningioma group (P < 0.01) with gradual normalization over time. The ADC values of normal brain tissues demonstrated significant initial elevation on the immediately postcontrast DWI sequence (P < 0.01).
Conclusion
Contrast medium can cause a slight but statistically significant change on the ADC value within a short temporal interval after the contrast administration. The effect is both time and lesion‐type dependent. J. Magn. Reson. Imaging 2014;40:616–621. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmri.24386 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1694980074</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1694980074</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4996-d7a11d5452e4fa3890ec8c67b84ba9adc9d801271245c358d831cabb248296cf3</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhS0EoqVlww9AltiwSfEzsdmN-kaFVlWrLi0ndqYeEnuwnZb59zid0gUbVvdI9ztXuucA8AGjA4wQ-bIaozsgjIr6FdjFnJCKcFG_LhpxWmGBmh3wLqUVQkhKxt-CHcIk4RiLXbA57nvbZRh66HyO-sH6MCW41CYMzrtprI5urhYweGhc30_JBV89Wre8z9ZAN-ql88vZ3EbtPMzTGGL6Chcw3YeYYbbjOkQ9zLdtfChCp2RTGq3P--BNr4dk3z_PPXB7cnxzeFZdXJ6eHy4uqo5JWVem0RgbzjixrNdUSGQ70dVNK1irpTadNAJh0mDCeEe5MILiTrctYYLIuuvpHvi8vbuO4ddkU1ajS50dBu1teVXhWjIpEGrY_1HOaYMox7ygn_5BV2GKvjwyU0SUFmpaqI_P1NSO1qh1LJHFjfqbfwHwFnh0g9287DFSc7NqblY9Nau-fb8-f1LFU209LmX7-8Wj409VN7Th6u7HqTohV0fojkt1Rv8A-PKlaQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1552852263</pqid></control><display><type>article</type><title>Effect of intravenous gadolinium-DTPA on diffusion-weighted imaging of brain tumors: A short temporal interval assessment</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Li, Xiang ; Qu, Jin-Rong ; Luo, Jun-Peng ; Li, Jing ; Zhang, Hong-Kai ; Shao, Nan-Nan ; Kwok, Keith ; Zhang, Shou-Ning ; Li, Yan-le ; Liu, Cui-Cui ; Zee, Chi-Shing ; Li, Hai-Liang</creator><creatorcontrib>Li, Xiang ; Qu, Jin-Rong ; Luo, Jun-Peng ; Li, Jing ; Zhang, Hong-Kai ; Shao, Nan-Nan ; Kwok, Keith ; Zhang, Shou-Ning ; Li, Yan-le ; Liu, Cui-Cui ; Zee, Chi-Shing ; Li, Hai-Liang</creatorcontrib><description>Purpose
To determine the effect of intravenous administration of gadolinium (Gd) contrast medium (Gd‐DTPA) on diffusion‐weighted imaging (DWI) for the evaluation of normal brain parenchyma vs. brain tumor following a short temporal interval.
Materials and Methods
Forty‐four DWI studies using b values of 0 and 1000 s/mm2 were performed before, immediately after, 1 min after, 3 min after, and 5 min after the administration of Gd‐DTPA on 62 separate lesions including 15 meningioma, 17 glioma and 30 metastatic lesions. The signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR) and apparent diffusion coefficient (ADC) values of the brain tumor lesions and normal brain tissues were measured on pre‐ and postcontrast images. Statistical analysis using paired t‐test between precontrast and postcontrast data were obtained on three brain tumors and normal brain tissue.
Results
The SNR and CNR of brain tumors and the SNR of normal brain tissue showed no statistical differences between pre‐ and postcontrast (P > 0.05). The ADC values on the three cases of brain tumors demonstrated significant initial increase on the immediate time point (P < 0.01) and decrease on following the 1 min time point (P < 0.01) after contrast. Significant decrease of ADC value was still found at 3min and 5min time point in the meningioma group (P < 0.01) with gradual normalization over time. The ADC values of normal brain tissues demonstrated significant initial elevation on the immediately postcontrast DWI sequence (P < 0.01).
Conclusion
Contrast medium can cause a slight but statistically significant change on the ADC value within a short temporal interval after the contrast administration. The effect is both time and lesion‐type dependent. J. Magn. Reson. Imaging 2014;40:616–621. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1053-1807</identifier><identifier>EISSN: 1522-2586</identifier><identifier>DOI: 10.1002/jmri.24386</identifier><identifier>PMID: 24925118</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; apparent diffusion coefficients ; Brain Neoplasms - diagnosis ; brain tumor ; Contrast Media ; Diffusion Magnetic Resonance Imaging - methods ; diffusion weighted imaging ; Female ; gadolinium contrast ; Gadolinium DTPA ; Humans ; Image Interpretation, Computer-Assisted - methods ; Magnetic resonance imaging ; Male ; Middle Aged ; MRI ; Signal-To-Noise Ratio</subject><ispartof>Journal of magnetic resonance imaging, 2014-09, Vol.40 (3), p.616-621</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4996-d7a11d5452e4fa3890ec8c67b84ba9adc9d801271245c358d831cabb248296cf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmri.24386$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmri.24386$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24925118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Qu, Jin-Rong</creatorcontrib><creatorcontrib>Luo, Jun-Peng</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Zhang, Hong-Kai</creatorcontrib><creatorcontrib>Shao, Nan-Nan</creatorcontrib><creatorcontrib>Kwok, Keith</creatorcontrib><creatorcontrib>Zhang, Shou-Ning</creatorcontrib><creatorcontrib>Li, Yan-le</creatorcontrib><creatorcontrib>Liu, Cui-Cui</creatorcontrib><creatorcontrib>Zee, Chi-Shing</creatorcontrib><creatorcontrib>Li, Hai-Liang</creatorcontrib><title>Effect of intravenous gadolinium-DTPA on diffusion-weighted imaging of brain tumors: A short temporal interval assessment</title><title>Journal of magnetic resonance imaging</title><addtitle>J. Magn. Reson. Imaging</addtitle><description>Purpose
To determine the effect of intravenous administration of gadolinium (Gd) contrast medium (Gd‐DTPA) on diffusion‐weighted imaging (DWI) for the evaluation of normal brain parenchyma vs. brain tumor following a short temporal interval.
Materials and Methods
Forty‐four DWI studies using b values of 0 and 1000 s/mm2 were performed before, immediately after, 1 min after, 3 min after, and 5 min after the administration of Gd‐DTPA on 62 separate lesions including 15 meningioma, 17 glioma and 30 metastatic lesions. The signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR) and apparent diffusion coefficient (ADC) values of the brain tumor lesions and normal brain tissues were measured on pre‐ and postcontrast images. Statistical analysis using paired t‐test between precontrast and postcontrast data were obtained on three brain tumors and normal brain tissue.
Results
The SNR and CNR of brain tumors and the SNR of normal brain tissue showed no statistical differences between pre‐ and postcontrast (P > 0.05). The ADC values on the three cases of brain tumors demonstrated significant initial increase on the immediate time point (P < 0.01) and decrease on following the 1 min time point (P < 0.01) after contrast. Significant decrease of ADC value was still found at 3min and 5min time point in the meningioma group (P < 0.01) with gradual normalization over time. The ADC values of normal brain tissues demonstrated significant initial elevation on the immediately postcontrast DWI sequence (P < 0.01).
Conclusion
Contrast medium can cause a slight but statistically significant change on the ADC value within a short temporal interval after the contrast administration. The effect is both time and lesion‐type dependent. J. Magn. Reson. Imaging 2014;40:616–621. © 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>apparent diffusion coefficients</subject><subject>Brain Neoplasms - diagnosis</subject><subject>brain tumor</subject><subject>Contrast Media</subject><subject>Diffusion Magnetic Resonance Imaging - methods</subject><subject>diffusion weighted imaging</subject><subject>Female</subject><subject>gadolinium contrast</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>Signal-To-Noise Ratio</subject><issn>1053-1807</issn><issn>1522-2586</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EoqVlww9AltiwSfEzsdmN-kaFVlWrLi0ndqYeEnuwnZb59zid0gUbVvdI9ztXuucA8AGjA4wQ-bIaozsgjIr6FdjFnJCKcFG_LhpxWmGBmh3wLqUVQkhKxt-CHcIk4RiLXbA57nvbZRh66HyO-sH6MCW41CYMzrtprI5urhYweGhc30_JBV89Wre8z9ZAN-ql88vZ3EbtPMzTGGL6Chcw3YeYYbbjOkQ9zLdtfChCp2RTGq3P--BNr4dk3z_PPXB7cnxzeFZdXJ6eHy4uqo5JWVem0RgbzjixrNdUSGQ70dVNK1irpTadNAJh0mDCeEe5MILiTrctYYLIuuvpHvi8vbuO4ddkU1ajS50dBu1teVXhWjIpEGrY_1HOaYMox7ygn_5BV2GKvjwyU0SUFmpaqI_P1NSO1qh1LJHFjfqbfwHwFnh0g9287DFSc7NqblY9Nau-fb8-f1LFU209LmX7-8Wj409VN7Th6u7HqTohV0fojkt1Rv8A-PKlaQ</recordid><startdate>201409</startdate><enddate>201409</enddate><creator>Li, Xiang</creator><creator>Qu, Jin-Rong</creator><creator>Luo, Jun-Peng</creator><creator>Li, Jing</creator><creator>Zhang, Hong-Kai</creator><creator>Shao, Nan-Nan</creator><creator>Kwok, Keith</creator><creator>Zhang, Shou-Ning</creator><creator>Li, Yan-le</creator><creator>Liu, Cui-Cui</creator><creator>Zee, Chi-Shing</creator><creator>Li, Hai-Liang</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201409</creationdate><title>Effect of intravenous gadolinium-DTPA on diffusion-weighted imaging of brain tumors: A short temporal interval assessment</title><author>Li, Xiang ; Qu, Jin-Rong ; Luo, Jun-Peng ; Li, Jing ; Zhang, Hong-Kai ; Shao, Nan-Nan ; Kwok, Keith ; Zhang, Shou-Ning ; Li, Yan-le ; Liu, Cui-Cui ; Zee, Chi-Shing ; Li, Hai-Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4996-d7a11d5452e4fa3890ec8c67b84ba9adc9d801271245c358d831cabb248296cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>apparent diffusion coefficients</topic><topic>Brain Neoplasms - diagnosis</topic><topic>brain tumor</topic><topic>Contrast Media</topic><topic>Diffusion Magnetic Resonance Imaging - methods</topic><topic>diffusion weighted imaging</topic><topic>Female</topic><topic>gadolinium contrast</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>Signal-To-Noise Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Qu, Jin-Rong</creatorcontrib><creatorcontrib>Luo, Jun-Peng</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Zhang, Hong-Kai</creatorcontrib><creatorcontrib>Shao, Nan-Nan</creatorcontrib><creatorcontrib>Kwok, Keith</creatorcontrib><creatorcontrib>Zhang, Shou-Ning</creatorcontrib><creatorcontrib>Li, Yan-le</creatorcontrib><creatorcontrib>Liu, Cui-Cui</creatorcontrib><creatorcontrib>Zee, Chi-Shing</creatorcontrib><creatorcontrib>Li, Hai-Liang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of magnetic resonance imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Xiang</au><au>Qu, Jin-Rong</au><au>Luo, Jun-Peng</au><au>Li, Jing</au><au>Zhang, Hong-Kai</au><au>Shao, Nan-Nan</au><au>Kwok, Keith</au><au>Zhang, Shou-Ning</au><au>Li, Yan-le</au><au>Liu, Cui-Cui</au><au>Zee, Chi-Shing</au><au>Li, Hai-Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of intravenous gadolinium-DTPA on diffusion-weighted imaging of brain tumors: A short temporal interval assessment</atitle><jtitle>Journal of magnetic resonance imaging</jtitle><addtitle>J. Magn. Reson. Imaging</addtitle><date>2014-09</date><risdate>2014</risdate><volume>40</volume><issue>3</issue><spage>616</spage><epage>621</epage><pages>616-621</pages><issn>1053-1807</issn><eissn>1522-2586</eissn><abstract>Purpose
To determine the effect of intravenous administration of gadolinium (Gd) contrast medium (Gd‐DTPA) on diffusion‐weighted imaging (DWI) for the evaluation of normal brain parenchyma vs. brain tumor following a short temporal interval.
Materials and Methods
Forty‐four DWI studies using b values of 0 and 1000 s/mm2 were performed before, immediately after, 1 min after, 3 min after, and 5 min after the administration of Gd‐DTPA on 62 separate lesions including 15 meningioma, 17 glioma and 30 metastatic lesions. The signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR) and apparent diffusion coefficient (ADC) values of the brain tumor lesions and normal brain tissues were measured on pre‐ and postcontrast images. Statistical analysis using paired t‐test between precontrast and postcontrast data were obtained on three brain tumors and normal brain tissue.
Results
The SNR and CNR of brain tumors and the SNR of normal brain tissue showed no statistical differences between pre‐ and postcontrast (P > 0.05). The ADC values on the three cases of brain tumors demonstrated significant initial increase on the immediate time point (P < 0.01) and decrease on following the 1 min time point (P < 0.01) after contrast. Significant decrease of ADC value was still found at 3min and 5min time point in the meningioma group (P < 0.01) with gradual normalization over time. The ADC values of normal brain tissues demonstrated significant initial elevation on the immediately postcontrast DWI sequence (P < 0.01).
Conclusion
Contrast medium can cause a slight but statistically significant change on the ADC value within a short temporal interval after the contrast administration. The effect is both time and lesion‐type dependent. J. Magn. Reson. Imaging 2014;40:616–621. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24925118</pmid><doi>10.1002/jmri.24386</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over apparent diffusion coefficients Brain Neoplasms - diagnosis brain tumor Contrast Media Diffusion Magnetic Resonance Imaging - methods diffusion weighted imaging Female gadolinium contrast Gadolinium DTPA Humans Image Interpretation, Computer-Assisted - methods Magnetic resonance imaging Male Middle Aged MRI Signal-To-Noise Ratio |
| title | Effect of intravenous gadolinium-DTPA on diffusion-weighted imaging of brain tumors: A short temporal interval assessment |
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