Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates
Multidrug resistant（MDR） pathogen infections are serious threats to hospitalized patients because of the limited therapeutic options. A novel group of antibiotic candidates, antimicrobial peptides（AMPs）, have recently shown powerful activities against both Gram-negative and Gram-positive bacteria. U...
Gespeichert in:
| Veröffentlicht in: | Dōngwùxué yánjiū 2015, Vol.36 (1), p.41-47 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | chi |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 47 |
|---|---|
| container_issue | 1 |
| container_start_page | 41 |
| container_title | Dōngwùxué yánjiū |
| container_volume | 36 |
| creator | Liu, Cun-Bao Shan, Bin Bai, Hong-Mei Tang, Jing Yan, Long-Zong Ma, Yan-Bing |
| description | Multidrug resistant（MDR） pathogen infections are serious threats to hospitalized patients because of the limited therapeutic options. A novel group of antibiotic candidates, antimicrobial peptides（AMPs）, have recently shown powerful activities against both Gram-negative and Gram-positive bacteria. Unfortunately, the viability of using these AMPs in clinical settings remains to be seen, since most still need to be evaluated prior to clinical trials and not all of AMPs are potent against MDR clinical isolates. To find a connection between the characteristics of several of these AMPs and their effects against MDR pathogens, we selected 14 AMPs of animal origin with typical structures and evaluated their in vitro activities against clinical strains of extensive drugresistant Acinetobacter baumannii, methicillinresistant Staphylococcus aureus, extended spectrum β-lactamase-producing Pseudomonas aeruginosa and extended spectrum β-lactamase-producing Escherichia coli. Our results showed that these peptides＇ hydrophi |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_chong</sourceid><recordid>TN_cdi_proquest_miscellaneous_1694977856</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>663677885</cqvip_id><sourcerecordid>1694977856</sourcerecordid><originalsourceid>FETCH-LOGICAL-c606-7eab7afddaf8992198ac51b415291a31e4ca1a9f810b700f40c43ea345c3a8153</originalsourceid><addsrcrecordid>eNotkE1LxDAQhntQcF39D8GTl2LSJP04yqKusOBl72WaTLaRtOkmqbD_wR9tYD29A_PMA_PeFBtaSVHKVvK74j7Gb0p5W3GxKX73Fx38Mlpn1ct4nf1gFVEjBFAJQyTeEJiTnawKeQWOLLgkqzESjcH-oCYm-CkzdgIXc2qSRrSBoDGoUhbMZFpdPgnriQSMNqYsJMrZ2arss9E7SBgfiluTDfj4n9vi-P523O3Lw9fH5-71UKqa1mWDMDRgtAbTdl3FuhaUZINgsuoYcIZCAYPOtIwODaVGUCU4AhdScWiZ5Nvi-apdgj-vGFM_2ajQOZjRr7FndSe6pmllndGnK6pGP5_Odj71S8hvhktf17zOUK70Dy_7b3Y</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1694977856</pqid></control><display><type>article</type><title>Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates</title><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Liu, Cun-Bao ; Shan, Bin ; Bai, Hong-Mei ; Tang, Jing ; Yan, Long-Zong ; Ma, Yan-Bing</creator><creatorcontrib>Liu, Cun-Bao ; Shan, Bin ; Bai, Hong-Mei ; Tang, Jing ; Yan, Long-Zong ; Ma, Yan-Bing</creatorcontrib><description>Multidrug resistant（MDR） pathogen infections are serious threats to hospitalized patients because of the limited therapeutic options. A novel group of antibiotic candidates, antimicrobial peptides（AMPs）, have recently shown powerful activities against both Gram-negative and Gram-positive bacteria. Unfortunately, the viability of using these AMPs in clinical settings remains to be seen, since most still need to be evaluated prior to clinical trials and not all of AMPs are potent against MDR clinical isolates. To find a connection between the characteristics of several of these AMPs and their effects against MDR pathogens, we selected 14 AMPs of animal origin with typical structures and evaluated their in vitro activities against clinical strains of extensive drugresistant Acinetobacter baumannii, methicillinresistant Staphylococcus aureus, extended spectrum β-lactamase-producing Pseudomonas aeruginosa and extended spectrum β-lactamase-producing Escherichia coli. Our results showed that these peptides＇ hydrophi</description><identifier>ISSN: 0254-5853</identifier><language>chi</language><subject>Acinetobacter baumannii ; Escherichia coli ; Pseudomonas aeruginosa ; Staphylococcus aureus ; 临床试验 ; 亲水 ; 分离株 ; 动物抗菌肽 ; 多重耐药 ; 疏水性 ; 革兰氏阳性菌 ; 革兰氏阴性菌</subject><ispartof>Dōngwùxué yánjiū, 2015, Vol.36 (1), p.41-47</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/95457X/95457X.jpg</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids></links><search><creatorcontrib>Liu, Cun-Bao</creatorcontrib><creatorcontrib>Shan, Bin</creatorcontrib><creatorcontrib>Bai, Hong-Mei</creatorcontrib><creatorcontrib>Tang, Jing</creatorcontrib><creatorcontrib>Yan, Long-Zong</creatorcontrib><creatorcontrib>Ma, Yan-Bing</creatorcontrib><title>Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates</title><title>Dōngwùxué yánjiū</title><addtitle>Zoological Research</addtitle><description>Multidrug resistant（MDR） pathogen infections are serious threats to hospitalized patients because of the limited therapeutic options. A novel group of antibiotic candidates, antimicrobial peptides（AMPs）, have recently shown powerful activities against both Gram-negative and Gram-positive bacteria. Unfortunately, the viability of using these AMPs in clinical settings remains to be seen, since most still need to be evaluated prior to clinical trials and not all of AMPs are potent against MDR clinical isolates. To find a connection between the characteristics of several of these AMPs and their effects against MDR pathogens, we selected 14 AMPs of animal origin with typical structures and evaluated their in vitro activities against clinical strains of extensive drugresistant Acinetobacter baumannii, methicillinresistant Staphylococcus aureus, extended spectrum β-lactamase-producing Pseudomonas aeruginosa and extended spectrum β-lactamase-producing Escherichia coli. Our results showed that these peptides＇ hydrophi</description><subject>Acinetobacter baumannii</subject><subject>Escherichia coli</subject><subject>Pseudomonas aeruginosa</subject><subject>Staphylococcus aureus</subject><subject>临床试验</subject><subject>亲水</subject><subject>分离株</subject><subject>动物抗菌肽</subject><subject>多重耐药</subject><subject>疏水性</subject><subject>革兰氏阳性菌</subject><subject>革兰氏阴性菌</subject><issn>0254-5853</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNotkE1LxDAQhntQcF39D8GTl2LSJP04yqKusOBl72WaTLaRtOkmqbD_wR9tYD29A_PMA_PeFBtaSVHKVvK74j7Gb0p5W3GxKX73Fx38Mlpn1ct4nf1gFVEjBFAJQyTeEJiTnawKeQWOLLgkqzESjcH-oCYm-CkzdgIXc2qSRrSBoDGoUhbMZFpdPgnriQSMNqYsJMrZ2arss9E7SBgfiluTDfj4n9vi-P523O3Lw9fH5-71UKqa1mWDMDRgtAbTdl3FuhaUZINgsuoYcIZCAYPOtIwODaVGUCU4AhdScWiZ5Nvi-apdgj-vGFM_2ajQOZjRr7FndSe6pmllndGnK6pGP5_Odj71S8hvhktf17zOUK70Dy_7b3Y</recordid><startdate>2015</startdate><enddate>2015</enddate><creator>Liu, Cun-Bao</creator><creator>Shan, Bin</creator><creator>Bai, Hong-Mei</creator><creator>Tang, Jing</creator><creator>Yan, Long-Zong</creator><creator>Ma, Yan-Bing</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W94</scope><scope>WU4</scope><scope>~WA</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2015</creationdate><title>Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates</title><author>Liu, Cun-Bao ; Shan, Bin ; Bai, Hong-Mei ; Tang, Jing ; Yan, Long-Zong ; Ma, Yan-Bing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606-7eab7afddaf8992198ac51b415291a31e4ca1a9f810b700f40c43ea345c3a8153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2015</creationdate><topic>Acinetobacter baumannii</topic><topic>Escherichia coli</topic><topic>Pseudomonas aeruginosa</topic><topic>Staphylococcus aureus</topic><topic>临床试验</topic><topic>亲水</topic><topic>分离株</topic><topic>动物抗菌肽</topic><topic>多重耐药</topic><topic>疏水性</topic><topic>革兰氏阳性菌</topic><topic>革兰氏阴性菌</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Cun-Bao</creatorcontrib><creatorcontrib>Shan, Bin</creatorcontrib><creatorcontrib>Bai, Hong-Mei</creatorcontrib><creatorcontrib>Tang, Jing</creatorcontrib><creatorcontrib>Yan, Long-Zong</creatorcontrib><creatorcontrib>Ma, Yan-Bing</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-自然科学</collection><collection>中文科技期刊数据库-自然科学-生物科学</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Dōngwùxué yánjiū</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Cun-Bao</au><au>Shan, Bin</au><au>Bai, Hong-Mei</au><au>Tang, Jing</au><au>Yan, Long-Zong</au><au>Ma, Yan-Bing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates</atitle><jtitle>Dōngwùxué yánjiū</jtitle><addtitle>Zoological Research</addtitle><date>2015</date><risdate>2015</risdate><volume>36</volume><issue>1</issue><spage>41</spage><epage>47</epage><pages>41-47</pages><issn>0254-5853</issn><abstract>Multidrug resistant（MDR） pathogen infections are serious threats to hospitalized patients because of the limited therapeutic options. A novel group of antibiotic candidates, antimicrobial peptides（AMPs）, have recently shown powerful activities against both Gram-negative and Gram-positive bacteria. Unfortunately, the viability of using these AMPs in clinical settings remains to be seen, since most still need to be evaluated prior to clinical trials and not all of AMPs are potent against MDR clinical isolates. To find a connection between the characteristics of several of these AMPs and their effects against MDR pathogens, we selected 14 AMPs of animal origin with typical structures and evaluated their in vitro activities against clinical strains of extensive drugresistant Acinetobacter baumannii, methicillinresistant Staphylococcus aureus, extended spectrum β-lactamase-producing Pseudomonas aeruginosa and extended spectrum β-lactamase-producing Escherichia coli. Our results showed that these peptides＇ hydrophi</abstract><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0254-5853 |
| ispartof | Dōngwùxué yánjiū, 2015, Vol.36 (1), p.41-47 |
| issn | 0254-5853 |
| language | chi |
| recordid | cdi_proquest_miscellaneous_1694977856 |
| source | Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acinetobacter baumannii Escherichia coli Pseudomonas aeruginosa Staphylococcus aureus 临床试验 亲水 分离株 动物抗菌肽 多重耐药 疏水性 革兰氏阳性菌 革兰氏阴性菌 |
| title | Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T03%3A00%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_chong&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hydrophilic/hydrophobic%20characters%20of%20antimicrobial%20peptides%20derived%20from%20animals%20and%20their%20effects%20on%20multidrug%20resistant%20clinical%20isolates&rft.jtitle=D%C5%8Dngw%C3%B9xu%C3%A9%20y%C3%A1nji%C5%AB&rft.au=Liu,%20Cun-Bao&rft.date=2015&rft.volume=36&rft.issue=1&rft.spage=41&rft.epage=47&rft.pages=41-47&rft.issn=0254-5853&rft_id=info:doi/&rft_dat=%3Cproquest_chong%3E1694977856%3C/proquest_chong%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1694977856&rft_id=info:pmid/&rft_cqvip_id=663677885&rfr_iscdi=true |